Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs

Bibliographic Details
Main Author: Torre, Carla
Publication Date: 2017
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/34769
Summary: Tese de doutoramento, Farmácia (Farmacoepidemiologia), Universidade de Lisboa, Faculdade de Farmácia, 2018
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spelling Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugsTeses de doutoramento - 2018Domínio/Área Científica::Ciências Médicas::Medicina BásicaTese de doutoramento, Farmácia (Farmacoepidemiologia), Universidade de Lisboa, Faculdade de Farmácia, 2018Chapter 1 introduces the drug life-cycle approach paradigm and emphasizes the need to get real-world data in order to meet this challenge. A systematic review to describe intensive monitoring (IM) systems’ scope in the real-world evidence generation data was presented in Chapter 2. Given that Portugal is one of the European countries with the highest uptake of the newly marketed glucose lowering drugs (GLD) (Chapter 3) monitoring drug usage and its outcomes seemed to be necessary in order to bridge knowledge at the moment of marketing approval to actual clinical practice. A pharmacy-based IM designed to track patients starting one of new GLD, was implemented and described in Chapter 4. A total of 385 pharmacies recruited an inception cohort of 1,328 subjects. At cohort entry, profile differences among incident and prevalent new users of new GLD were found. Prevalent new users, who represented almost 2/5 of study population, were more complex type 2 diabetes mellitus patients as compared with incident new users. More than two fifths reported at least one adverse drug event, most of which were experienced in the beginning of treatment. Low levels of persistence and adherence to newly GLD were observed. HRQoL results of patients starting with, or switching to new GLD, were not adversely affected; participants with worse health conditions at baseline were more likely to experience larger meaningful HRQoL improvements. In Chapter 5, the results were discussed. The implemented pharmacy-based IM model showed the importance of focused cohort studies in generating important real-life drug outcomes data in Portugal, where there is lack of use of data sources and infrastructures that permit to collect and analyse these data in a systematic manner. The method needs to be developed further but holds potential for becoming an additional tool in the Portuguese landscape of medicines’ assessment.Martins, Ana Paula, 1965-Leufkens, HubertRepositório da Universidade de LisboaTorre, Carla2018-09-06T11:17:39Z201820172018-01-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10451/34769TID:101405979enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T13:56:46Zoai:repositorio.ulisboa.pt:10451/34769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:58:49.615838Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
title Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
spellingShingle Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
Torre, Carla
Teses de doutoramento - 2018
Domínio/Área Científica::Ciências Médicas::Medicina Básica
title_short Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
title_full Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
title_fullStr Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
title_full_unstemmed Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
title_sort Intensive monitoring in Portugal : a pharmacy-based model to assess in real-life conditions : the example of new glucose lowering drugs
author Torre, Carla
author_facet Torre, Carla
author_role author
dc.contributor.none.fl_str_mv Martins, Ana Paula, 1965-
Leufkens, Hubert
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Torre, Carla
dc.subject.por.fl_str_mv Teses de doutoramento - 2018
Domínio/Área Científica::Ciências Médicas::Medicina Básica
topic Teses de doutoramento - 2018
Domínio/Área Científica::Ciências Médicas::Medicina Básica
description Tese de doutoramento, Farmácia (Farmacoepidemiologia), Universidade de Lisboa, Faculdade de Farmácia, 2018
publishDate 2017
dc.date.none.fl_str_mv 2017
2018-09-06T11:17:39Z
2018
2018-01-01T00:00:00Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/34769
TID:101405979
url http://hdl.handle.net/10451/34769
identifier_str_mv TID:101405979
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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