Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping

Bibliographic Details
Main Author: Valente Aguiar, P
Publication Date: 2022
Other Authors: Sousa, O, Silva, R, Vaz, R, Linhares, P
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.26/43496
Summary: Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.
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spelling Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotypingAstrocitomaAstrocytomaDiffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.Repositório ComumValente Aguiar, PSousa, OSilva, RVaz, RLinhares, P2023-01-31T23:06:51Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/43496eng10.1016/j.neucie.2020.09.001info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-15T10:54:09Zoai:comum.rcaap.pt:10400.26/43496Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:25:18.418732Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
title Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
spellingShingle Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
Valente Aguiar, P
Astrocitoma
Astrocytoma
title_short Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
title_full Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
title_fullStr Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
title_full_unstemmed Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
title_sort Early atypical malignant transformation of diffuse low-grade astrocytoma: The importance of genotyping
author Valente Aguiar, P
author_facet Valente Aguiar, P
Sousa, O
Silva, R
Vaz, R
Linhares, P
author_role author
author2 Sousa, O
Silva, R
Vaz, R
Linhares, P
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Valente Aguiar, P
Sousa, O
Silva, R
Vaz, R
Linhares, P
dc.subject.por.fl_str_mv Astrocitoma
Astrocytoma
topic Astrocitoma
Astrocytoma
description Diffuse astrocytoma (WHO grade II) has classically been considered a slow growing tumour, typically affecting young adults, with tendency for late malignant conversion. We describe a case of early atypical malignant transformation of diffuse astrocytoma seventeen months after complete surgical removal, as an intraventricular high-grade glioma (HGG). Retrospective laboratory findings for the presence of IDH 1/2 (isocitrate dehydrogenase) mutations were negative. There is growing evidence that IDH-wildtype (wt) astrocytomas behave more aggressively, therefore identifying IDH-mutation status should be mandatory in order to determine disease prognosis and guide treatment course.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-01-31T23:06:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/43496
url http://hdl.handle.net/10400.26/43496
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.neucie.2020.09.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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