Differential unfolded protein response regulation in KRAS silencing sensitive and innately resistant colorectal cancer cells

• Main Author: Martins, Flávia
• Publication Date: 2025
• Other Authors: Machado, Ana L., Carvalho, Joana, Almeida, Catarina R., Beck, Hans C., Carvalho, Ana S., Backman, Vadim, Matthiesen, Rune, Velho, Sérgia
• Format: Article
• Language: eng
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: http://hdl.handle.net/10362/182833
• topic: General; SDG 3 - Good Health and Well-being

Funding Information: The work was funded by internal grants (MSI and Cancer Challenge 2022) provided by the Institute for Molecular Pathology and Immunology of the University of Porto (IPATIMUP) and by national funds through FCT in the scope of the project 2022.05346.PTDC (https://doi.org/10.54499/2022.05346.PTDC). This article is also a result of the projects (iNOVA4Health\u2013UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia / Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior. FM is a Ph.D. student in the Doctoral Program in Biomedicine at the Faculty of Medicine of the University of Porto, and she is funded through a Ph.D. fellowship (SFRH/BD/143669/2019) awarded by the Portuguese Foundation for Science and Technology (FCT). ALM is a Ph.D. student in the Doctoral Program in Biomedicine from the Faculty of Medicine of the University of Porto, and she is funded through a Ph.D. fellowship (2020.08932.BD) awarded by the FCT. JC is hired by IPATIMUP under norma transit\u00F3ria do DL n.\u00B0 57/2016 alterada pela lei n.\u00B0 57/2017 (https://doi.org/10.54499/DL57/2016/CP1363/CT0012). CA was financially supported by national funds (OE), through Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT)/MCTES, within the scope of iBiMED\u2014Institute of Biomedicine (https://doi.org/10.54499/UIDP/04501/2020). ASC is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (https://doi.org/10.54499/DL57/2016/CP1457/CT0013). VB was supported by NIH grants R01CA228272, R02CA225002,\u00A0U54CA268084, and U54CA261694, NSF grant EFMA1830961, the Center for Physical Genomics and Engineering at Northwestern University, and philanthropic support from K. Hudson and R. Goldman, S. Brice and J. Esteve, M. E. Holliday and I. Schneider, the Christina Carinato Charitable Foundation, and D. Sachs. RM is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (CEEC position, https://doi.org/10.54499/CEECIND/03906/2017/CP1421/CT0004). SV is supported by FCT (https://doi.org/10.54499/2021.01550.CEECIND/CP1663/CT0012). Funding Information: The work was funded by internal grants (MSI and Cancer Challenge 2022) provided by the Institute for Molecular Pathology and Immunology of the University of Porto (IPATIMUP) and by national funds through FCT in the scope of the project 2022.05346.PTDC ( https://doi.org/10.54499/2022.05346.PTDC ). This article is also a result of the projects (iNOVA4Health\u2013UIDB/04462/2020 and UIDP/04462/2020, and by the Associated Laboratory LS4FUTURE (LA/P/0087/2020), two programs financially supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia / Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior. FM is a Ph.D. student in the Doctoral Program in Biomedicine at the Faculty of Medicine of the University of Porto, and she is funded through a Ph.D. fellowship (SFRH/BD/143669/2019) awarded by the Portuguese Foundation for Science and Technology (FCT). ALM is a Ph.D. student in the Doctoral Program in Biomedicine from the Faculty of Medicine of the University of Porto, and she is funded through a Ph.D. fellowship (2020.08932.BD) awarded by the FCT. JC is hired by IPATIMUP under norma transit\u00F3ria do DL n.\u00B0 57/2016 alterada pela lei n.\u00B0 57/2017 ( https://doi.org/10.54499/DL57/2016/CP1363/CT0012 ). CA was financially supported by national funds (OE), through Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT)/MCTES, within the scope of iBiMED\u2014Institute of Biomedicine ( https://doi.org/10.54499/UIDP/04501/2020 ). ASC is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia ( https://doi.org/10.54499/DL57/2016/CP1457/CT0013 ). VB was supported by NIH grants R01CA228272, R02CA225002, U54CA268084, and U54CA261694, NSF grant EFMA1830961, the Center for Physical Genomics and Engineering at Northwestern University, and philanthropic support from K. Hudson and R. Goldman, S. Brice and J. Esteve, M. E. Holliday and I. Schneider, the Christina Carinato Charitable Foundation, and D. Sachs. RM is supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (CEEC position, https://doi.org/10.54499/CEECIND/03906/2017/CP1421/CT0004 ). SV is supported by FCT ( https://doi.org/10.54499/2021.01550.CEECIND/CP1663/CT0012 ). Funding Information: The authors acknowledge the support of Catarina Meireles and Emilia Cardoso from the Translational Cytometry unit (TraCy) i3S Scientific Platform. We acknowledge the COST Action CA20113 \u201CPROTEOCURE\u201D supported by COST (European Cooperation in Science and Technology). Publisher Copyright: © The Author(s) 2025.