HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

Bibliographic Details
Main Author: Jones, Kate
Publication Date: 2022
Other Authors: Galea, Karen S, Scholten, Bernice, Loikala, Marika, Porras, Simo P, Bousoumah, Radia, Ndaw, Sophie, Leese, Elizabeth, Louro, Henriqueta, Silva, Maria João, Viegas, Susana, Godderis, Lode, Verdonck, Jelle, Poels, Katrien, Gӧen, Thomas, Duca, Radu-Corneliu, Santonen, Tiina, Hbm Eu Diisocyanates Study Team
Format: Article
Language: eng
Source: Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full: http://hdl.handle.net/10362/142696
Summary: Funding: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.
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spelling HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational ExposureBiological MonitoringBiomarkersEnvironmental Monitoring/methodsHumansIsocyanates/analysisMouth MucosaOccupational Exposure/analysisFunding: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.Diisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assess occupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl-MDI-lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells (micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygiene measurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Escola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPRUNJones, KateGalea, Karen SScholten, BerniceLoikala, MarikaPorras, Simo PBousoumah, RadiaNdaw, SophieLeese, ElizabethLouro, HenriquetaSilva, Maria JoãoViegas, SusanaGodderis, LodeVerdonck, JellePoels, KatrienGӧen, ThomasDuca, Radu-CorneliuSantonen, TiinaHbm Eu Diisocyanates Study Team2022-07-29T22:25:13Z2022-07-202022-07-20T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/142696eng1660-4601PURE: 45692721https://doi.org/10.3390/ijerph19148811info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:04:09Zoai:run.unl.pt:10362/142696Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:34:42.671809Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
spellingShingle HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
Jones, Kate
Biological Monitoring
Biomarkers
Environmental Monitoring/methods
Humans
Isocyanates/analysis
Mouth Mucosa
Occupational Exposure/analysis
title_short HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_full HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_fullStr HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_full_unstemmed HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
title_sort HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure
author Jones, Kate
author_facet Jones, Kate
Galea, Karen S
Scholten, Bernice
Loikala, Marika
Porras, Simo P
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
Hbm Eu Diisocyanates Study Team
author_role author
author2 Galea, Karen S
Scholten, Bernice
Loikala, Marika
Porras, Simo P
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
Hbm Eu Diisocyanates Study Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centre for Toxicogenomics and Human Health (ToxOmics)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Escola Nacional de Saúde Pública (ENSP)
Centro de Investigação em Saúde Pública (CISP/PHRC)
Comprehensive Health Research Centre (CHRC) - Pólo ENSP
RUN
dc.contributor.author.fl_str_mv Jones, Kate
Galea, Karen S
Scholten, Bernice
Loikala, Marika
Porras, Simo P
Bousoumah, Radia
Ndaw, Sophie
Leese, Elizabeth
Louro, Henriqueta
Silva, Maria João
Viegas, Susana
Godderis, Lode
Verdonck, Jelle
Poels, Katrien
Gӧen, Thomas
Duca, Radu-Corneliu
Santonen, Tiina
Hbm Eu Diisocyanates Study Team
dc.subject.por.fl_str_mv Biological Monitoring
Biomarkers
Environmental Monitoring/methods
Humans
Isocyanates/analysis
Mouth Mucosa
Occupational Exposure/analysis
topic Biological Monitoring
Biomarkers
Environmental Monitoring/methods
Humans
Isocyanates/analysis
Mouth Mucosa
Occupational Exposure/analysis
description Funding: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-29T22:25:13Z
2022-07-20
2022-07-20T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142696
url http://hdl.handle.net/10362/142696
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-4601
PURE: 45692721
https://doi.org/10.3390/ijerph19148811
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron:RCAAP
instname_str FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str RCAAP
institution RCAAP
reponame_str Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv info@rcaap.pt
_version_ 1833596809345236992

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