BREAST ANGIOSSARCOMA AFTER RADIOTHERAPY

• Main Author: Ramos, Leonor
• Publication Date: 2015
• Other Authors: Simões, Pedro, Gouveia, Miguel, Pereira, Neide, Cardoso, José Carlos, Figueiredo, Américo
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://doi.org/10.29021/spdv.72.4.335
• topic: Breast neoplasms; Hemangiosarcoma; Radiotherapy; Angiossarcoma; Neoplasias da mama; Radioterapia

Breast angiosarcoma is a rare tumor that can be divided in 3 groups: primary, secondary to chronic lymphoedema and secondary to radiotherapy (RT). It has a poor prognosis and a bad response to surgery and chemotherapy (QT). A female patient was observed with a very indurated erythematous-violaceous plaque, with an ecchymotic halo that occupied the right breast, and was evolving for 8 months. The patient had history of breast cancer, treated with surgery (tumourectomy) and local RT 5 years before. The incisional biopsy showed a vascular proliferation, arranged in nodules but also with diffuse growing, with cytological atypia and strong expression of CD31, CD34 and factor VIII, consistent with post-RT angiosarcoma. The patient begun RT and QT, but had no significant clinical response. She is now waiting for approval to begin pazopanib.