Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys
| Main Author: | |
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| Publication Date: | 2024 |
| Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Other |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/174810 |
Summary: | The World Health Organization World Mental Health (WMH) Survey Initiative is supported by the United States National Institute of Mental Health (NIMH; R01 MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the United States Public Health Service (R13-MH066849, R01-MH069864, and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, Ortho-McNeil Pharmaceutical Inc., GlaxoSmithKline, and Bristol-Myers Squibb. We thank the staff of the WMH Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, fieldwork, and consultation on data analysis. None of the funders had any role in the design, analysis, interpretation of results, or preparation of this paper. The views and opinions expressed in this report are those of the authors and should not be construed to represent the views of the World Health Organization, other sponsoring organizations, agencies, or governments. |
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Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveysantidepressantsmajor depressive disordermedication discontinuationSDG 3 - Good Health and Well-beingThe World Health Organization World Mental Health (WMH) Survey Initiative is supported by the United States National Institute of Mental Health (NIMH; R01 MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the United States Public Health Service (R13-MH066849, R01-MH069864, and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, Ortho-McNeil Pharmaceutical Inc., GlaxoSmithKline, and Bristol-Myers Squibb. We thank the staff of the WMH Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, fieldwork, and consultation on data analysis. None of the funders had any role in the design, analysis, interpretation of results, or preparation of this paper. The views and opinions expressed in this report are those of the authors and should not be construed to represent the views of the World Health Organization, other sponsoring organizations, agencies, or governments.BACKGROUND: Despite their documented efficacy, substantial proportions of patients discontinue antidepressant medication (ADM) without a doctor's recommendation. The current report integrates data on patient-reported reasons into an investigation of patterns and predictors of ADM discontinuation. METHODS: Face-to-face interviews with community samples from 13 countries (n = 30 697) in the World Mental Health (WMH) Surveys included n = 1890 respondents who used ADMs within the past 12 months. RESULTS: 10.9% of 12-month ADM users reported discontinuation-based on recommendation of the prescriber while 15.7% discontinued in the absence of prescriber recommendation. The main patient-reported reason for discontinuation was feeling better (46.6%), which was reported by a higher proportion of patients who discontinued within the first 2 weeks of treatment than later. Perceived ineffectiveness (18.5%), predisposing factors (e.g. fear of dependence) (20.0%), and enabling factors (e.g. inability to afford treatment cost) (5.0%) were much less commonly reported reasons. Discontinuation in the absence of prescriber recommendation was associated with low country income level, being employed, and having above average personal income. Age, prior history of psychotropic medication use, and being prescribed treatment from a psychiatrist rather than from a general medical practitioner, in comparison, were associated with a lower probability of this type of discontinuation. However, these predictors varied substantially depending on patient-reported reasons for discontinuation. CONCLUSION: Dropping out early is not necessarily negative with almost half of individuals noting they felt better. The study underscores the diverse reasons given for dropping out and the need to evaluate how and whether dropping out influences short- or long-term functioning.Comprehensive Health Research Centre (CHRC) - pólo NMSNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNKazdin, Alan EHarris, Meredith GHwang, IrvingSampson, Nancy AStein, Dan JViana, Maria CarmenVigo, Daniel VWu, Chi-ShinAguilar-Gaxiola, SergioAlonso, JordiBenjet, CorinaBruffaerts, RonnyCaldas-Almeida, José MiguelCardoso, GracaCaselani, ElisaChardoul, StephanieCía, Alfredode Jonge, PeterGureje, OyeHaro, Josep MariaKaram, Elie GKovess-Masfety, VivianeNavarro-Mateu, FernandoPiazza, MarinaPosada-Villa, JoséScott, Kate MStagnaro, Juan CarlosTen Have, MargreetTorres, YolandaVladescu, CristianKessler, Ronald2024-11-07T22:37:23Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/174810eng0033-2917PURE: 74233165https://doi.org/10.1017/S0033291723002507info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-11-18T01:41:40Zoai:run.unl.pt:10362/174810Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T19:13:00.585472Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| title |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| spellingShingle |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys Kazdin, Alan E antidepressants major depressive disorder medication discontinuation SDG 3 - Good Health and Well-being |
| title_short |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| title_full |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| title_fullStr |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| title_full_unstemmed |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| title_sort |
Patterns, predictors, and patient-reported reasons for antidepressant discontinuation in the WHO World Mental Health Surveys |
| author |
Kazdin, Alan E |
| author_facet |
Kazdin, Alan E Harris, Meredith G Hwang, Irving Sampson, Nancy A Stein, Dan J Viana, Maria Carmen Vigo, Daniel V Wu, Chi-Shin Aguilar-Gaxiola, Sergio Alonso, Jordi Benjet, Corina Bruffaerts, Ronny Caldas-Almeida, José Miguel Cardoso, Graca Caselani, Elisa Chardoul, Stephanie Cía, Alfredo de Jonge, Peter Gureje, Oye Haro, Josep Maria Karam, Elie G Kovess-Masfety, Viviane Navarro-Mateu, Fernando Piazza, Marina Posada-Villa, José Scott, Kate M Stagnaro, Juan Carlos Ten Have, Margreet Torres, Yolanda Vladescu, Cristian Kessler, Ronald |
| author_role |
author |
| author2 |
Harris, Meredith G Hwang, Irving Sampson, Nancy A Stein, Dan J Viana, Maria Carmen Vigo, Daniel V Wu, Chi-Shin Aguilar-Gaxiola, Sergio Alonso, Jordi Benjet, Corina Bruffaerts, Ronny Caldas-Almeida, José Miguel Cardoso, Graca Caselani, Elisa Chardoul, Stephanie Cía, Alfredo de Jonge, Peter Gureje, Oye Haro, Josep Maria Karam, Elie G Kovess-Masfety, Viviane Navarro-Mateu, Fernando Piazza, Marina Posada-Villa, José Scott, Kate M Stagnaro, Juan Carlos Ten Have, Margreet Torres, Yolanda Vladescu, Cristian Kessler, Ronald |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Comprehensive Health Research Centre (CHRC) - pólo NMS NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Kazdin, Alan E Harris, Meredith G Hwang, Irving Sampson, Nancy A Stein, Dan J Viana, Maria Carmen Vigo, Daniel V Wu, Chi-Shin Aguilar-Gaxiola, Sergio Alonso, Jordi Benjet, Corina Bruffaerts, Ronny Caldas-Almeida, José Miguel Cardoso, Graca Caselani, Elisa Chardoul, Stephanie Cía, Alfredo de Jonge, Peter Gureje, Oye Haro, Josep Maria Karam, Elie G Kovess-Masfety, Viviane Navarro-Mateu, Fernando Piazza, Marina Posada-Villa, José Scott, Kate M Stagnaro, Juan Carlos Ten Have, Margreet Torres, Yolanda Vladescu, Cristian Kessler, Ronald |
| dc.subject.por.fl_str_mv |
antidepressants major depressive disorder medication discontinuation SDG 3 - Good Health and Well-being |
| topic |
antidepressants major depressive disorder medication discontinuation SDG 3 - Good Health and Well-being |
| description |
The World Health Organization World Mental Health (WMH) Survey Initiative is supported by the United States National Institute of Mental Health (NIMH; R01 MH070884), the John D. and Catherine T. MacArthur Foundation, the Pfizer Foundation, the United States Public Health Service (R13-MH066849, R01-MH069864, and R01 DA016558), the Fogarty International Center (FIRCA R03-TW006481), the Pan American Health Organization, Eli Lilly and Company, Ortho-McNeil Pharmaceutical Inc., GlaxoSmithKline, and Bristol-Myers Squibb. We thank the staff of the WMH Data Collection and Data Analysis Coordination Centres for assistance with instrumentation, fieldwork, and consultation on data analysis. None of the funders had any role in the design, analysis, interpretation of results, or preparation of this paper. The views and opinions expressed in this report are those of the authors and should not be construed to represent the views of the World Health Organization, other sponsoring organizations, agencies, or governments. |
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2024 |
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2024-11-07T22:37:23Z 2024-01 2024-01-01T00:00:00Z |
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