The gray area between operational tolerance and overt rejection in kidney transplantation

Bibliographic Details
Main Author: Silva,Rui F.
Publication Date: 2021
Other Authors: Relvas,Miguel L., Nunes,Ana, Silvano,José L., Beco,Ana, Bustorff,Manuela B., Sampaio,Susana M.
Format: Report
Language: por
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260
Summary: ABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management.
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spelling The gray area between operational tolerance and overt rejection in kidney transplantationkidney transplantationoperational toleranceantibody mediated rejectionABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management.Sociedade Portuguesa de Nefrologia2021-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260Portuguese Journal of Nephrology &amp; Hypertension v.35 n.4 2021reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAPporhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260Silva,Rui F.Relvas,Miguel L.Nunes,AnaSilvano,José L.Beco,AnaBustorff,Manuela B.Sampaio,Susana M.info:eu-repo/semantics/openAccess2024-02-06T17:05:12Zoai:scielo:S0872-01692021000400260Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T12:54:39.464207Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv The gray area between operational tolerance and overt rejection in kidney transplantation
title The gray area between operational tolerance and overt rejection in kidney transplantation
spellingShingle The gray area between operational tolerance and overt rejection in kidney transplantation
Silva,Rui F.
kidney transplantation
operational tolerance
antibody mediated rejection
title_short The gray area between operational tolerance and overt rejection in kidney transplantation
title_full The gray area between operational tolerance and overt rejection in kidney transplantation
title_fullStr The gray area between operational tolerance and overt rejection in kidney transplantation
title_full_unstemmed The gray area between operational tolerance and overt rejection in kidney transplantation
title_sort The gray area between operational tolerance and overt rejection in kidney transplantation
author Silva,Rui F.
author_facet Silva,Rui F.
Relvas,Miguel L.
Nunes,Ana
Silvano,José L.
Beco,Ana
Bustorff,Manuela B.
Sampaio,Susana M.
author_role author
author2 Relvas,Miguel L.
Nunes,Ana
Silvano,José L.
Beco,Ana
Bustorff,Manuela B.
Sampaio,Susana M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Rui F.
Relvas,Miguel L.
Nunes,Ana
Silvano,José L.
Beco,Ana
Bustorff,Manuela B.
Sampaio,Susana M.
dc.subject.por.fl_str_mv kidney transplantation
operational tolerance
antibody mediated rejection
topic kidney transplantation
operational tolerance
antibody mediated rejection
description ABSTRACT Operational tolerance in kidney transplantation is characterized by stable serum creatinine < 1.7 mg/dL and proteinuria < 1 g/day in the absence of immunosuppression or immunodeficiency for over one year. However, simultaneous donor specific antibodies are common and serum creatinine is a poor surrogate of early lesions. Consequently, subclinical rejections will meet operational tolerance criteria if sérum creatinine remains stable. We report a patient with operational tolerance criteria followed by biopsy-proven chronic active antibody mediated rejection, discussing the intricate challenges of immunosuppression management.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692021000400260
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology &amp; Hypertension v.35 n.4 2021
reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833593240775819264

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