Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties

Bibliographic Details
Main Author: Marialva, Marta Sofia Pires
Publication Date: 2009
Format: Master thesis
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10451/1469
Summary: Tese de mestrado, Biologia (Biologia Evolutiva e do Desenvolvimento), 2009, Universidade de Lisboa, Faculdade de Ciências
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spelling Co-option of hedgehog and wingless pathways in the formation of evolutionary noveltiesEvoluçãoBiologia do desenvolvimentoHibridação in situTeses de mestradoTese de mestrado, Biologia (Biologia Evolutiva e do Desenvolvimento), 2009, Universidade de Lisboa, Faculdade de CiênciasResumo alargado em português disponível no documentoThe world is like a biological diversity accumulator and understanding the mechanisms responsible for the generation of this diversity is a fascinating theme in biology. The diversification of patterns and shapes can be accomplished by the origin of novelties lineage specific traits of new adaptive value. Much recent data suggest that novelties can arise from co-option: recycling of shared genetic circuitry. One of the most beautiful examples of this is found in butterfly wing patterns. Some wings have conspicuous circular paintings called eyespots development of which is divided in four main stages: prepattern, focus determination, focal signaling and cellular differentiation. There are some gaps in our knowledge about genes involved in this pattern design. Experiments with Junonia coenia revealed the expression of hedgehog around the foci in larvae, and, in Bicyclus anynana pupae, imunohistochemistry analysis showed the expression of Wingless, also a morphogen. Here, we studied the co-option of those two signaling pathways in formation of novelties using in situ hybridization to detect spatial patterns of gene expression. hedgehog was found only in the posterior area of larval wings with no higher expression around the foci as observed for J. coenia. On the other hand, it was detected that both sense and anti-sense transcripts for wingless were being expressed in eyespot foci at the same time. A model was designed to explain this finding that requires that different cells should be expressing wingless mRNA and anti-transcript. To have a better comprehension about Hedgehog and Wingless pathways involvement in eyespot formation we also analyzed expression of other genes: patched (hedgehog receptor), frizzled (wingless receptor) and groucho (a negative regulator of wingless signal transduction). However, there is still a lot to be done and the necessity of functional tests is clear.Sucena, ÉlioBeldade, PatríciaRepositório da Universidade de LisboaMarialva, Marta Sofia Pires2010-07-27T08:58:30Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdftext/xmlhttp://hdl.handle.net/10451/1469enghttp://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000572367info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-03-17T12:39:16Zoai:repositorio.ulisboa.pt:10451/1469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T02:25:00.841167Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
title Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
spellingShingle Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
Marialva, Marta Sofia Pires
Evolução
Biologia do desenvolvimento
Hibridação in situ
Teses de mestrado
title_short Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
title_full Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
title_fullStr Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
title_full_unstemmed Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
title_sort Co-option of hedgehog and wingless pathways in the formation of evolutionary novelties
author Marialva, Marta Sofia Pires
author_facet Marialva, Marta Sofia Pires
author_role author
dc.contributor.none.fl_str_mv Sucena, Élio
Beldade, Patrícia
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Marialva, Marta Sofia Pires
dc.subject.por.fl_str_mv Evolução
Biologia do desenvolvimento
Hibridação in situ
Teses de mestrado
topic Evolução
Biologia do desenvolvimento
Hibridação in situ
Teses de mestrado
description Tese de mestrado, Biologia (Biologia Evolutiva e do Desenvolvimento), 2009, Universidade de Lisboa, Faculdade de Ciências
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2010-07-27T08:58:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/1469
url http://hdl.handle.net/10451/1469
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000572367
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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repository.mail.fl_str_mv info@rcaap.pt
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