Platelet transfusions in adult ICU patients with thrombocytopenia

Bibliographic Details
Main Author: Anthon, Carl Thomas
Publication Date: 2024
Other Authors: Pène, Frédéric, Perner, Anders, Azoulay, Elie, Puxty, Kathryn, Van De Louw, Andry, Chawla, Sanjay, Castro, Pedro, Povoa, Pedro, Coelho, Luis, Metaxa, Victoria, Kochanek, Matthias, Liebregts, Tobias, Kander, Thomas, Sivula, Mirka, Andreasen, Jo Bønding, Nielsen, Lene Bjerregaard, Hvas, Christine Lodberg, Dufranc, Etienne, Canet, Emmanuel, Wright, Christopher John, Schmidt, Julien, Uhel, Fabrice, Missri, Louai, Krag, Mette, Cos Badia, Elisabet, Díaz-Lagares, Cándido, Menat, Sophie, Voiriot, Guillaume, Erikstrup Clausen, Niels, Lorentzen, Kristian, Kvåle, Reidar, Barratt-Due, Andreas, Hildebrandt, Thomas, Holten, Aleksander Rygh, Strand, Kristian, Bestle, Morten Heiberg, Klepstad, Pål, Vimpere, Damien, Paulino, Carolina, Lueck, Catherina, Juhl, Christian Svendsen, Costa, Carolina, Bådstøløkken, Per Martin, Lêdo, Lia Susana Aires, Møller, Morten Hylander, Russell, Lene
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/168821
Summary: Funding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
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spelling Platelet transfusions in adult ICU patients with thrombocytopeniaA sub-study of the PLOT-ICU inception cohort studycritical illnessintensive care unitplatelet transfusionthrombocytopeniaAnesthesiology and Pain MedicineFunding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.Background: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown. Study design and methods: Sub-study of the inception cohort study ‘Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)’, including acutely admitted, adult ICU patients with thrombocytopenia (platelet count <150 × 109/L). The primary outcome was the number of patients receiving platelet transfusion in ICU by product type. Secondary outcomes included platelet transfusion details, platelet increments, bleeding, other transfusions and mortality. Results: Amongst 504 patients with thrombocytopenia from 43 hospitals in 10 countries in Europe and the United States, 20.8% received 565 platelet transfusions; 61.0% received pooled products, 21.9% received apheresis products and 17.1% received both with a median of 2 (interquartile range 1–4) days from admission to first transfusion. The median volume per transfusion was 253 mL (180–308 mL) and pooled products accounted for 59.1% of transfusions, however, this varied across countries. Most centres (73.8%) used fixed dosing (medians ranging from 2.0 to 3.5 × 1011 platelets/transfusion) whilst some (mainly in France) used weight-based dosing (ranging from 0.5 to 0.7 × 1011 platelets per 10 kg body weight). The median platelet count increment for a single prophylactic platelet transfusion was 2 (−1 to 8) × 109/L. Outcomes of patients with thrombocytopenia who did and did not receive platelet transfusions varied. Conclusions: Among acutely admitted, adult ICU patients with thrombocytopenia, 20.8% received platelet transfusions in ICU of whom most received pooled products, but considerable variation was observed in product type, volumes and doses across countries. Prophylactic platelet transfusions were associated with limited increases in platelet counts.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAnthon, Carl ThomasPène, FrédéricPerner, AndersAzoulay, EliePuxty, KathrynVan De Louw, AndryChawla, SanjayCastro, PedroPovoa, PedroCoelho, LuisMetaxa, VictoriaKochanek, MatthiasLiebregts, TobiasKander, ThomasSivula, MirkaAndreasen, Jo BøndingNielsen, Lene BjerregaardHvas, Christine LodbergDufranc, EtienneCanet, EmmanuelWright, Christopher JohnSchmidt, JulienUhel, FabriceMissri, LouaiKrag, MetteCos Badia, ElisabetDíaz-Lagares, CándidoMenat, SophieVoiriot, GuillaumeErikstrup Clausen, NielsLorentzen, KristianKvåle, ReidarBarratt-Due, AndreasHildebrandt, ThomasHolten, Aleksander RyghStrand, KristianBestle, Morten HeibergKlepstad, PålVimpere, DamienPaulino, CarolinaLueck, CatherinaJuhl, Christian SvendsenCosta, CarolinaBådstøløkken, Per MartinLêdo, Lia Susana AiresMøller, Morten HylanderRussell, Lene2024-06-20T00:38:45Z2024-092024-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/168821eng0001-5172PURE: 93416357https://doi.org/10.1111/aas.14467info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:41:17Zoai:run.unl.pt:10362/168821Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:56:23.250102Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Platelet transfusions in adult ICU patients with thrombocytopenia
A sub-study of the PLOT-ICU inception cohort study
title Platelet transfusions in adult ICU patients with thrombocytopenia
spellingShingle Platelet transfusions in adult ICU patients with thrombocytopenia
Anthon, Carl Thomas
critical illness
intensive care unit
platelet transfusion
thrombocytopenia
Anesthesiology and Pain Medicine
title_short Platelet transfusions in adult ICU patients with thrombocytopenia
title_full Platelet transfusions in adult ICU patients with thrombocytopenia
title_fullStr Platelet transfusions in adult ICU patients with thrombocytopenia
title_full_unstemmed Platelet transfusions in adult ICU patients with thrombocytopenia
title_sort Platelet transfusions in adult ICU patients with thrombocytopenia
author Anthon, Carl Thomas
author_facet Anthon, Carl Thomas
Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Sivula, Mirka
Andreasen, Jo Bønding
Nielsen, Lene Bjerregaard
Hvas, Christine Lodberg
Dufranc, Etienne
Canet, Emmanuel
Wright, Christopher John
Schmidt, Julien
Uhel, Fabrice
Missri, Louai
Krag, Mette
Cos Badia, Elisabet
Díaz-Lagares, Cándido
Menat, Sophie
Voiriot, Guillaume
Erikstrup Clausen, Niels
Lorentzen, Kristian
Kvåle, Reidar
Barratt-Due, Andreas
Hildebrandt, Thomas
Holten, Aleksander Rygh
Strand, Kristian
Bestle, Morten Heiberg
Klepstad, Pål
Vimpere, Damien
Paulino, Carolina
Lueck, Catherina
Juhl, Christian Svendsen
Costa, Carolina
Bådstøløkken, Per Martin
Lêdo, Lia Susana Aires
Møller, Morten Hylander
Russell, Lene
author_role author
author2 Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Sivula, Mirka
Andreasen, Jo Bønding
Nielsen, Lene Bjerregaard
Hvas, Christine Lodberg
Dufranc, Etienne
Canet, Emmanuel
Wright, Christopher John
Schmidt, Julien
Uhel, Fabrice
Missri, Louai
Krag, Mette
Cos Badia, Elisabet
Díaz-Lagares, Cándido
Menat, Sophie
Voiriot, Guillaume
Erikstrup Clausen, Niels
Lorentzen, Kristian
Kvåle, Reidar
Barratt-Due, Andreas
Hildebrandt, Thomas
Holten, Aleksander Rygh
Strand, Kristian
Bestle, Morten Heiberg
Klepstad, Pål
Vimpere, Damien
Paulino, Carolina
Lueck, Catherina
Juhl, Christian Svendsen
Costa, Carolina
Bådstøløkken, Per Martin
Lêdo, Lia Susana Aires
Møller, Morten Hylander
Russell, Lene
author2_role author
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author
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author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Anthon, Carl Thomas
Pène, Frédéric
Perner, Anders
Azoulay, Elie
Puxty, Kathryn
Van De Louw, Andry
Chawla, Sanjay
Castro, Pedro
Povoa, Pedro
Coelho, Luis
Metaxa, Victoria
Kochanek, Matthias
Liebregts, Tobias
Kander, Thomas
Sivula, Mirka
Andreasen, Jo Bønding
Nielsen, Lene Bjerregaard
Hvas, Christine Lodberg
Dufranc, Etienne
Canet, Emmanuel
Wright, Christopher John
Schmidt, Julien
Uhel, Fabrice
Missri, Louai
Krag, Mette
Cos Badia, Elisabet
Díaz-Lagares, Cándido
Menat, Sophie
Voiriot, Guillaume
Erikstrup Clausen, Niels
Lorentzen, Kristian
Kvåle, Reidar
Barratt-Due, Andreas
Hildebrandt, Thomas
Holten, Aleksander Rygh
Strand, Kristian
Bestle, Morten Heiberg
Klepstad, Pål
Vimpere, Damien
Paulino, Carolina
Lueck, Catherina
Juhl, Christian Svendsen
Costa, Carolina
Bådstøløkken, Per Martin
Lêdo, Lia Susana Aires
Møller, Morten Hylander
Russell, Lene
dc.subject.por.fl_str_mv critical illness
intensive care unit
platelet transfusion
thrombocytopenia
Anesthesiology and Pain Medicine
topic critical illness
intensive care unit
platelet transfusion
thrombocytopenia
Anesthesiology and Pain Medicine
description Funding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-20T00:38:45Z
2024-09
2024-09-01T00:00:00Z
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 0001-5172
PURE: 93416357
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