Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Fernandez-Checa, Jose C; Bagnaninchi, Pierre; Ye, Hui; Sancho-Bru, Pau; Falcon-Perez, Juan M; Royo, Felix; Garcia-Ruiz, Carmen; Konu, Ozlen; Miranda, Joana; Lunov, Oleg; Dejneka, Alexandr; Elfick, Alistair; McDonald, Alison; Sullivan, Gareth J; Aithal, Guruprasad P; Lucena, M Isabel; Andrade, Raul J; Fromenty, Bernard; Kranendonk, Michel; Cubero, Francisco Javier; Nelson, Leonard J

Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

Bibliographic Details
Main Author:	Fernandez-Checa, Jose C
Publication Date:	2021
Other Authors:	Bagnaninchi, Pierre, Ye, Hui, Sancho-Bru, Pau, Falcon-Perez, Juan M, Royo, Felix, Garcia-Ruiz, Carmen, Konu, Ozlen, Miranda, Joana, Lunov, Oleg, Dejneka, Alexandr, Elfick, Alistair, McDonald, Alison, Sullivan, Gareth J, Aithal, Guruprasad P, Lucena, M Isabel, Andrade, Raul J, Fromenty, Bernard, Kranendonk, Michel, Cubero, Francisco Javier, Nelson, Leonard J
Format:	Other
Language:	eng
Source:	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
Download full:	http://hdl.handle.net/10362/125705
Summary:	Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Item metadata

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network_acronym_str	RCAP
network_name_str	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository_id_str	https://opendoar.ac.uk/repository/7160
spelling	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]SDG 3 - Good Health and Well-beingCopyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies. Although significant progress has been made in understanding the molecular mechanisms underlying DILI, our incomplete knowledge of its pathogenesis and inability to predict DILI is largely due to both discordance between human and animal DILI in preclinical drug development and a lack of models that faithfully recapitulate complex pathophysiological features of human DILI. This is exemplified by the hepatotoxicity of acetaminophen (APAP) overdose, a major cause of ALF because of its extensive worldwide use as an analgesic. Despite intensive efforts utilising current animal and in vitro models, the mechanisms involved in the hepatotoxicity of APAP are still not fully understood. In this expert Consensus Statement, which is endorsed by the European Drug-Induced Liver Injury Network, we aim to facilitate and outline clinically impactful discoveries by detailing the requirements for more realistic human-based systems to assess hepatotoxicity and guide future drug safety testing. We present novel insights and discuss major players in APAP pathophysiology, and describe emerging in vitro and in vivo pre-clinical models, as well as advanced imaging and in silico technologies, which may improve prediction of clinical outcomes of DILI.NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNFernandez-Checa, Jose CBagnaninchi, PierreYe, HuiSancho-Bru, PauFalcon-Perez, Juan MRoyo, FelixGarcia-Ruiz, CarmenKonu, OzlenMiranda, JoanaLunov, OlegDejneka, AlexandrElfick, AlistairMcDonald, AlisonSullivan, Gareth JAithal, Guruprasad PLucena, M IsabelAndrade, Raul JFromenty, BernardKranendonk, MichelCubero, Francisco JavierNelson, Leonard J2021-10-06T23:21:49Z2021-102021-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other25application/pdfhttp://hdl.handle.net/10362/125705eng0168-8278PURE: 34118353https://doi.org/10.1016/j.jhep.2021.06.021info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2024-05-22T17:56:32Zoai:run.unl.pt:10362/125705Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:27:40.234604Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse
dc.title.none.fl_str_mv	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
title	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
spellingShingle	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET] Fernandez-Checa, Jose C SDG 3 - Good Health and Well-being
title_short	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
title_full	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
title_fullStr	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
title_full_unstemmed	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
title_sort	Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
author	Fernandez-Checa, Jose C
author_facet	Fernandez-Checa, Jose C Bagnaninchi, Pierre Ye, Hui Sancho-Bru, Pau Falcon-Perez, Juan M Royo, Felix Garcia-Ruiz, Carmen Konu, Ozlen Miranda, Joana Lunov, Oleg Dejneka, Alexandr Elfick, Alistair McDonald, Alison Sullivan, Gareth J Aithal, Guruprasad P Lucena, M Isabel Andrade, Raul J Fromenty, Bernard Kranendonk, Michel Cubero, Francisco Javier Nelson, Leonard J
author_role	author
author2	Bagnaninchi, Pierre Ye, Hui Sancho-Bru, Pau Falcon-Perez, Juan M Royo, Felix Garcia-Ruiz, Carmen Konu, Ozlen Miranda, Joana Lunov, Oleg Dejneka, Alexandr Elfick, Alistair McDonald, Alison Sullivan, Gareth J Aithal, Guruprasad P Lucena, M Isabel Andrade, Raul J Fromenty, Bernard Kranendonk, Michel Cubero, Francisco Javier Nelson, Leonard J
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM) Centre for Toxicogenomics and Human Health (ToxOmics) RUN
dc.contributor.author.fl_str_mv	Fernandez-Checa, Jose C Bagnaninchi, Pierre Ye, Hui Sancho-Bru, Pau Falcon-Perez, Juan M Royo, Felix Garcia-Ruiz, Carmen Konu, Ozlen Miranda, Joana Lunov, Oleg Dejneka, Alexandr Elfick, Alistair McDonald, Alison Sullivan, Gareth J Aithal, Guruprasad P Lucena, M Isabel Andrade, Raul J Fromenty, Bernard Kranendonk, Michel Cubero, Francisco Javier Nelson, Leonard J
dc.subject.por.fl_str_mv	SDG 3 - Good Health and Well-being
topic	SDG 3 - Good Health and Well-being
description	Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
publishDate	2021
dc.date.none.fl_str_mv	2021-10-06T23:21:49Z 2021-10 2021-10-01T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/other
format	other
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10362/125705
url	http://hdl.handle.net/10362/125705
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	0168-8278 PURE: 34118353 https://doi.org/10.1016/j.jhep.2021.06.021
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	25 application/pdf
dc.source.none.fl_str_mv	reponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia instacron:RCAAP
instname_str	FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
collection	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)
repository.name.fl_str_mv	Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologia
repository.mail.fl_str_mv	info@rcaap.pt
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Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

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