Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors

Detalhes bibliográficos
Autor(a) principal: Dias Carvalho, Patrícia
Data de Publicação: 2019
Outros Autores: Machado, Ana Luísa, Martins, Flávia, Seruca, Raquel, VELHO, SERGIA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10400.22/15424
Resumo: Current evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cells´ aggressiveness, altering their expression profile and favoring their metastatic potential. As such, targeting the tumor microenvironment to impair cancer progression became an attractive therapeutic option. Interestingly, it has been shown that oncogenic KRAS signaling promotes a pro-tumorigenic microenvironment, and the associated crosstalk alters the expression profile of cancer cells. These findings award KRAS a key role in controlling the interactions between cancer cells and the microenvironment, granting cancer a poor prognosis. Given the lack of effective approaches to target KRAS itself or its downstream effectors in the clinic, exploring such interactions may open new perspectives on possible therapeutic strategies to hinder mutant KRAS tumors. This review highlights those communications and their implications for the development of effective therapies or to provide insights regarding response to existing regimens.
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spelling Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS TumorsTumor microenvironmentCancer therapyImmunotherapyLung cancerKRASColorectal cancerPancreatic cancerCurrent evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cells´ aggressiveness, altering their expression profile and favoring their metastatic potential. As such, targeting the tumor microenvironment to impair cancer progression became an attractive therapeutic option. Interestingly, it has been shown that oncogenic KRAS signaling promotes a pro-tumorigenic microenvironment, and the associated crosstalk alters the expression profile of cancer cells. These findings award KRAS a key role in controlling the interactions between cancer cells and the microenvironment, granting cancer a poor prognosis. Given the lack of effective approaches to target KRAS itself or its downstream effectors in the clinic, exploring such interactions may open new perspectives on possible therapeutic strategies to hinder mutant KRAS tumors. This review highlights those communications and their implications for the development of effective therapies or to provide insights regarding response to existing regimens.REPOSITÓRIO P.PORTODias Carvalho, PatríciaMachado, Ana LuísaMartins, FláviaSeruca, RaquelVELHO, SERGIA2020-02-03T15:09:12Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/15424eng10.3390/cancers11122010info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-07T10:09:37Zoai:recipp.ipp.pt:10400.22/15424Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T00:38:00.060400Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
title Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
spellingShingle Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
Dias Carvalho, Patrícia
Tumor microenvironment
Cancer therapy
Immunotherapy
Lung cancer
KRAS
Colorectal cancer
Pancreatic cancer
title_short Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
title_full Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
title_fullStr Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
title_full_unstemmed Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
title_sort Targeting the Tumor Microenvironment: An Unexplored Strategy for Mutant KRAS Tumors
author Dias Carvalho, Patrícia
author_facet Dias Carvalho, Patrícia
Machado, Ana Luísa
Martins, Flávia
Seruca, Raquel
VELHO, SERGIA
author_role author
author2 Machado, Ana Luísa
Martins, Flávia
Seruca, Raquel
VELHO, SERGIA
author2_role author
author
author
author
dc.contributor.none.fl_str_mv REPOSITÓRIO P.PORTO
dc.contributor.author.fl_str_mv Dias Carvalho, Patrícia
Machado, Ana Luísa
Martins, Flávia
Seruca, Raquel
VELHO, SERGIA
dc.subject.por.fl_str_mv Tumor microenvironment
Cancer therapy
Immunotherapy
Lung cancer
KRAS
Colorectal cancer
Pancreatic cancer
topic Tumor microenvironment
Cancer therapy
Immunotherapy
Lung cancer
KRAS
Colorectal cancer
Pancreatic cancer
description Current evidence strongly suggests that cancer cells depend on the microenvironment in order to thrive. In fact, signals from the surrounding tumor microenvironment are crucial for cancer cells´ aggressiveness, altering their expression profile and favoring their metastatic potential. As such, targeting the tumor microenvironment to impair cancer progression became an attractive therapeutic option. Interestingly, it has been shown that oncogenic KRAS signaling promotes a pro-tumorigenic microenvironment, and the associated crosstalk alters the expression profile of cancer cells. These findings award KRAS a key role in controlling the interactions between cancer cells and the microenvironment, granting cancer a poor prognosis. Given the lack of effective approaches to target KRAS itself or its downstream effectors in the clinic, exploring such interactions may open new perspectives on possible therapeutic strategies to hinder mutant KRAS tumors. This review highlights those communications and their implications for the development of effective therapies or to provide insights regarding response to existing regimens.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-02-03T15:09:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/15424
url http://hdl.handle.net/10400.22/15424
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.3390/cancers11122010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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