Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy

Bibliographic Details
Main Author: Moranguinho, Inês
Publication Date: 2019
Other Authors: Borrego, Pedro, Gonçalves, Fátima, Gomes, Perpétua, Rocha, José, Barreto, Jorge, Taveira, Nuno
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.26/30476
Summary: The pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.
id RCAP_6ee7fdd3e6786fd120ef8f24dcef5e36
oai_identifier_str oai:comum.rcaap.pt:10400.26/30476
network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapyHIV-2 infected patientsGenotypic resistance profilesCape VerdeAntiretroviral therapyThe pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.Wolters KluwerRepositório ComumMoranguinho, InêsBorrego, PedroGonçalves, FátimaGomes, PerpétuaRocha, JoséBarreto, JorgeTaveira, Nuno2021-12-31T01:30:22Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30476eng0269-93701473-557110.1097/QAD.0000000000002431info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-01T16:59:16Zoai:comum.rcaap.pt:10400.26/30476Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:46:59.210688Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
spellingShingle Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
Moranguinho, Inês
HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
title_short Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_full Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_fullStr Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_full_unstemmed Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
title_sort Genotypic resistance profiles of HIV-2 infected patients from Cape Verde failing first-line antiretroviral therapy
author Moranguinho, Inês
author_facet Moranguinho, Inês
Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
author_role author
author2 Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Moranguinho, Inês
Borrego, Pedro
Gonçalves, Fátima
Gomes, Perpétua
Rocha, José
Barreto, Jorge
Taveira, Nuno
dc.subject.por.fl_str_mv HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
topic HIV-2 infected patients
Genotypic resistance profiles
Cape Verde
Antiretroviral therapy
description The pol gene from HIV-2 infected patients from Cape Verde experiencing virologic failure was sequenced and drug resistance mutations were determined. Most patients were taking a first line regimen of AZT, 3TC and LPV/r. Resistance mutations were found in most patients (11/17, 64.7%) especially I82F (4/7, 57.1%) and M184 V (10/17, 58.8%). Resistance to all reverse transcriptase and protease inhibitors was found in 58.8% (10/17) of the patients. Integrase inhibitors are warranted to treat these patients.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
2019-11-01T00:00:00Z
2021-12-31T01:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30476
url http://hdl.handle.net/10400.26/30476
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0269-9370
1473-5571
10.1097/QAD.0000000000002431
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602150651920384

Similar Items