Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon
| Main Author: | |
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| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/175539 |
Summary: | Funding agency: International Center of Excellence in Malaria Research (ICEMR). US Public Health Service, National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID), USA (U19AI089681). Fogarty Training Grant (NIH-USA) (2D43TW007120-11A). |
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Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian AmazonPublic Health, Environmental and Occupational HealthInfectious DiseasesSDG 3 - Good Health and Well-beingFunding agency: International Center of Excellence in Malaria Research (ICEMR). US Public Health Service, National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID), USA (U19AI089681). Fogarty Training Grant (NIH-USA) (2D43TW007120-11A).BACKGROUND: In the Peruvian Amazon, Plasmodium vivax malaria transmission is maintained due to the high frequency of recurrences. By understanding the recurrence rates of submicroscopic and asymptomatic cases, we can develop informed strategies to prevent transmission more efficiently and disrupt the silent transmission cycle. METHODS: A three-year, population-based cohort study was conducted in two sites, Cahuide and Lupuna, within the Loreto region in Peru from 2013 to 2015. The study included 385 individuals and aimed to examine the temporal dynamics of malaria recurrences and their impact on transmission and control. RESULTS: Individuals from Lupuna presented a higher risk of P. vivax infections compared to Cahuide, where most recurrences were asymptomatic and submicroscopic. It is estimated that a great proportion of these recurrences were due to relapses in both communities. The application of molecular diagnostic method proved to be significantly more effective, detecting 2.3 times more episodes during the follow-up (PCR, 1068; microscopy, 467). PCR identified recurrences significantly earlier, at 151 days after an initial infection, compared to microscopy, which detected them on average after 365 days. Community, occupation and previous malaria infections were factors associated with recurrences. Finally, potential infection evolution scenarios were described where one frequent scenario involved the transition from symptomatic to asymptomatic infections with a mean evolution time of 240 days. CONCLUSIONS: This study explores the contrast in malaria recurrence risk among individuals from two endemic settings, a consequence of prolonged exposure to the parasite. Through the analysis of the evolution scenarios of P. vivax recurrences, it is possible to have a more complete vision of how the transmission pattern changes over time and is conditioned by different factors.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Individual Health Care (IHC)RUNGarcia Castillo, Stefano S.Abanto Alvarez, CarolineRosas-Aguirre, ÁngelAcosta, CarlosCorder, Rodrigo M.Gómez, JoaquínGuzmán, MitchelSpeybroeck, NikoLlanos-Cuentas, AlejandroCastro, Marcia C.Rosanas-Urgell, AnnaFerreira, Marcelo U.Vinetz, Joseph M.Gamboa, DioniciaTorres, Katherine2024-11-20T00:54:26Z2024-10-012024-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/175539eng1935-2727PURE: 103436663https://doi.org/10.1371/journal.pntd.0012566info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-25T01:37:45Zoai:run.unl.pt:10362/175539Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:15:53.486365Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| title |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| spellingShingle |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon Garcia Castillo, Stefano S. Public Health, Environmental and Occupational Health Infectious Diseases SDG 3 - Good Health and Well-being |
| title_short |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| title_full |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| title_fullStr |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| title_full_unstemmed |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| title_sort |
Recurrence patterns and evolution of submicroscopic and asymptomatic Plasmodium vivax infections in malaria-endemic areas of the Peruvian Amazon |
| author |
Garcia Castillo, Stefano S. |
| author_facet |
Garcia Castillo, Stefano S. Abanto Alvarez, Caroline Rosas-Aguirre, Ángel Acosta, Carlos Corder, Rodrigo M. Gómez, Joaquín Guzmán, Mitchel Speybroeck, Niko Llanos-Cuentas, Alejandro Castro, Marcia C. Rosanas-Urgell, Anna Ferreira, Marcelo U. Vinetz, Joseph M. Gamboa, Dionicia Torres, Katherine |
| author_role |
author |
| author2 |
Abanto Alvarez, Caroline Rosas-Aguirre, Ángel Acosta, Carlos Corder, Rodrigo M. Gómez, Joaquín Guzmán, Mitchel Speybroeck, Niko Llanos-Cuentas, Alejandro Castro, Marcia C. Rosanas-Urgell, Anna Ferreira, Marcelo U. Vinetz, Joseph M. Gamboa, Dionicia Torres, Katherine |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Individual Health Care (IHC) RUN |
| dc.contributor.author.fl_str_mv |
Garcia Castillo, Stefano S. Abanto Alvarez, Caroline Rosas-Aguirre, Ángel Acosta, Carlos Corder, Rodrigo M. Gómez, Joaquín Guzmán, Mitchel Speybroeck, Niko Llanos-Cuentas, Alejandro Castro, Marcia C. Rosanas-Urgell, Anna Ferreira, Marcelo U. Vinetz, Joseph M. Gamboa, Dionicia Torres, Katherine |
| dc.subject.por.fl_str_mv |
Public Health, Environmental and Occupational Health Infectious Diseases SDG 3 - Good Health and Well-being |
| topic |
Public Health, Environmental and Occupational Health Infectious Diseases SDG 3 - Good Health and Well-being |
| description |
Funding agency: International Center of Excellence in Malaria Research (ICEMR). US Public Health Service, National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID), USA (U19AI089681). Fogarty Training Grant (NIH-USA) (2D43TW007120-11A). |
| publishDate |
2024 |
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2024-11-20T00:54:26Z 2024-10-01 2024-10-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10362/175539 |
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http://hdl.handle.net/10362/175539 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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1935-2727 PURE: 103436663 https://doi.org/10.1371/journal.pntd.0012566 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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