Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites

Bibliographic Details
Main Author: Luz, Nívea Farias
Publication Date: 2018
Other Authors: Vieira, Thiago de Souza, Castro, Waldione de, Vivarini, Aislan de Carvalho, Pereira, Lais, França, Riam Rocha, Mattos, Paulo Sérgio de Morais da Silveira, Costa, Diego Luis, Teixeira, Clarissa, Meneses, Claudio, Boaventura, Viviane Sampaio, Oliveira, Camila Indiani de, Lopes, Ulisses Gazos, Aronson, Naomi, Andrade, Bruno de Bezerril, Brodskyn, Claudia Ida, Valenzuela, Jesus G., Kamhawi, Shaden, Borges, Valeria de Matos
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3389/fimmu.2018.02779
Download full: https://arca.fiocruz.br/handle/icict/30695
Summary: Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq.
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spelling Luz, Nívea FariasVieira, Thiago de SouzaCastro, Waldione deVivarini, Aislan de CarvalhoPereira, LaisFrança, Riam RochaMattos, Paulo Sérgio de Morais da SilveiraCosta, Diego LuisTeixeira, ClarissaMeneses, ClaudioBoaventura, Viviane SampaioOliveira, Camila Indiani deLopes, Ulisses GazosAronson, NaomiAndrade, Bruno de BezerrilBrodskyn, Claudia IdaValenzuela, Jesus G.Kamhawi, ShadenBorges, Valeria de Matos2018-12-19T16:46:42Z2018-12-19T16:46:42Z2018LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018.1664-3224https://arca.fiocruz.br/handle/icict/3069510.3389/fimmu.2018.02779Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, United States.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Federal University of Rio de Janeiro. Carlos Chagas Filho Biophysics Institute. Laboratory of Molecular Parasitology, Center of Health Science. Rio de Janeiro, RJ, Brazil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases, Immunobiology Section. Bethesda, MD, USA.Fundação Oswaldo Cruz. Teresina, PI, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Federal University of Rio de Janeiro. Carlos Chagas Filho Biophysics Institute. Laboratory of Molecular Parasitology, Center of Health Science. Rio de Janeiro, RJ, Brazil.Uniformed Services University of the Health Sciences. Infectious Diseases Division. Bethesda, MD, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Fundação José Silveira, Bahia. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, USA.National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Section. Rockville, MD, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Sand flies bite mammalian hosts to obtain a blood meal, driving changes in the host inflammatory response that support the establishment of Leishmania infection. This effect is partially attributed to components of sand fly saliva, which are able to recruit and activate leukocytes. Our group has shown that heme oxygenase-1 (HO-1) favors Leishmania survival in infected cells by reducing inflammatory responses. Here, we show that exposure to sand fly bites is associated with induction of HO-1 in vivo. Histopathological analyses of skin specimens from human volunteers experimentally exposed to sand fly bites revealed that HO-1 and Nrf2 are produced at bite sites in the skin. These results were recapitulated in mice ears injected with a salivary gland sonicate (SGS) or exposed to sand fly bites, indicating that vector saliva may be a key factor in triggering HO-1 expression. Resident skin macrophages were the main source HO-1 at 24-48 h after bites. Additionally, assays in vivo after bites and in vitro after stimulation with saliva both demonstrated that HO-1 production by macrophages was Nrf2-dependent. Collectively, our data demonstrates that vector saliva induces early HO-1 production at the bite sites, representing a major event associated with establishment of naturally-transmitted Leishmania infections.engFrontiers MediaLutzomyia longipalpisMosca da areiaSalivaPeleMacrófagosHeme oxigenase-1Nrf2Lutzomyia longipalpisSand fly biteSalivaSkinMacrophagesHeme oxygenase-1Nrf2Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/b66d86ce-d24e-4c45-8e46-ac3320f8f6c0/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALLuz NF. Lutzomyia longipalpis saliva...2018.pdfLuz NF. 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dc.title.none.fl_str_mv Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
title Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
spellingShingle Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
Luz, Nívea Farias
Lutzomyia longipalpis
Mosca da areia
Saliva
Pele
Macrófagos
Heme oxigenase-1
Nrf2
Lutzomyia longipalpis
Sand fly bite
Saliva
Skin
Macrophages
Heme oxygenase-1
Nrf2
title_short Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
title_full Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
title_fullStr Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
title_full_unstemmed Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
title_sort Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites
author Luz, Nívea Farias
author_facet Luz, Nívea Farias
Vieira, Thiago de Souza
Castro, Waldione de
Vivarini, Aislan de Carvalho
Pereira, Lais
França, Riam Rocha
Mattos, Paulo Sérgio de Morais da Silveira
Costa, Diego Luis
Teixeira, Clarissa
Meneses, Claudio
Boaventura, Viviane Sampaio
Oliveira, Camila Indiani de
Lopes, Ulisses Gazos
Aronson, Naomi
Andrade, Bruno de Bezerril
Brodskyn, Claudia Ida
Valenzuela, Jesus G.
Kamhawi, Shaden
Borges, Valeria de Matos
author_role author
author2 Vieira, Thiago de Souza
Castro, Waldione de
Vivarini, Aislan de Carvalho
Pereira, Lais
França, Riam Rocha
Mattos, Paulo Sérgio de Morais da Silveira
Costa, Diego Luis
Teixeira, Clarissa
Meneses, Claudio
Boaventura, Viviane Sampaio
Oliveira, Camila Indiani de
Lopes, Ulisses Gazos
Aronson, Naomi
Andrade, Bruno de Bezerril
Brodskyn, Claudia Ida
Valenzuela, Jesus G.
Kamhawi, Shaden
Borges, Valeria de Matos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luz, Nívea Farias
Vieira, Thiago de Souza
Castro, Waldione de
Vivarini, Aislan de Carvalho
Pereira, Lais
França, Riam Rocha
Mattos, Paulo Sérgio de Morais da Silveira
Costa, Diego Luis
Teixeira, Clarissa
Meneses, Claudio
Boaventura, Viviane Sampaio
Oliveira, Camila Indiani de
Lopes, Ulisses Gazos
Aronson, Naomi
Andrade, Bruno de Bezerril
Brodskyn, Claudia Ida
Valenzuela, Jesus G.
Kamhawi, Shaden
Borges, Valeria de Matos
dc.subject.other.none.fl_str_mv Lutzomyia longipalpis
Mosca da areia
Saliva
Pele
Macrófagos
Heme oxigenase-1
Nrf2
topic Lutzomyia longipalpis
Mosca da areia
Saliva
Pele
Macrófagos
Heme oxigenase-1
Nrf2
Lutzomyia longipalpis
Sand fly bite
Saliva
Skin
Macrophages
Heme oxygenase-1
Nrf2
dc.subject.en.none.fl_str_mv Lutzomyia longipalpis
Sand fly bite
Saliva
Skin
Macrophages
Heme oxygenase-1
Nrf2
description Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. NL is a fellowship recipient from CAPES Brazil; PM is a fellowship recipient from FAPESB; AV is a fellowship recipient from Programa Nacional de Pós-Doutorado/CAPES; CdO, UL, CB and VMB are senior investigators of CNPq.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-19T16:46:42Z
dc.date.available.fl_str_mv 2018-12-19T16:46:42Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/30695
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2018.02779
identifier_str_mv LUZ, Nívea Farias et al. Lutzomyia longipalpis saliva induces heme oxygenase-1 expression at bite sites. Frontiers in Immunology, v. 9, p. 1-10, Nov. 2018.
1664-3224
10.3389/fimmu.2018.02779
url https://arca.fiocruz.br/handle/icict/30695
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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