HBM4EU chromates study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Texto Completo: | http://hdl.handle.net/10362/144376 |
Resumo: | Funding Information: This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Publisher Copyright: © 2022 The Authors |
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HBM4EU chromates studyusefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposureBiological monitoringElectroplatingPlasma chromiumRed blood cells chromiumWeldingWorkplaceBiochemistryEnvironmental Science(all)SDG 3 - Good Health and Well-beingFunding Information: This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Publisher Copyright: © 2022 The AuthorsOccupational exposures to hexavalent Chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P–Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in bath plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P–Cr concentrations. RBC-Cr and P–Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P–Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P–Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context.Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)RUNNdaw, SophieLeso, VerusckaBousoumah, RadiaRémy, AurélieBocca, BeatriceDuca, Radu CorneliuGodderis, LodeHardy, EmilieJanasik, Beatavan Nieuwenhuyse, AnPinhal, HermíniaPoels, KatrienPorras, Simo P.Ruggieri, FlaviaSantonen, TiinaSantos, Sílvia ReisScheepers, Paul T.J.Silva, Maria JoãoVerdonck, JelleViegas, SusanaWasowicz, WojciechIavicoli, Ivo2022-09-28T22:50:46Z2022-112022-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/144376eng0013-9351PURE: 46786494https://doi.org/10.1016/j.envres.2022.113758info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T18:05:44Zoai:run.unl.pt:10362/144376Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:36:12.088295Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
HBM4EU chromates study usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure |
| title |
HBM4EU chromates study |
| spellingShingle |
HBM4EU chromates study Ndaw, Sophie Biological monitoring Electroplating Plasma chromium Red blood cells chromium Welding Workplace Biochemistry Environmental Science(all) SDG 3 - Good Health and Well-being |
| title_short |
HBM4EU chromates study |
| title_full |
HBM4EU chromates study |
| title_fullStr |
HBM4EU chromates study |
| title_full_unstemmed |
HBM4EU chromates study |
| title_sort |
HBM4EU chromates study |
| author |
Ndaw, Sophie |
| author_facet |
Ndaw, Sophie Leso, Veruscka Bousoumah, Radia Rémy, Aurélie Bocca, Beatrice Duca, Radu Corneliu Godderis, Lode Hardy, Emilie Janasik, Beata van Nieuwenhuyse, An Pinhal, Hermínia Poels, Katrien Porras, Simo P. Ruggieri, Flavia Santonen, Tiina Santos, Sílvia Reis Scheepers, Paul T.J. Silva, Maria João Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Iavicoli, Ivo |
| author_role |
author |
| author2 |
Leso, Veruscka Bousoumah, Radia Rémy, Aurélie Bocca, Beatrice Duca, Radu Corneliu Godderis, Lode Hardy, Emilie Janasik, Beata van Nieuwenhuyse, An Pinhal, Hermínia Poels, Katrien Porras, Simo P. Ruggieri, Flavia Santonen, Tiina Santos, Sílvia Reis Scheepers, Paul T.J. Silva, Maria João Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Iavicoli, Ivo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Comprehensive Health Research Centre (CHRC) - Pólo ENSP Escola Nacional de Saúde Pública (ENSP) Centro de Investigação em Saúde Pública (CISP/PHRC) RUN |
| dc.contributor.author.fl_str_mv |
Ndaw, Sophie Leso, Veruscka Bousoumah, Radia Rémy, Aurélie Bocca, Beatrice Duca, Radu Corneliu Godderis, Lode Hardy, Emilie Janasik, Beata van Nieuwenhuyse, An Pinhal, Hermínia Poels, Katrien Porras, Simo P. Ruggieri, Flavia Santonen, Tiina Santos, Sílvia Reis Scheepers, Paul T.J. Silva, Maria João Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Iavicoli, Ivo |
| dc.subject.por.fl_str_mv |
Biological monitoring Electroplating Plasma chromium Red blood cells chromium Welding Workplace Biochemistry Environmental Science(all) SDG 3 - Good Health and Well-being |
| topic |
Biological monitoring Electroplating Plasma chromium Red blood cells chromium Welding Workplace Biochemistry Environmental Science(all) SDG 3 - Good Health and Well-being |
| description |
Funding Information: This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Publisher Copyright: © 2022 The Authors |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-28T22:50:46Z 2022-11 2022-11-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/144376 |
| url |
http://hdl.handle.net/10362/144376 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0013-9351 PURE: 46786494 https://doi.org/10.1016/j.envres.2022.113758 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia |
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