Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries

Detalhes bibliográficos
Autor(a) principal: Gomes, J
Data de Publicação: 2017
Outros Autores: Mereiter, S, Magalhães, A, Reis, CA
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Texto Completo: https://hdl.handle.net/10216/119040
Resumo: Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
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spelling Early GalNAc O-Glycosylation: Pushing the Tumor BoundariesGlycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.Elsevier (Cell Press)20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://hdl.handle.net/10216/119040eng1535-610810.1016/j.ccell.2017.10.010Gomes, JMereiter, SMagalhães, AReis, CAinfo:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-02-27T18:42:36Zoai:repositorio-aberto.up.pt:10216/119040Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T22:56:23.999858Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
title Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
spellingShingle Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
Gomes, J
title_short Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
title_full Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
title_fullStr Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
title_full_unstemmed Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
title_sort Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
author Gomes, J
author_facet Gomes, J
Mereiter, S
Magalhães, A
Reis, CA
author_role author
author2 Mereiter, S
Magalhães, A
Reis, CA
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomes, J
Mereiter, S
Magalhães, A
Reis, CA
description Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/119040
url https://hdl.handle.net/10216/119040
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1535-6108
10.1016/j.ccell.2017.10.010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier (Cell Press)
publisher.none.fl_str_mv Elsevier (Cell Press)
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
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instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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