Deep into the proteomic network of Plasmodium falciparum's lipocalin

Detalhes bibliográficos
Autor(a) principal: Baptista, Vitória Cunha
Data de Publicação: 2024
Outros Autores: Rey-Souto, Cora, Silva, Miguel, Franco, Anahir, Freitas, Bruno, Catarino, Susana Oliveira, Vizoso-Vázquez, Angél, Veiga, Maria Isabel
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/1822/93682
Resumo: XXII National Congress of Biochemistry, Aveiro, Portugal, 24-26 October 2024
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spelling Deep into the proteomic network of Plasmodium falciparum's lipocalinEngenharia e Tecnologia::Engenharia MédicaSaúde de qualidadeXXII National Congress of Biochemistry, Aveiro, Portugal, 24-26 October 2024Malaria, an infectious disease caused by Plasmodium parasites, threats half of the world's population yearly due to the parasite's ability to develop resistance to antimalarial drugs. Therefore, innovative intervention strategies, which rely on a deeper understanding of the parasite's complex biology are urgently needed. Most antimalarial drugs target the symptomatic stage of infection of the parasite that is the one responsible for the symptoms of the disease. During this stage, the parasite ingests hemoglobin into an acidic digestive vacuole. Hemoglobin degradation releases toxic free heme that is converted into hemozoin. While hemozoin formation process is unclear, it is unique and vital for the parasite. Recently, a lipocalin protein was identified in Plasmodium falciparum and its conditional knockout demonstrated to cause malformations in hemozoin formation and consequent parasite death. Thus, given the somewhat role of lipocalin in hemozoin formation, we sought to study its interacting partners to identify the key players in this process. To accomplish this, we based our research on the yeast two-hybrid system with lipocalin as bait and performed mass spectrometry on gene-edited parasite lines overexpressing lipocalin. This research will deepen our understanding of hemozoin formation and potentially uncover new targets for developing new malaria therapies.Vitória Baptista thanks the European Molecular Biology Organization (EMBO) for an EMBO Scientific Exchange Grant and the Federation of European Microbiology Societies (FEMS) for a FEMS Research and Training Grant for the funding.Universidade do MinhoBaptista, Vitória CunhaRey-Souto, CoraSilva, MiguelFranco, AnahirFreitas, BrunoCatarino, Susana OliveiraVizoso-Vázquez, AngélVeiga, Maria Isabel2024-10-262024-10-26T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/93682enginfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-23T01:18:23Zoai:repositorium.sdum.uminho.pt:1822/93682Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:15:37.636923Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Deep into the proteomic network of Plasmodium falciparum's lipocalin
title Deep into the proteomic network of Plasmodium falciparum's lipocalin
spellingShingle Deep into the proteomic network of Plasmodium falciparum's lipocalin
Baptista, Vitória Cunha
Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
title_short Deep into the proteomic network of Plasmodium falciparum's lipocalin
title_full Deep into the proteomic network of Plasmodium falciparum's lipocalin
title_fullStr Deep into the proteomic network of Plasmodium falciparum's lipocalin
title_full_unstemmed Deep into the proteomic network of Plasmodium falciparum's lipocalin
title_sort Deep into the proteomic network of Plasmodium falciparum's lipocalin
author Baptista, Vitória Cunha
author_facet Baptista, Vitória Cunha
Rey-Souto, Cora
Silva, Miguel
Franco, Anahir
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
author_role author
author2 Rey-Souto, Cora
Silva, Miguel
Franco, Anahir
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Baptista, Vitória Cunha
Rey-Souto, Cora
Silva, Miguel
Franco, Anahir
Freitas, Bruno
Catarino, Susana Oliveira
Vizoso-Vázquez, Angél
Veiga, Maria Isabel
dc.subject.por.fl_str_mv Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
topic Engenharia e Tecnologia::Engenharia Médica
Saúde de qualidade
description XXII National Congress of Biochemistry, Aveiro, Portugal, 24-26 October 2024
publishDate 2024
dc.date.none.fl_str_mv 2024-10-26
2024-10-26T00:00:00Z
dc.type.driver.fl_str_mv conference object
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/93682
url https://hdl.handle.net/1822/93682
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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