Tuning of paroxetine 3D-printable formulations for fused deposition modelling

Bibliographic Details
Main Author: Figueiredo, Sara
Publication Date: 2021
Other Authors: Pinto, João F., Carvalho, Fátima G., Fernandes, Ana Isabel
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10400.26/40607
Summary: This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation containing paroxetine (30% w/w), hydroxypropylcellulose (54% w/w) and excipients (16% w/w of dicalcium dihydrate phosphate, magnesium stearate and triethylcitrate; 10:1:5 ratio) exhibited the most suitable behaviour to be extruded and 3D printed, proving that adjuvants are critical to ensure processing of the formulations.
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spelling Tuning of paroxetine 3D-printable formulations for fused deposition modellingExtrudabilityFilamentPrintability3D-printed tabletFused deposition modelling (FDM)Hot melt extrusion (HME)Paroxetine (PRX)This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation containing paroxetine (30% w/w), hydroxypropylcellulose (54% w/w) and excipients (16% w/w of dicalcium dihydrate phosphate, magnesium stearate and triethylcitrate; 10:1:5 ratio) exhibited the most suitable behaviour to be extruded and 3D printed, proving that adjuvants are critical to ensure processing of the formulations.MDPIRepositório ComumFigueiredo, SaraPinto, João F.Carvalho, Fátima G.Fernandes, Ana Isabel2022-05-18T11:03:31Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10400.26/40607eng978-3-0365-2238-8978-3-0365-2237-12673-999210.3390/msf2021005017info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-01T16:52:38Zoai:comum.rcaap.pt:10400.26/40607Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-29T04:45:41.578252Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Tuning of paroxetine 3D-printable formulations for fused deposition modelling
title Tuning of paroxetine 3D-printable formulations for fused deposition modelling
spellingShingle Tuning of paroxetine 3D-printable formulations for fused deposition modelling
Figueiredo, Sara
Extrudability
Filament
Printability
3D-printed tablet
Fused deposition modelling (FDM)
Hot melt extrusion (HME)
Paroxetine (PRX)
title_short Tuning of paroxetine 3D-printable formulations for fused deposition modelling
title_full Tuning of paroxetine 3D-printable formulations for fused deposition modelling
title_fullStr Tuning of paroxetine 3D-printable formulations for fused deposition modelling
title_full_unstemmed Tuning of paroxetine 3D-printable formulations for fused deposition modelling
title_sort Tuning of paroxetine 3D-printable formulations for fused deposition modelling
author Figueiredo, Sara
author_facet Figueiredo, Sara
Pinto, João F.
Carvalho, Fátima G.
Fernandes, Ana Isabel
author_role author
author2 Pinto, João F.
Carvalho, Fátima G.
Fernandes, Ana Isabel
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Figueiredo, Sara
Pinto, João F.
Carvalho, Fátima G.
Fernandes, Ana Isabel
dc.subject.por.fl_str_mv Extrudability
Filament
Printability
3D-printed tablet
Fused deposition modelling (FDM)
Hot melt extrusion (HME)
Paroxetine (PRX)
topic Extrudability
Filament
Printability
3D-printed tablet
Fused deposition modelling (FDM)
Hot melt extrusion (HME)
Paroxetine (PRX)
description This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation containing paroxetine (30% w/w), hydroxypropylcellulose (54% w/w) and excipients (16% w/w of dicalcium dihydrate phosphate, magnesium stearate and triethylcitrate; 10:1:5 ratio) exhibited the most suitable behaviour to be extruded and 3D printed, proving that adjuvants are critical to ensure processing of the formulations.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-05-18T11:03:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/40607
url http://hdl.handle.net/10400.26/40607
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 978-3-0365-2238-8
978-3-0365-2237-1
2673-9992
10.3390/msf2021005017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833602144159137792

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