Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction

Bibliographic Details
Main Author: Timóteo, Ana Teresa
Publication Date: 2024
Other Authors: Branco, Luísa Moura, Galrinho, Ana, Rio, Pedro, Papoila, Ana Luísa, Alves, Marta, Ferreira, Rui Cruz
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/163129
Summary: Publisher Copyright: © 2024 The Author
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network_acronym_str RCAP
network_name_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str https://opendoar.ac.uk/repository/7160
spelling Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarctionMyocardial infarctionMyocardial workPrognosisStrainCardiology and Cardiovascular MedicinePublisher Copyright: © 2024 The AuthorBackground: Left ventricular global longitudinal strain (GLS) has incremental prognostic value over ejection fraction (EF) in patients with ST-segment-elevation myocardial infarction (STEMI), but it is also load dependent. It has been recently demonstrated that Myocardial work (MW), integrating blood pressure with GLS, predicts long-term all-cause mortality. We aimed to further explore the prognostic value of MW for cardiovascular endpoints in patients with STEMI. Methods and results: Retrospective study of 200 consecutive patients admitted with a STEMI, mean age of 62 (SD 12) years, 79.5% males, that survived to discharge. Transthoracic echocardiography was performed before discharge (5 ± 3 days after admission). Mean follow-up was 790 days. The primary outcome was a composite of cardiovascular death, non-fatal myocardial infarction, and unplanned cardiovascular admission (ACE). During follow-up, 26 patients had a ACE. In univariable Cox regression analysis, male gender, body mass index, GRACE risk score and Global Work Index (GWI) were selected to the multivariable analysis, in which, only GWI (per 100 mmHg% decrease: hazard ratio estimate 1.19, 95% confidence interval 1.07–1.34, p-value = 0.002) remained independently associated with ACE, with effective reclassification of non-events. The best GWI cut-off to predict ACE was ≤1165 mmHg% (Log-rank, p = 0.034). Conclusions: LV GWI is independently associated with medium-term ACE. Nevertheless, prospective studies in a larger sample of patients are warranted to confirm this finding.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNTimóteo, Ana TeresaBranco, Luísa MouraGalrinho, AnaRio, PedroPapoila, Ana LuísaAlves, MartaFerreira, Rui Cruz2024-02-06T00:09:26Z2024-03-152024-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163129eng0167-5273PURE: 82511147https://doi.org/10.1016/j.ijcard.2024.131781info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-01-13T01:40:04Zoai:run.unl.pt:10362/163129Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:48:44.658622Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
title Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
spellingShingle Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
Timóteo, Ana Teresa
Myocardial infarction
Myocardial work
Prognosis
Strain
Cardiology and Cardiovascular Medicine
title_short Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
title_full Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
title_fullStr Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
title_full_unstemmed Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
title_sort Global left ventricular myocardial work index and medium-term adverse cardiovascular events after ST-elevation myocardial infarction
author Timóteo, Ana Teresa
author_facet Timóteo, Ana Teresa
Branco, Luísa Moura
Galrinho, Ana
Rio, Pedro
Papoila, Ana Luísa
Alves, Marta
Ferreira, Rui Cruz
author_role author
author2 Branco, Luísa Moura
Galrinho, Ana
Rio, Pedro
Papoila, Ana Luísa
Alves, Marta
Ferreira, Rui Cruz
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Timóteo, Ana Teresa
Branco, Luísa Moura
Galrinho, Ana
Rio, Pedro
Papoila, Ana Luísa
Alves, Marta
Ferreira, Rui Cruz
dc.subject.por.fl_str_mv Myocardial infarction
Myocardial work
Prognosis
Strain
Cardiology and Cardiovascular Medicine
topic Myocardial infarction
Myocardial work
Prognosis
Strain
Cardiology and Cardiovascular Medicine
description Publisher Copyright: © 2024 The Author
publishDate 2024
dc.date.none.fl_str_mv 2024-02-06T00:09:26Z
2024-03-15
2024-03-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163129
url http://hdl.handle.net/10362/163129
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0167-5273
PURE: 82511147
https://doi.org/10.1016/j.ijcard.2024.131781
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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