Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries

Bibliographic Details
Main Author: Sherif, Moustafa
Publication Date: 2023
Other Authors: Makame, Khadija Ramadhan, Östlundh, Linda, Paulo, Marilia Silva, Nemmar, Abderrahim, Ali, Bassam R., Al-Rifai, Rami H., Nagy, Károly, Ádám, Balázs
Format: Other
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/157762
Summary: Funding Information: This work is supported by the College of Medicine and Health Sciences (CMHS) of the United Arab Emirates University (UAEU) research grant [Grant number: G00003625]. The contribution of MSS and KRM was supported by the United Arab Emirates University PhD grant and the Stipendium Hungaricum Scholarship Programme, respectively. Publisher Copyright: © 2023 by the authors.
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spelling Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab CountriesA Systematic Review and Meta-AnalysisagricultureArab countriesDNA damagegenotoxicityoccupational exposurepesticideToxicologyHealth, Toxicology and MutagenesisChemical Health and SafetySDG 3 - Good Health and Well-beingFunding Information: This work is supported by the College of Medicine and Health Sciences (CMHS) of the United Arab Emirates University (UAEU) research grant [Grant number: G00003625]. The contribution of MSS and KRM was supported by the United Arab Emirates University PhD grant and the Stipendium Hungaricum Scholarship Programme, respectively. Publisher Copyright: © 2023 by the authors.Exposure to pesticides in Arab countries is a significant public health concern due to extensive agricultural activity and pesticide use. This systematic review aimed to evaluate the genotoxic effects of agricultural pesticide exposure in the region, identify research gaps, and assess methodological limitations. Following the PRISMA guidelines, a comprehensive search yielded five relevant studies conducted in Egypt, Syria, and Jordan. Various genotoxicity assays were employed, revealing a higher level of DNA damage in exposed compared to non-exposed individuals. Farmers exposed to pesticides exhibited a significantly higher occurrence of chromosomal translocation (t(14;18)), micronuclei, and chromosomal aberrations. However, only two studies assessed cytotoxicity indirectly. The studies predominantly focused on male participants, with variations in sample size and pesticide types. The lack of detailed exposure data necessitates cautious interpretation. This review underscores the need for further research on the genotoxicity of occupational pesticide exposure in the Middle East. Future studies should adopt robust study designs, collect biological and environmental samples, conduct repeated sampling, analyze seasonal variations, and encompass diverse study sites associated with specific crop groups.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNSherif, MoustafaMakame, Khadija RamadhanÖstlundh, LindaPaulo, Marilia SilvaNemmar, AbderrahimAli, Bassam R.Al-Rifai, Rami H.Nagy, KárolyÁdám, Balázs2023-09-13T22:18:13Z2023-082023-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/157762eng2305-6304PURE: 71088083https://doi.org/10.3390/toxics11080663info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:14:21Zoai:run.unl.pt:10362/157762Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:44:58.484229Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
A Systematic Review and Meta-Analysis
title Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
spellingShingle Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
Sherif, Moustafa
agriculture
Arab countries
DNA damage
genotoxicity
occupational exposure
pesticide
Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety
SDG 3 - Good Health and Well-being
title_short Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
title_full Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
title_fullStr Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
title_full_unstemmed Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
title_sort Genotoxicity of Occupational Pesticide Exposures among Agricultural Workers in Arab Countries
author Sherif, Moustafa
author_facet Sherif, Moustafa
Makame, Khadija Ramadhan
Östlundh, Linda
Paulo, Marilia Silva
Nemmar, Abderrahim
Ali, Bassam R.
Al-Rifai, Rami H.
Nagy, Károly
Ádám, Balázs
author_role author
author2 Makame, Khadija Ramadhan
Östlundh, Linda
Paulo, Marilia Silva
Nemmar, Abderrahim
Ali, Bassam R.
Al-Rifai, Rami H.
Nagy, Károly
Ádám, Balázs
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Sherif, Moustafa
Makame, Khadija Ramadhan
Östlundh, Linda
Paulo, Marilia Silva
Nemmar, Abderrahim
Ali, Bassam R.
Al-Rifai, Rami H.
Nagy, Károly
Ádám, Balázs
dc.subject.por.fl_str_mv agriculture
Arab countries
DNA damage
genotoxicity
occupational exposure
pesticide
Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety
SDG 3 - Good Health and Well-being
topic agriculture
Arab countries
DNA damage
genotoxicity
occupational exposure
pesticide
Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety
SDG 3 - Good Health and Well-being
description Funding Information: This work is supported by the College of Medicine and Health Sciences (CMHS) of the United Arab Emirates University (UAEU) research grant [Grant number: G00003625]. The contribution of MSS and KRM was supported by the United Arab Emirates University PhD grant and the Stipendium Hungaricum Scholarship Programme, respectively. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-13T22:18:13Z
2023-08
2023-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/157762
url http://hdl.handle.net/10362/157762
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2305-6304
PURE: 71088083
https://doi.org/10.3390/toxics11080663
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
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