A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity

Bibliographic Details
Main Author: Ferreira, Daniela Alves
Publication Date: 2020
Other Authors: Martins, Luísa Margarida Dias Ribeiro de Sousa, Fernandes, Alexandra R., Martins, Marta
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/114147
Summary: Postgraduate Research (1252) Studentship UIDB/04378/2020
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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spelling A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activityAntimicrobial resistanceDrug repurposingMetallic compoundsMicrobiologyBiochemistryPharmacology, Toxicology and Pharmaceutics(all)Microbiology (medical)Infectious DiseasesPharmacology (medical)SDG 3 - Good Health and Well-beingPostgraduate Research (1252) Studentship UIDB/04378/2020The rise in antibiotic resistance coupled with the gap in the discovery of active molecules has driven the need for more effective antimicrobials while focusing the attention into the repurpose of already existing drugs. Here, we evaluated the potential antibacterial activity of one cobalt and two zinc metallic compounds previously reported as having anticancer properties. Compounds were tested against a range of Gram‐positive and ‐negative bacteria. The determination of the minimum inhibitory and bactericidal concentrations (MIC/MBC) of the drugs were used to assess their potential antibacterial activity and their effect on bacterial growth. Motility assays were conducted by exposing the bacteria to sub‐MIC of each of the compounds. The effect of sub‐MIC of the compounds on the membrane permeability was measured by ethidium bromide (EtBr) accumulation assay. Cell viability assays were performed in human cells. Compound TS262 was the most active against the range of bacteria tested. No effect was observed on the motility or accumulation of EtBr for any of the bacteria tested. Cell viability assays demonstrated that the compounds showed a decrease in cell viability at the MIC. These results are promising, and further studies on these compounds can lead to the development of new effective antimicrobials.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaRUNFerreira, Daniela AlvesMartins, Luísa Margarida Dias Ribeiro de SousaFernandes, Alexandra R.Martins, Marta2021-03-19T23:28:45Z2020-06-112020-06-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/114147eng2079-6382PURE: 28446544https://doi.org/10.3390/antibiotics9060321info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:51:16Zoai:run.unl.pt:10362/114147Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:22:30.388047Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
title A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
spellingShingle A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
Ferreira, Daniela Alves
Antimicrobial resistance
Drug repurposing
Metallic compounds
Microbiology
Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
title_short A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
title_full A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
title_fullStr A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
title_full_unstemmed A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
title_sort A tale of two ends: Repurposing metallic compounds from anti‐tumour agents to effective antibacterial activity
author Ferreira, Daniela Alves
author_facet Ferreira, Daniela Alves
Martins, Luísa Margarida Dias Ribeiro de Sousa
Fernandes, Alexandra R.
Martins, Marta
author_role author
author2 Martins, Luísa Margarida Dias Ribeiro de Sousa
Fernandes, Alexandra R.
Martins, Marta
author2_role author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
RUN
dc.contributor.author.fl_str_mv Ferreira, Daniela Alves
Martins, Luísa Margarida Dias Ribeiro de Sousa
Fernandes, Alexandra R.
Martins, Marta
dc.subject.por.fl_str_mv Antimicrobial resistance
Drug repurposing
Metallic compounds
Microbiology
Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
topic Antimicrobial resistance
Drug repurposing
Metallic compounds
Microbiology
Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)
SDG 3 - Good Health and Well-being
description Postgraduate Research (1252) Studentship UIDB/04378/2020
publishDate 2020
dc.date.none.fl_str_mv 2020-06-11
2020-06-11T00:00:00Z
2021-03-19T23:28:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114147
url http://hdl.handle.net/10362/114147
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2079-6382
PURE: 28446544
https://doi.org/10.3390/antibiotics9060321
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596647818395648

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