Idiopathic Recurring Angioedema: A Possible Case of Hereditary Angioedema Type III

• Main Author: Sales Biermann, Lara
• Publication Date: 2018
• Other Authors: Vasconcelos Lima, Isis, Oliveira Santos, Juliana, Dantas Oliveira, Pedro, Passos Costa, Maite, Aguiar Lima, Katia
• Format: Article
• Language: por
• Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
• Download full: https://doi.org/10.29021/spdv.75.4.689
• topic: Hereditary Angioedema Type III; Tranexamic Acid; Ácido Tranexâmico; Angioedema Hereditário Tipo III; Tranexamic Acid

Three types of hereditary angioedema (HAE) have been described within the spectrum of idioptahic nonhistaminergic angioedema. Type I and II related with C1-INH (C1-esterase inhibitor) deficiency is more frequent and type III is rare, occurs mostly in young women, without C1 inhibitor (C1-INH) alterations, and may be associated with mutations in the factor XII gene. Trauma, stress and estrogen may be the precipitants, treatment is still a challenge due to the absence of controlled studies. We present a case of possible type III HF in a young woman, aggravated by the introduction of anti-conception and improvement with its suspension and treatment with tranexamic acid, but without a family history or a factor XII mutation.