An overview of the role of long non-coding RNAs in human choriocarcinoma
| Main Author: | |
|---|---|
| Publication Date: | 2021 |
| Other Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Other |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/120547 |
Summary: | Funding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action. |
| id |
RCAP_469ce8bcaadca83654adb5a6c2ef6dc1 |
|---|---|
| oai_identifier_str |
oai:run.unl.pt:10362/120547 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository_id_str |
https://opendoar.ac.uk/repository/7160 |
| spelling |
An overview of the role of long non-coding RNAs in human choriocarcinomaChoriocarcinomaLncRNA-based therapyLong non-coding RNAOncogenes or tumor suppressor genesRare cancerCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action.Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNDi Fiore, RiccardoSuleiman, SherifFelix, AnaO’toole, Sharon A.O’leary, John J.Ward, Mark P.Beirne, JamesSabol, MajaOzretić, PetarYordanov, AngelVasileva-Slaveva, MarielaKostov, StoyanNikolova, MargaritaSaid-Huntingford, IanAyers, DuncanEllul, BridgetPentimalli, FrancescaGiordano, AntonioCalleja-Agius, Jean2021-07-05T22:18:22Z2021-06-022021-06-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/120547eng1661-6596PURE: 32161602https://doi.org/10.3390/ijms22126506info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:54:25Zoai:run.unl.pt:10362/120547Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:25:20.647932Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| title |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| spellingShingle |
An overview of the role of long non-coding RNAs in human choriocarcinoma Di Fiore, Riccardo Choriocarcinoma LncRNA-based therapy Long non-coding RNA Oncogenes or tumor suppressor genes Rare cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| title_short |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| title_full |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| title_fullStr |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| title_full_unstemmed |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| title_sort |
An overview of the role of long non-coding RNAs in human choriocarcinoma |
| author |
Di Fiore, Riccardo |
| author_facet |
Di Fiore, Riccardo Suleiman, Sherif Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Sabol, Maja Ozretić, Petar Yordanov, Angel Vasileva-Slaveva, Mariela Kostov, Stoyan Nikolova, Margarita Said-Huntingford, Ian Ayers, Duncan Ellul, Bridget Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| author_role |
author |
| author2 |
Suleiman, Sherif Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Sabol, Maja Ozretić, Petar Yordanov, Angel Vasileva-Slaveva, Mariela Kostov, Stoyan Nikolova, Margarita Said-Huntingford, Ian Ayers, Duncan Ellul, Bridget Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Di Fiore, Riccardo Suleiman, Sherif Felix, Ana O’toole, Sharon A. O’leary, John J. Ward, Mark P. Beirne, James Sabol, Maja Ozretić, Petar Yordanov, Angel Vasileva-Slaveva, Mariela Kostov, Stoyan Nikolova, Margarita Said-Huntingford, Ian Ayers, Duncan Ellul, Bridget Pentimalli, Francesca Giordano, Antonio Calleja-Agius, Jean |
| dc.subject.por.fl_str_mv |
Choriocarcinoma LncRNA-based therapy Long non-coding RNA Oncogenes or tumor suppressor genes Rare cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| topic |
Choriocarcinoma LncRNA-based therapy Long non-coding RNA Oncogenes or tumor suppressor genes Rare cancer Catalysis Molecular Biology Spectroscopy Computer Science Applications Physical and Theoretical Chemistry Organic Chemistry Inorganic Chemistry SDG 3 - Good Health and Well-being |
| description |
Funding: The publication of this manuscript was funded by the European Cooperation in Science & Technology Program (EU COST)–COST Action CA18117: GYNOCARE- “European network for Gynaecological Rare Cancer research: From Concept to Cure”. R.D.F., S.S., A.F., S.A.O., J.J.O., M.P.W., J.B., M.S., P.O., A.Y., M.V.-S., B.E., A.G., and J.C.-A. are Action management committee members and/or form part of Working Groups 1–3, and J.C.-A. is the Chairperson of this Action. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-07-05T22:18:22Z 2021-06-02 2021-06-02T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/other |
| format |
other |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/120547 |
| url |
http://hdl.handle.net/10362/120547 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1661-6596 PURE: 32161602 https://doi.org/10.3390/ijms22126506 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP |
| instname_str |
FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| collection |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| repository.name.fl_str_mv |
Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
| repository.mail.fl_str_mv |
info@rcaap.pt |
| _version_ |
1833596684478709760 |