HBM4EU E-waste study

Detalhes bibliográficos
Autor(a) principal: HBM4EU E-waste Study Team
Data de Publicação: 2025
Outros Autores: Kozlowska, Lucyna, Viegas, Susana, Scheepers, Paul T.J., Duca, Radu C., Godderis, Lode, Martins, Carla, Ciura, Krzesimir, Jagiello, Karolina, Silva, Maria João, Mahiout, Selma, Martinsone, Inese, Matisane, Linda, van Nieuwenhuyse, An, Puzyn, Tomasz, Sijko-Szpanska, Monika, Verdonck, Jelle, Santonen, Tiina, Aimonen, Kukka, Akulova, Lasma, Bousoumah, Radia, Castaño, Argelia, Clarke, Adam, Covaci, Adrian, van Dael, Maurice, López, Marta Esteban, Göeno, Thomas, Graumans, Martien, Hanser, Ogier, Janasik, Beata, Jones, Kate, Komarovska, Laura, Laitinen, Sirpa, Louro, Henriqueta, Moreira, Rodrigo, Musgrove, Darren, Ani, Maria Mirela, Toda, Maria Torres, Nogueira, Ana, Paegle, Linda, Pinhal, Hermínia, Rantio, Tiina, Santos, Sílvia Reis, Ribeiro, Edna, Róg, Joanna, Seile, Anita, Silva, Marina, Vänskä, Marjo, Ventura, Célia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: http://hdl.handle.net/10362/183188
Resumo: Funding Information: HBM4EU E-Waste Study Team: The HBM4EU e-waste study team consists of Kukka Aimonen l, Lasma Akulova m, Radia Bousoumah n, Argelia Casta\u00F1o o, Adam Clarke p, Adrian Covaci q, Maurice van Dael c, Marta Esteban L\u00F3pez o, Thomas G\u00F6eno c, Martien Graumans c, Ogier Hanser n, Beata Janasik r, Kate Jones p, Laura Komarovska m, Sirpa Laitinen l, Henriqueta Louro s, Carla Martins b, Linda Matisane m, Inese Martinsone m, Rodrigo Moreira u, Darren Musgrove p, Maria-Mirela Ani d, Maria Torres Toda f, Ana Nogueira s, Linda Paegle m, Herm\u00EDnia Pinhal s, Tiina Rantio l, S\u00EDlvia Reis Santos s, Edna Ribeiro t, Joanna R\u00F3g a, Anita Seile m, Marina Silva t, S\u00EDlvia Reis Santos s, Marjo V\u00E4nsk\u00E4 l, Riitta Velin l, C\u00E9lia Ventura j,u and Wojciech Wasowicz r., Affiliations of these authors can be found in Supplementary material S3. Funding Information: This work has received external funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author\u2019s organizations and/or Ministries. In addition, the Finnish Work Environment fund provided funding (grant no. 200345). The publication was financed by the Science Development Fund of the Warsaw University of Life Sciences \u2013 SGGW. Publisher Copyright: © 2025 The Author(s)
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spelling HBM4EU E-waste studyan untargeted metabolomics approach to characterize metabolic changes during E-waste recyclingBiomarkersMixture exposureOccupational exposureRecyclingUrine metabolomicsEnvironmental Science(all)SDG 3 - Good Health and Well-beingSDG 12 - Responsible Consumption and ProductionFunding Information: HBM4EU E-Waste Study Team: The HBM4EU e-waste study team consists of Kukka Aimonen l, Lasma Akulova m, Radia Bousoumah n, Argelia Casta\u00F1o o, Adam Clarke p, Adrian Covaci q, Maurice van Dael c, Marta Esteban L\u00F3pez o, Thomas G\u00F6eno c, Martien Graumans c, Ogier Hanser n, Beata Janasik r, Kate Jones p, Laura Komarovska m, Sirpa Laitinen l, Henriqueta Louro s, Carla Martins b, Linda Matisane m, Inese Martinsone m, Rodrigo Moreira u, Darren Musgrove p, Maria-Mirela Ani d, Maria Torres Toda f, Ana Nogueira s, Linda Paegle m, Herm\u00EDnia Pinhal s, Tiina Rantio l, S\u00EDlvia Reis Santos s, Edna Ribeiro t, Joanna R\u00F3g a, Anita Seile m, Marina Silva t, S\u00EDlvia Reis Santos s, Marjo V\u00E4nsk\u00E4 l, Riitta Velin l, C\u00E9lia Ventura j,u and Wojciech Wasowicz r., Affiliations of these authors can be found in Supplementary material S3. Funding Information: This work has received external funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author\u2019s organizations and/or Ministries. In addition, the Finnish Work Environment fund provided funding (grant no. 200345). The publication was financed by the Science Development Fund of the Warsaw University of Life Sciences \u2013 SGGW. Publisher Copyright: © 2025 The Author(s)E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine samples were obtained from workers involved in the processing of e-waste (sorting, dismantling, shredding, pre-processing, metal, and non-metal processing), as well as from controls with no known occupational exposure. Pre- and post-shift urine samples were collected and analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total of 32 endogenous urinary metabolites were annotated with a Variable Importance in Projection (VIP) above 2, indicating that e-waste recycling is mainly associated with changes in steroid hormone and neurotransmitter metabolism, energy metabolism, bile acid biosynthesis, and inflammation. The highest VIP was observed for dopamine-o-quinone, which is linked to Parkinson's disease. These and other changes in metabolism in workers employed in the processing of e-waste need further verification in targeted studies.Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo ENSP)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNHBM4EU E-waste Study TeamKozlowska, LucynaViegas, SusanaScheepers, Paul T.J.Duca, Radu C.Godderis, LodeMartins, CarlaCiura, KrzesimirJagiello, KarolinaSilva, Maria JoãoMahiout, SelmaMartinsone, IneseMatisane, Lindavan Nieuwenhuyse, AnPuzyn, TomaszSijko-Szpanska, MonikaVerdonck, JelleSantonen, TiinaAimonen, KukkaAkulova, LasmaBousoumah, RadiaCastaño, ArgeliaClarke, AdamCovaci, Adrianvan Dael, MauriceLópez, Marta EstebanGöeno, ThomasGraumans, MartienHanser, OgierJanasik, BeataJones, KateKomarovska, LauraLaitinen, SirpaLouro, HenriquetaMatisane, LindaMartinsone, IneseMoreira, RodrigoMusgrove, DarrenAni, Maria MirelaToda, Maria TorresNogueira, AnaPaegle, LindaPinhal, HermíniaRantio, TiinaSantos, Sílvia ReisRibeiro, EdnaRóg, JoannaSeile, AnitaSilva, MarinaVänskä, MarjoVentura, Célia2025-05-19T21:18:18Z2025-022025-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/183188eng0160-4120PURE: 116382909https://doi.org/10.1016/j.envint.2025.109281info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:42:36Zoai:run.unl.pt:10362/183188Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T07:36:38.237618Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv HBM4EU E-waste study
an untargeted metabolomics approach to characterize metabolic changes during E-waste recycling
title HBM4EU E-waste study
spellingShingle HBM4EU E-waste study
HBM4EU E-waste Study Team
Biomarkers
Mixture exposure
Occupational exposure
Recycling
Urine metabolomics
Environmental Science(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
title_short HBM4EU E-waste study
title_full HBM4EU E-waste study
title_fullStr HBM4EU E-waste study
title_full_unstemmed HBM4EU E-waste study
title_sort HBM4EU E-waste study
author HBM4EU E-waste Study Team
author_facet HBM4EU E-waste Study Team
Kozlowska, Lucyna
Viegas, Susana
Scheepers, Paul T.J.
Duca, Radu C.
Godderis, Lode
Martins, Carla
Ciura, Krzesimir
Jagiello, Karolina
Silva, Maria João
Mahiout, Selma
Martinsone, Inese
Matisane, Linda
van Nieuwenhuyse, An
Puzyn, Tomasz
Sijko-Szpanska, Monika
Verdonck, Jelle
Santonen, Tiina
Aimonen, Kukka
Akulova, Lasma
Bousoumah, Radia
Castaño, Argelia
Clarke, Adam
Covaci, Adrian
van Dael, Maurice
López, Marta Esteban
Göeno, Thomas
Graumans, Martien
Hanser, Ogier
Janasik, Beata
Jones, Kate
Komarovska, Laura
Laitinen, Sirpa
Louro, Henriqueta
Moreira, Rodrigo
Musgrove, Darren
Ani, Maria Mirela
Toda, Maria Torres
Nogueira, Ana
Paegle, Linda
Pinhal, Hermínia
Rantio, Tiina
Santos, Sílvia Reis
Ribeiro, Edna
Róg, Joanna
Seile, Anita
Silva, Marina
Vänskä, Marjo
Ventura, Célia
author_role author
author2 Kozlowska, Lucyna
Viegas, Susana
Scheepers, Paul T.J.
Duca, Radu C.
Godderis, Lode
Martins, Carla
Ciura, Krzesimir
Jagiello, Karolina
Silva, Maria João
Mahiout, Selma
Martinsone, Inese
Matisane, Linda
van Nieuwenhuyse, An
Puzyn, Tomasz
Sijko-Szpanska, Monika
Verdonck, Jelle
Santonen, Tiina
Aimonen, Kukka
Akulova, Lasma
Bousoumah, Radia
Castaño, Argelia
Clarke, Adam
Covaci, Adrian
van Dael, Maurice
López, Marta Esteban
Göeno, Thomas
Graumans, Martien
Hanser, Ogier
Janasik, Beata
Jones, Kate
Komarovska, Laura
Laitinen, Sirpa
Louro, Henriqueta
Moreira, Rodrigo
Musgrove, Darren
Ani, Maria Mirela
Toda, Maria Torres
Nogueira, Ana
Paegle, Linda
Pinhal, Hermínia
Rantio, Tiina
Santos, Sílvia Reis
Ribeiro, Edna
Róg, Joanna
Seile, Anita
Silva, Marina
Vänskä, Marjo
Ventura, Célia
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dc.contributor.none.fl_str_mv Laboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo ENSP)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
Escola Nacional de Saúde Pública (ENSP)
Centro de Investigação em Saúde Pública (CISP/PHRC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv HBM4EU E-waste Study Team
Kozlowska, Lucyna
Viegas, Susana
Scheepers, Paul T.J.
Duca, Radu C.
Godderis, Lode
Martins, Carla
Ciura, Krzesimir
Jagiello, Karolina
Silva, Maria João
Mahiout, Selma
Martinsone, Inese
Matisane, Linda
van Nieuwenhuyse, An
Puzyn, Tomasz
Sijko-Szpanska, Monika
Verdonck, Jelle
Santonen, Tiina
Aimonen, Kukka
Akulova, Lasma
Bousoumah, Radia
Castaño, Argelia
Clarke, Adam
Covaci, Adrian
van Dael, Maurice
López, Marta Esteban
Göeno, Thomas
Graumans, Martien
Hanser, Ogier
Janasik, Beata
Jones, Kate
Komarovska, Laura
Laitinen, Sirpa
Louro, Henriqueta
Matisane, Linda
Martinsone, Inese
Moreira, Rodrigo
Musgrove, Darren
Ani, Maria Mirela
Toda, Maria Torres
Nogueira, Ana
Paegle, Linda
Pinhal, Hermínia
Rantio, Tiina
Santos, Sílvia Reis
Ribeiro, Edna
Róg, Joanna
Seile, Anita
Silva, Marina
Vänskä, Marjo
Ventura, Célia
dc.subject.por.fl_str_mv Biomarkers
Mixture exposure
Occupational exposure
Recycling
Urine metabolomics
Environmental Science(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
topic Biomarkers
Mixture exposure
Occupational exposure
Recycling
Urine metabolomics
Environmental Science(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
description Funding Information: HBM4EU E-Waste Study Team: The HBM4EU e-waste study team consists of Kukka Aimonen l, Lasma Akulova m, Radia Bousoumah n, Argelia Casta\u00F1o o, Adam Clarke p, Adrian Covaci q, Maurice van Dael c, Marta Esteban L\u00F3pez o, Thomas G\u00F6eno c, Martien Graumans c, Ogier Hanser n, Beata Janasik r, Kate Jones p, Laura Komarovska m, Sirpa Laitinen l, Henriqueta Louro s, Carla Martins b, Linda Matisane m, Inese Martinsone m, Rodrigo Moreira u, Darren Musgrove p, Maria-Mirela Ani d, Maria Torres Toda f, Ana Nogueira s, Linda Paegle m, Herm\u00EDnia Pinhal s, Tiina Rantio l, S\u00EDlvia Reis Santos s, Edna Ribeiro t, Joanna R\u00F3g a, Anita Seile m, Marina Silva t, S\u00EDlvia Reis Santos s, Marjo V\u00E4nsk\u00E4 l, Riitta Velin l, C\u00E9lia Ventura j,u and Wojciech Wasowicz r., Affiliations of these authors can be found in Supplementary material S3. Funding Information: This work has received external funding from the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author\u2019s organizations and/or Ministries. In addition, the Finnish Work Environment fund provided funding (grant no. 200345). The publication was financed by the Science Development Fund of the Warsaw University of Life Sciences \u2013 SGGW. Publisher Copyright: © 2025 The Author(s)
publishDate 2025
dc.date.none.fl_str_mv 2025-05-19T21:18:18Z
2025-02
2025-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/183188
url http://hdl.handle.net/10362/183188
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0160-4120
PURE: 116382909
https://doi.org/10.1016/j.envint.2025.109281
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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