The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer

Bibliographic Details
Main Author: da Silva, Inês V.
Publication Date: 2025
Other Authors: Lopes, Paula A., Fonseca, Elisabete, Vigia, Emanuel, Paulino, Jorge, Soveral, Graça
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/183107
Summary: Funding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Portugal, grant 2022.06601.PTDC, researcher contracts 2022.03691.CEECIND to I.V.d.S. and DL57/2016 to P.A.L., and strategic project UID 04138\u2014Instituto de Investiga\u00E7\u00E3o do Medicamento (iMed.ULisboa). Publisher Copyright: © 2025 by the authors.
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spelling The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic CancerA Transcriptomics Approachaquaporinsepithelial–mesenchymal transitionMAPK/ERK signaling pathwaypancreatic cancertranscriptomicsBiochemistryMolecular BiologySDG 3 - Good Health and Well-beingFunding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Portugal, grant 2022.06601.PTDC, researcher contracts 2022.03691.CEECIND to I.V.d.S. and DL57/2016 to P.A.L., and strategic project UID 04138\u2014Instituto de Investiga\u00E7\u00E3o do Medicamento (iMed.ULisboa). Publisher Copyright: © 2025 by the authors.Pancreatic cancer is one of the most lethal and challenging malignancies. Its severity is primarily linked to the constitutively activated mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. Aquaporins (AQPs) are frequently overexpressed in pancreatic cancer, playing crucial roles in cell signaling, and consequently promoting cell migration, proliferation, and invasion. Here, we investigate the transcriptomics of key players in epithelial–mesenchymal transition (EMT) and the MAPK/ERK signaling pathway in pancreatic cancer tissues, correlating them with tumor AQP expression to highlight their potential as diagnostic or prognostic tools. The transcriptomics analysis was conducted in 24 paired pancreatic tumors and adjacent healthy tissues, and analyses were performed considering the patients’ age and gender, as well as tumor invasiveness and aggressiveness. Our results revealed strong positive Pearson correlation coefficients between AQP3 and c-Jun, and between AQP5 and CDH1/EGFR in pancreatic tumors but not in healthy tissues, with posterior in vitro confirmation in pancreatic cancer BxPC3 cells, suggesting a shift in the regulatory mechanisms of gene expression that certainly affect the physiology of the tissue, influencing cancer initiation and progression. This study underscores the interplay between AQPs and cancer signaling pathways, opening new avenues for defining novel clinical biomarkers and improving the early detection of pancreatic cancer.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNda Silva, Inês V.Lopes, Paula A.Fonseca, ElisabeteVigia, EmanuelPaulino, JorgeSoveral, Graça2025-05-16T21:38:49Z2025-042025-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/183107eng2218-273XPURE: 116055962https://doi.org/10.3390/biom15040488info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:42:34Zoai:run.unl.pt:10362/183107Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:35:18.226635Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
A Transcriptomics Approach
title The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
spellingShingle The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
da Silva, Inês V.
aquaporins
epithelial–mesenchymal transition
MAPK/ERK signaling pathway
pancreatic cancer
transcriptomics
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
title_short The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
title_full The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
title_fullStr The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
title_full_unstemmed The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
title_sort The Association of Aquaporins with MAPK Signaling Pathway Unveils Potential Prognostic Biomarkers for Pancreatic Cancer
author da Silva, Inês V.
author_facet da Silva, Inês V.
Lopes, Paula A.
Fonseca, Elisabete
Vigia, Emanuel
Paulino, Jorge
Soveral, Graça
author_role author
author2 Lopes, Paula A.
Fonseca, Elisabete
Vigia, Emanuel
Paulino, Jorge
Soveral, Graça
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv da Silva, Inês V.
Lopes, Paula A.
Fonseca, Elisabete
Vigia, Emanuel
Paulino, Jorge
Soveral, Graça
dc.subject.por.fl_str_mv aquaporins
epithelial–mesenchymal transition
MAPK/ERK signaling pathway
pancreatic cancer
transcriptomics
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
topic aquaporins
epithelial–mesenchymal transition
MAPK/ERK signaling pathway
pancreatic cancer
transcriptomics
Biochemistry
Molecular Biology
SDG 3 - Good Health and Well-being
description Funding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), Portugal, grant 2022.06601.PTDC, researcher contracts 2022.03691.CEECIND to I.V.d.S. and DL57/2016 to P.A.L., and strategic project UID 04138\u2014Instituto de Investiga\u00E7\u00E3o do Medicamento (iMed.ULisboa). Publisher Copyright: © 2025 by the authors.
publishDate 2025
dc.date.none.fl_str_mv 2025-05-16T21:38:49Z
2025-04
2025-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/183107
url http://hdl.handle.net/10362/183107
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2218-273X
PURE: 116055962
https://doi.org/10.3390/biom15040488
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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