An overview of the role of long non-coding RNAs in human choriocarcinoma

Bibliographic Details
Main Author: Di Fiore, Riccardo
Publication Date: 2021
Other Authors: Suleiman, Sherif, Felix, Ana, O’toole, Sharon A., O’leary, John J., Ward, Mark P., Beirne, James, Sabol, Maja, Ozretić, Petar, Yordanov, Angel, Vasileva-Slaveva, Mariela, Kostov, Stoyan, Nikolova, Margarita, Said-Huntingford, Ian, Ayers, Duncan, Ellul, Bridget, Pentimalli, Francesca, Giordano, Antonio, Calleja-Agius, Jean
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/120547
Summary: Funding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action.
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spelling An overview of the role of long non-coding RNAs in human choriocarcinomaChoriocarcinomaLncRNA-based therapyLong non-coding RNAOncogenes or tumor suppressor genesRare cancerCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action.Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDi Fiore, RiccardoSuleiman, SherifFelix, AnaO’toole, Sharon A.O’leary, John J.Ward, Mark P.Beirne, JamesSabol, MajaOzretić, PetarYordanov, AngelVasileva-Slaveva, MarielaKostov, StoyanNikolova, MargaritaSaid-Huntingford, IanAyers, DuncanEllul, BridgetPentimalli, FrancescaGiordano, AntonioCalleja-Agius, Jean2021-07-05T22:18:22Z2021-06-022021-06-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/120547eng1661-6596PURE: 32161602https://doi.org/10.3390/ijms22126506info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:54:25Zoai:run.unl.pt:10362/120547Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:25:20.647932Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv An overview of the role of long non-coding RNAs in human choriocarcinoma
title An overview of the role of long non-coding RNAs in human choriocarcinoma
spellingShingle An overview of the role of long non-coding RNAs in human choriocarcinoma
Di Fiore, Riccardo
Choriocarcinoma
LncRNA-based therapy
Long non-coding RNA
Oncogenes or tumor suppressor genes
Rare cancer
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short An overview of the role of long non-coding RNAs in human choriocarcinoma
title_full An overview of the role of long non-coding RNAs in human choriocarcinoma
title_fullStr An overview of the role of long non-coding RNAs in human choriocarcinoma
title_full_unstemmed An overview of the role of long non-coding RNAs in human choriocarcinoma
title_sort An overview of the role of long non-coding RNAs in human choriocarcinoma
author Di Fiore, Riccardo
author_facet Di Fiore, Riccardo
Suleiman, Sherif
Felix, Ana
O’toole, Sharon A.
O’leary, John J.
Ward, Mark P.
Beirne, James
Sabol, Maja
Ozretić, Petar
Yordanov, Angel
Vasileva-Slaveva, Mariela
Kostov, Stoyan
Nikolova, Margarita
Said-Huntingford, Ian
Ayers, Duncan
Ellul, Bridget
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
author_role author
author2 Suleiman, Sherif
Felix, Ana
O’toole, Sharon A.
O’leary, John J.
Ward, Mark P.
Beirne, James
Sabol, Maja
Ozretić, Petar
Yordanov, Angel
Vasileva-Slaveva, Mariela
Kostov, Stoyan
Nikolova, Margarita
Said-Huntingford, Ian
Ayers, Duncan
Ellul, Bridget
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Di Fiore, Riccardo
Suleiman, Sherif
Felix, Ana
O’toole, Sharon A.
O’leary, John J.
Ward, Mark P.
Beirne, James
Sabol, Maja
Ozretić, Petar
Yordanov, Angel
Vasileva-Slaveva, Mariela
Kostov, Stoyan
Nikolova, Margarita
Said-Huntingford, Ian
Ayers, Duncan
Ellul, Bridget
Pentimalli, Francesca
Giordano, Antonio
Calleja-Agius, Jean
dc.subject.por.fl_str_mv Choriocarcinoma
LncRNA-based therapy
Long non-coding RNA
Oncogenes or tumor suppressor genes
Rare cancer
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic Choriocarcinoma
LncRNA-based therapy
Long non-coding RNA
Oncogenes or tumor suppressor genes
Rare cancer
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-05T22:18:22Z
2021-06-02
2021-06-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120547
url http://hdl.handle.net/10362/120547
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 32161602
https://doi.org/10.3390/ijms22126506
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
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collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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