Platelet transfusions in adult ICU patients with thrombocytopenia
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Publication Date: | 2024 |
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Language: | eng |
Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
Download full: | http://hdl.handle.net/10362/168821 |
Summary: | Funding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. |
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Platelet transfusions in adult ICU patients with thrombocytopeniaA sub-study of the PLOT-ICU inception cohort studycritical illnessintensive care unitplatelet transfusionthrombocytopeniaAnesthesiology and Pain MedicineFunding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.Background: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown. Study design and methods: Sub-study of the inception cohort study ‘Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)’, including acutely admitted, adult ICU patients with thrombocytopenia (platelet count <150 × 109/L). The primary outcome was the number of patients receiving platelet transfusion in ICU by product type. Secondary outcomes included platelet transfusion details, platelet increments, bleeding, other transfusions and mortality. Results: Amongst 504 patients with thrombocytopenia from 43 hospitals in 10 countries in Europe and the United States, 20.8% received 565 platelet transfusions; 61.0% received pooled products, 21.9% received apheresis products and 17.1% received both with a median of 2 (interquartile range 1–4) days from admission to first transfusion. The median volume per transfusion was 253 mL (180–308 mL) and pooled products accounted for 59.1% of transfusions, however, this varied across countries. Most centres (73.8%) used fixed dosing (medians ranging from 2.0 to 3.5 × 1011 platelets/transfusion) whilst some (mainly in France) used weight-based dosing (ranging from 0.5 to 0.7 × 1011 platelets per 10 kg body weight). The median platelet count increment for a single prophylactic platelet transfusion was 2 (−1 to 8) × 109/L. Outcomes of patients with thrombocytopenia who did and did not receive platelet transfusions varied. Conclusions: Among acutely admitted, adult ICU patients with thrombocytopenia, 20.8% received platelet transfusions in ICU of whom most received pooled products, but considerable variation was observed in product type, volumes and doses across countries. Prophylactic platelet transfusions were associated with limited increases in platelet counts.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAnthon, Carl ThomasPène, FrédéricPerner, AndersAzoulay, EliePuxty, KathrynVan De Louw, AndryChawla, SanjayCastro, PedroPovoa, PedroCoelho, LuisMetaxa, VictoriaKochanek, MatthiasLiebregts, TobiasKander, ThomasSivula, MirkaAndreasen, Jo BøndingNielsen, Lene BjerregaardHvas, Christine LodbergDufranc, EtienneCanet, EmmanuelWright, Christopher JohnSchmidt, JulienUhel, FabriceMissri, LouaiKrag, MetteCos Badia, ElisabetDíaz-Lagares, CándidoMenat, SophieVoiriot, GuillaumeErikstrup Clausen, NielsLorentzen, KristianKvåle, ReidarBarratt-Due, AndreasHildebrandt, ThomasHolten, Aleksander RyghStrand, KristianBestle, Morten HeibergKlepstad, PålVimpere, DamienPaulino, CarolinaLueck, CatherinaJuhl, Christian SvendsenCosta, CarolinaBådstøløkken, Per MartinLêdo, Lia Susana AiresMøller, Morten HylanderRussell, Lene2024-06-20T00:38:45Z2024-092024-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/168821eng0001-5172PURE: 93416357https://doi.org/10.1111/aas.14467info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-05-26T01:41:17Zoai:run.unl.pt:10362/168821Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:56:23.250102Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
dc.title.none.fl_str_mv |
Platelet transfusions in adult ICU patients with thrombocytopenia A sub-study of the PLOT-ICU inception cohort study |
title |
Platelet transfusions in adult ICU patients with thrombocytopenia |
spellingShingle |
Platelet transfusions in adult ICU patients with thrombocytopenia Anthon, Carl Thomas critical illness intensive care unit platelet transfusion thrombocytopenia Anesthesiology and Pain Medicine |
title_short |
Platelet transfusions in adult ICU patients with thrombocytopenia |
title_full |
Platelet transfusions in adult ICU patients with thrombocytopenia |
title_fullStr |
Platelet transfusions in adult ICU patients with thrombocytopenia |
title_full_unstemmed |
Platelet transfusions in adult ICU patients with thrombocytopenia |
title_sort |
Platelet transfusions in adult ICU patients with thrombocytopenia |
author |
Anthon, Carl Thomas |
author_facet |
Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Chawla, Sanjay Castro, Pedro Povoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Sivula, Mirka Andreasen, Jo Bønding Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Wright, Christopher John Schmidt, Julien Uhel, Fabrice Missri, Louai Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Erikstrup Clausen, Niels Lorentzen, Kristian Kvåle, Reidar Barratt-Due, Andreas Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Bestle, Morten Heiberg Klepstad, Pål Vimpere, Damien Paulino, Carolina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Lêdo, Lia Susana Aires Møller, Morten Hylander Russell, Lene |
author_role |
author |
author2 |
Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Chawla, Sanjay Castro, Pedro Povoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Sivula, Mirka Andreasen, Jo Bønding Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Wright, Christopher John Schmidt, Julien Uhel, Fabrice Missri, Louai Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Erikstrup Clausen, Niels Lorentzen, Kristian Kvåle, Reidar Barratt-Due, Andreas Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Bestle, Morten Heiberg Klepstad, Pål Vimpere, Damien Paulino, Carolina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Lêdo, Lia Susana Aires Møller, Morten Hylander Russell, Lene |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Chawla, Sanjay Castro, Pedro Povoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Sivula, Mirka Andreasen, Jo Bønding Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Wright, Christopher John Schmidt, Julien Uhel, Fabrice Missri, Louai Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Erikstrup Clausen, Niels Lorentzen, Kristian Kvåle, Reidar Barratt-Due, Andreas Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Bestle, Morten Heiberg Klepstad, Pål Vimpere, Damien Paulino, Carolina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Lêdo, Lia Susana Aires Møller, Morten Hylander Russell, Lene |
dc.subject.por.fl_str_mv |
critical illness intensive care unit platelet transfusion thrombocytopenia Anesthesiology and Pain Medicine |
topic |
critical illness intensive care unit platelet transfusion thrombocytopenia Anesthesiology and Pain Medicine |
description |
Funding Information: This study was funded by the Research Council of Rigshospitalet, the Ehrenreich's Foundation and the Dagmar Marshalls Foundation. None of the funders had any influence on the design, conduct or reporting of the study. Funding Information: The Department of Intensive Care at Rigshospitalet (CTA, AP, MHM, LR) has received funding for other research projects from Sygeforsikringen \u2018danmark\u2019, and the Novo Nordisk Foundation. FP has received honoraria for consulting and lectures from Gilead and an institutional grant from Alexion Pharma. AP has received honorarium from Novartis for participation in an advisory board. EA has received research grants from MSD Avenir and Alexion and honoraria for lectures from Alexion, Sanofi and Pfizer. AVDL has received honoraria from Sanofi for participation in an advisory board. PC has received consulting fees from Sanofi, Gilead, Alexion and Janssen and honoraria for lectures from Merck Sharp & Dohme, Gilead, Alexion and Pfizer. PP has received consulting fees from Sanofi and Gilead and honoraria from Merck Sharp & Dohme, Gilead, Mundipharma and Pfizer for academic and educational work. EC received fees for lectures and conference talks and had travel and accommodation expenses related to attending scientific meetings covered by Gilead, Shionogi B.V. and Sanofi\u2010Genzyme. ARH has received honoraria from Pfizer for lectures. MHB has received consulting fees from AM\u2010pharma and Inotrem. CL has received consulting fees from Gilead. MS has received honoraria for lectures and consulting from CSL Behring, Alexion AstraZeneca Rare Disease and Takeda. KS has received consulting fees from Paion. None of these had any relation to the current work. Publisher Copyright: © 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-06-20T00:38:45Z 2024-09 2024-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/168821 |
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eng |
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eng |
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0001-5172 PURE: 93416357 https://doi.org/10.1111/aas.14467 |
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openAccess |
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