Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?

Bibliographic Details
Main Author: Qi, Zhenzhen
Publication Date: 2023
Other Authors: Yan, Zheng, Tan, Guohongfang, Jia, Tianshuo, Geng, Yiyu, Shao, Huiyan, Kundu, Subhas C, Lu, Shenzhou
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: https://hdl.handle.net/1822/85467
Summary: Microneedles are a patient-friendly technique for delivering drugs to the site of action in place of traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because of its mechanical properties, thermal stability, biocompatibility and possibility of control via genetic engineering. This review focuses on the critical research progress of silk fibroin microneedles since their inception, analyzes in detail the structure and properties of silk fibroin, the types of silk fibroin microneedles, drug delivery applications and clinical trials, and summarizes the future development trend in this field. It also proposes the future research direction of silk fibroin microneedles, including increasing drug loading doses and enriching drug loading types as well as exploring silk fibroin microneedles with stimulation-responsive drug release functions. The safety and effectiveness of silk fibroin microneedles should be further verified in clinical trials at different stages.
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spelling Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?Silk fibroin microneedlesTransdermal deliveryIntelligently responsiveClinical transformationScience & TechnologyMicroneedles are a patient-friendly technique for delivering drugs to the site of action in place of traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because of its mechanical properties, thermal stability, biocompatibility and possibility of control via genetic engineering. This review focuses on the critical research progress of silk fibroin microneedles since their inception, analyzes in detail the structure and properties of silk fibroin, the types of silk fibroin microneedles, drug delivery applications and clinical trials, and summarizes the future development trend in this field. It also proposes the future research direction of silk fibroin microneedles, including increasing drug loading doses and enriching drug loading types as well as exploring silk fibroin microneedles with stimulation-responsive drug release functions. The safety and effectiveness of silk fibroin microneedles should be further verified in clinical trials at different stages.National Natural Science Foundation of China (Grant No. 51973144), College Nature Science Research Project of Jiangsu Province, China (Grant No. 20KJA540002), PAPD and Six Talent Peaks Project in Jiangsu Province (Grant No. SWYY-038) supported this work.Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoQi, ZhenzhenYan, ZhengTan, GuohongfangJia, TianshuoGeng, YiyuShao, HuiyanKundu, Subhas CLu, Shenzhou2023-01-202023-01-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/85467engQi, Z.; Yan, Z.; Tan, G.; Jia, T.; Geng, Y.; Shao, H.; Kundu, S.C.; Lu, S. Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed? Pharmaceutics 2023, 15, 355. https://doi.org/10.3390/pharmaceutics150203551999-492310.3390/pharmaceutics15020355355https://www.mdpi.com/1999-4923/15/2/355info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-11T06:29:23Zoai:repositorium.sdum.uminho.pt:1822/85467Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T15:54:59.003496Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
title Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
spellingShingle Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
Qi, Zhenzhen
Silk fibroin microneedles
Transdermal delivery
Intelligently responsive
Clinical transformation
Science & Technology
title_short Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
title_full Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
title_fullStr Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
title_full_unstemmed Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
title_sort Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed?
author Qi, Zhenzhen
author_facet Qi, Zhenzhen
Yan, Zheng
Tan, Guohongfang
Jia, Tianshuo
Geng, Yiyu
Shao, Huiyan
Kundu, Subhas C
Lu, Shenzhou
author_role author
author2 Yan, Zheng
Tan, Guohongfang
Jia, Tianshuo
Geng, Yiyu
Shao, Huiyan
Kundu, Subhas C
Lu, Shenzhou
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Qi, Zhenzhen
Yan, Zheng
Tan, Guohongfang
Jia, Tianshuo
Geng, Yiyu
Shao, Huiyan
Kundu, Subhas C
Lu, Shenzhou
dc.subject.por.fl_str_mv Silk fibroin microneedles
Transdermal delivery
Intelligently responsive
Clinical transformation
Science & Technology
topic Silk fibroin microneedles
Transdermal delivery
Intelligently responsive
Clinical transformation
Science & Technology
description Microneedles are a patient-friendly technique for delivering drugs to the site of action in place of traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because of its mechanical properties, thermal stability, biocompatibility and possibility of control via genetic engineering. This review focuses on the critical research progress of silk fibroin microneedles since their inception, analyzes in detail the structure and properties of silk fibroin, the types of silk fibroin microneedles, drug delivery applications and clinical trials, and summarizes the future development trend in this field. It also proposes the future research direction of silk fibroin microneedles, including increasing drug loading doses and enriching drug loading types as well as exploring silk fibroin microneedles with stimulation-responsive drug release functions. The safety and effectiveness of silk fibroin microneedles should be further verified in clinical trials at different stages.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-20
2023-01-20T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/85467
url https://hdl.handle.net/1822/85467
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Qi, Z.; Yan, Z.; Tan, G.; Jia, T.; Geng, Y.; Shao, H.; Kundu, S.C.; Lu, S. Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed? Pharmaceutics 2023, 15, 355. https://doi.org/10.3390/pharmaceutics15020355
1999-4923
10.3390/pharmaceutics15020355
355
https://www.mdpi.com/1999-4923/15/2/355
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833595620177215488

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