Phage therapy: going temperate?

Detalhes bibliográficos
Autor(a) principal: Monteiro, Rodrigo
Data de Publicação: 2019
Outros Autores: Pires, Diana Priscila Penso, Costa, Ana Rita Martins, Azeredo, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/1822/59525
Resumo: Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.
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spelling Phage therapy: going temperate?Phage therapyTemperate phagesSynthetic biologyAntibiotic resistanceCRISPR-CasScience & TechnologyStrictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.This work was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project PTDC/BBB-BSS/6471/2014 (POCI-01-0145-FEDER-016678), the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684). This work was also supported by BioTecNorte operation (NORTE-01- 0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. ARC and DPP were supported by FCT grants SFRH/BPD/94648/2013 and SFRH/BPD/ 116187/2016, respectively.info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoMonteiro, RodrigoPires, Diana Priscila PensoCosta, Ana Rita MartinsAzeredo, Joana20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/59525engMonteiro, Rodrigo; Pires, Diana P.; Costa, Ana Rita; Azeredo, Joana, Phage Therapy: Going Temperate?. Trends in Microbiology, 27(4), 368-378, 2018.0966-842X10.1016/j.tim.2018.10.00830466900http://www.cell.com/trends/microbiology/homeinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-12T05:05:03Zoai:repositorium.sdum.uminho.pt:1822/59525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T16:01:56.506759Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Phage therapy: going temperate?
title Phage therapy: going temperate?
spellingShingle Phage therapy: going temperate?
Monteiro, Rodrigo
Phage therapy
Temperate phages
Synthetic biology
Antibiotic resistance
CRISPR-Cas
Science & Technology
title_short Phage therapy: going temperate?
title_full Phage therapy: going temperate?
title_fullStr Phage therapy: going temperate?
title_full_unstemmed Phage therapy: going temperate?
title_sort Phage therapy: going temperate?
author Monteiro, Rodrigo
author_facet Monteiro, Rodrigo
Pires, Diana Priscila Penso
Costa, Ana Rita Martins
Azeredo, Joana
author_role author
author2 Pires, Diana Priscila Penso
Costa, Ana Rita Martins
Azeredo, Joana
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Monteiro, Rodrigo
Pires, Diana Priscila Penso
Costa, Ana Rita Martins
Azeredo, Joana
dc.subject.por.fl_str_mv Phage therapy
Temperate phages
Synthetic biology
Antibiotic resistance
CRISPR-Cas
Science & Technology
topic Phage therapy
Temperate phages
Synthetic biology
Antibiotic resistance
CRISPR-Cas
Science & Technology
description Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction â an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/59525
url https://hdl.handle.net/1822/59525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Monteiro, Rodrigo; Pires, Diana P.; Costa, Ana Rita; Azeredo, Joana, Phage Therapy: Going Temperate?. Trends in Microbiology, 27(4), 368-378, 2018.
0966-842X
10.1016/j.tim.2018.10.008
30466900
http://www.cell.com/trends/microbiology/home
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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