Rotavirus A infection in pre- and post-vaccine period
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| Publication Date: | 2021 |
| Other Authors: | , , , , , , , , , , , , |
| Format: | Other |
| Language: | eng |
| Source: | Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) |
| Download full: | http://hdl.handle.net/10362/125035 |
Summary: | Publisher Copyright: © 2021 Chissaque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Rotavirus A infection in pre- and post-vaccine periodRisk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019)rotavirusvaccineInfectious DiseasesGeneticsPublic Health, Environmental and Occupational HealthBiochemistry, Genetics and Molecular Biology (miscellaneous)Immunology and Microbiology (miscellaneous)VirologyPediatrics, Perinatology, and Child HealthEpidemiologyHealth PolicySDG 1 - No PovertySDG 2 - Zero HungerSDG 3 - Good Health and Well-beingSDG 5 - Gender EqualitySDG 6 - Clean Water and SanitationSDG 10 - Reduced InequalitiesSDG 11 - Sustainable Cities and CommunitiesSDG 16 - Peace, Justice and Strong InstitutionsSDG 17 - Partnerships for the GoalsPublisher Copyright: © 2021 Chissaque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Mozambique introduced the monovalent rotavirus vaccine (Rotarix®, GSK Biologicals, Rixensart, Belgium) in September 2015. Previous analysis, showed that Nampula province continues reporting a high frequency of Rotavirus A (RVA) infection and the emergence of G9P[6], G9P[4] and G3P[4] genotypes. This analysis aimed to determine the RVA frequency; risk factors; genotype distribution by vaccination status and age between pre- and post-vaccine periods in children under-five years old with diarrhea in Nampula. A cross-sectional, hospital-based surveillance study was conducted in the Hospital Central de Nampula in Mozambique. Socio-demographic and clinical data were collected to assess factors related to RVA infection in both periods. Stool specimens were screened to detect RVA by ELISA, and positive samples were genotyped. Between 2015 (pre-vaccine period) and 2016-2019 (post-vaccine period), 614 stool specimens were collected and tested for RVA in which 34.9% (67/192) were positive in pre-vaccine period and 21.8% (92/422) in post-vaccine (p = 0.001). In the post-vaccine period, age, year, and contact with different animal species (chicken, duck, or multiple animals) were associated with RVA infection. RVA infection was higher in children partially vaccinated (40.7%, 11/27) followed by the fully vaccinated (29.3%, 56/191) and the unvaccinated (15.3%, 21/137) (p = 0.002). G1P[8] and G9P[4] were common in vaccinated children less than 12 months. The present analysis showed that RVA infection reduced slightly in the post-vaccine period, with a high proportion of infection and genotype diversity in children, under 12 months of age, vaccinated. Further research on factors associated with RVA infection on vaccinated compared to unvaccinated children and vaccination optimization should be done.Instituto de Higiene e Medicina Tropical (IHMT)Population health, policies and services (PPS)Global Health and Tropical Medicine (GHTM)RUNChissaque, AssucênioBauhofer, Adilson Fernando LoforteCossa-Moiane, IdaleciaSitoe, EzequiasMunlela, BenildeJoão, Eva DoraLanga, Jeronimo S.Chilaule, Jorfelia JoseBoene, Simone SalvadorCassocera, MartaLourenço Guimarães, EsperançaKellogg, Timothy A.Goncalves, LuziaDe Deus, Nilsa2021-09-23T01:07:29Z2021-08-062021-08-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other17application/pdfhttp://hdl.handle.net/10362/125035eng1932-6203PURE: 33791137https://doi.org/10.1371/journal.pone.0255720info:eu-repo/semantics/openAccessreponame:Repositórios Científicos de Acesso Aberto de Portugal (RCAAP)instname:FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiainstacron:RCAAP2025-04-14T01:36:42Zoai:run.unl.pt:10362/125035Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireinfo@rcaap.ptopendoar:https://opendoar.ac.uk/repository/71602025-05-28T17:27:32.556098Repositórios Científicos de Acesso Aberto de Portugal (RCAAP) - FCCN, serviços digitais da FCT – Fundação para a Ciência e a Tecnologiafalse |
| dc.title.none.fl_str_mv |
Rotavirus A infection in pre- and post-vaccine period Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019) |
| title |
Rotavirus A infection in pre- and post-vaccine period |
| spellingShingle |
Rotavirus A infection in pre- and post-vaccine period Chissaque, Assucênio rotavirus vaccine Infectious Diseases Genetics Public Health, Environmental and Occupational Health Biochemistry, Genetics and Molecular Biology (miscellaneous) Immunology and Microbiology (miscellaneous) Virology Pediatrics, Perinatology, and Child Health Epidemiology Health Policy SDG 1 - No Poverty SDG 2 - Zero Hunger SDG 3 - Good Health and Well-being SDG 5 - Gender Equality SDG 6 - Clean Water and Sanitation SDG 10 - Reduced Inequalities SDG 11 - Sustainable Cities and Communities SDG 16 - Peace, Justice and Strong Institutions SDG 17 - Partnerships for the Goals |
| title_short |
Rotavirus A infection in pre- and post-vaccine period |
| title_full |
Rotavirus A infection in pre- and post-vaccine period |
| title_fullStr |
Rotavirus A infection in pre- and post-vaccine period |
| title_full_unstemmed |
Rotavirus A infection in pre- and post-vaccine period |
| title_sort |
Rotavirus A infection in pre- and post-vaccine period |
| author |
Chissaque, Assucênio |
| author_facet |
Chissaque, Assucênio Bauhofer, Adilson Fernando Loforte Cossa-Moiane, Idalecia Sitoe, Ezequias Munlela, Benilde João, Eva Dora Langa, Jeronimo S. Chilaule, Jorfelia Jose Boene, Simone Salvador Cassocera, Marta Lourenço Guimarães, Esperança Kellogg, Timothy A. Goncalves, Luzia De Deus, Nilsa |
| author_role |
author |
| author2 |
Bauhofer, Adilson Fernando Loforte Cossa-Moiane, Idalecia Sitoe, Ezequias Munlela, Benilde João, Eva Dora Langa, Jeronimo S. Chilaule, Jorfelia Jose Boene, Simone Salvador Cassocera, Marta Lourenço Guimarães, Esperança Kellogg, Timothy A. Goncalves, Luzia De Deus, Nilsa |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Population health, policies and services (PPS) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Chissaque, Assucênio Bauhofer, Adilson Fernando Loforte Cossa-Moiane, Idalecia Sitoe, Ezequias Munlela, Benilde João, Eva Dora Langa, Jeronimo S. Chilaule, Jorfelia Jose Boene, Simone Salvador Cassocera, Marta Lourenço Guimarães, Esperança Kellogg, Timothy A. Goncalves, Luzia De Deus, Nilsa |
| dc.subject.por.fl_str_mv |
rotavirus vaccine Infectious Diseases Genetics Public Health, Environmental and Occupational Health Biochemistry, Genetics and Molecular Biology (miscellaneous) Immunology and Microbiology (miscellaneous) Virology Pediatrics, Perinatology, and Child Health Epidemiology Health Policy SDG 1 - No Poverty SDG 2 - Zero Hunger SDG 3 - Good Health and Well-being SDG 5 - Gender Equality SDG 6 - Clean Water and Sanitation SDG 10 - Reduced Inequalities SDG 11 - Sustainable Cities and Communities SDG 16 - Peace, Justice and Strong Institutions SDG 17 - Partnerships for the Goals |
| topic |
rotavirus vaccine Infectious Diseases Genetics Public Health, Environmental and Occupational Health Biochemistry, Genetics and Molecular Biology (miscellaneous) Immunology and Microbiology (miscellaneous) Virology Pediatrics, Perinatology, and Child Health Epidemiology Health Policy SDG 1 - No Poverty SDG 2 - Zero Hunger SDG 3 - Good Health and Well-being SDG 5 - Gender Equality SDG 6 - Clean Water and Sanitation SDG 10 - Reduced Inequalities SDG 11 - Sustainable Cities and Communities SDG 16 - Peace, Justice and Strong Institutions SDG 17 - Partnerships for the Goals |
| description |
Publisher Copyright: © 2021 Chissaque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| publishDate |
2021 |
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2021-09-23T01:07:29Z 2021-08-06 2021-08-06T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/other |
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http://hdl.handle.net/10362/125035 |
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eng |
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eng |
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1932-6203 PURE: 33791137 https://doi.org/10.1371/journal.pone.0255720 |
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