The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi

Bibliographic Details
Main Author: Martins, Tiago M.
Publication Date: 2006
Other Authors: Domingos, Ana, Berry, Colin, Wyatt, David M.
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/145214
Summary: Funding Information: This work received financial support from the Biotechnology and Biological Sciences Research Council (DW), the British Council Treaty of Windsor Anglo-Portuguese Joint Research Programme (CB & AD) and by FCT/POCTI/FEDER, Project PROTINIB, POCTI/43637/99 (TM & AD).
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spelling The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudiAspartic proteinaseNew plasmepsinPlasmodium chabaudiRodent malaria modelParasitologyveterinary (miscalleneous)Insect ScienceInfectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: This work received financial support from the Biotechnology and Biological Sciences Research Council (DW), the British Council Treaty of Windsor Anglo-Portuguese Joint Research Programme (CB & AD) and by FCT/POCTI/FEDER, Project PROTINIB, POCTI/43637/99 (TM & AD).The rodent malaria parasite Plasmodium chabaudi encodes one food vacuole plasmepsin - the aspartic proteinases important in haemoglobin degradation. A recombinant form of this enzyme was found to cleave a variety of peptide substrates and was susceptible to a selection of naturally occurring and synthetic inhibitors, displaying an inhibition profile distinct from that of aspartic proteinases from other malaria parasites. In addition, inhibitors of HIV proteinase that kill P. chabaudi in vivo were also inhibitors of this new plasmepsin. P. chabaudi is a widely used model for human malaria species and, therefore, the characterisation of this plasmepsin is an important contribution towards understanding its biology.Centro de Malária e outras Doenças Tropicais (CMDT)RUNMartins, Tiago M.Domingos, AnaBerry, ColinWyatt, David M.2022-11-03T22:13:15Z2006-022006-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/145214eng0001-706XPURE: 46706962https://doi.org/10.1016/j.actatropica.2005.11.001info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:06:23Zoai:run.unl.pt:10362/145214Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:37:00.326446Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
title The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
spellingShingle The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
Martins, Tiago M.
Aspartic proteinase
New plasmepsin
Plasmodium chabaudi
Rodent malaria model
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
title_full The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
title_fullStr The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
title_full_unstemmed The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
title_sort The activity and inhibition of the food vacuole plasmepsin from the rodent malaria parasite Plasmodium chabaudi
author Martins, Tiago M.
author_facet Martins, Tiago M.
Domingos, Ana
Berry, Colin
Wyatt, David M.
author_role author
author2 Domingos, Ana
Berry, Colin
Wyatt, David M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Centro de Malária e outras Doenças Tropicais (CMDT)
RUN
dc.contributor.author.fl_str_mv Martins, Tiago M.
Domingos, Ana
Berry, Colin
Wyatt, David M.
dc.subject.por.fl_str_mv Aspartic proteinase
New plasmepsin
Plasmodium chabaudi
Rodent malaria model
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Aspartic proteinase
New plasmepsin
Plasmodium chabaudi
Rodent malaria model
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
SDG 3 - Good Health and Well-being
description Funding Information: This work received financial support from the Biotechnology and Biological Sciences Research Council (DW), the British Council Treaty of Windsor Anglo-Portuguese Joint Research Programme (CB & AD) and by FCT/POCTI/FEDER, Project PROTINIB, POCTI/43637/99 (TM & AD).
publishDate 2006
dc.date.none.fl_str_mv 2006-02
2006-02-01T00:00:00Z
2022-11-03T22:13:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145214
url http://hdl.handle.net/10362/145214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0001-706X
PURE: 46706962
https://doi.org/10.1016/j.actatropica.2005.11.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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