Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice

Bibliographic Details
Main Author: Rocha, Viviane Costa Junqueira
Publication Date: 2016
Other Authors: França, Luciana Souza de Aragão, Araújo, Cintia Figueiredo de, Ng, Ayling Martins, Andrade, Candace Machado de, Andrade, André Cronemberger, Santos, Emanuelle de Souza, Silva, Mariana da Cruz Borges, Macambira, Simone Garcia, Noronha-Dutra, Alberto Augusto, Pontes-De-Carvalho, Lain Carlos
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1007/s00280-015-2949-7
Download full: https://arca.fiocruz.br/handle/icict/15196
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Rocha, Viviane Costa JunqueiraFrança, Luciana Souza de AragãoAraújo, Cintia Figueiredo deNg, Ayling MartinsAndrade, Candace Machado deAndrade, André CronembergerSantos, Emanuelle de SouzaSilva, Mariana da Cruz BorgesMacambira, Simone GarciaNoronha-Dutra, Alberto AugustoPontes-De-Carvalho, Lain Carlos2016-08-04T17:19:15Z2016-08-04T17:19:15Z2016ROCHA, V. C. J. et al. Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice. Cancer Chemotherapy and Pharmacology, v. 77, p. 659–662, 2016.0344-5704https://arca.fiocruz.br/handle/icict/1519610.1007/s00280-015-2949-7engSpringer VerlagProtective effects of mito-TEMPO against doxorubicin cardiotoxicity in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de São Paulo. Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / University College London. Gower Street, London, UKFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilDoxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice. Methods C57BL/6 mice were treated twice with mito- T at low (5 mg/kg body weight) or high (20 mg/kg body weight) dose and once with DOX (24 mg/kg body weight) or saline (0.1 mL/20 g body weight) by means of intraperitoneal injections. The levels of malondialdehyde (MLDA), a marker of lipid peroxidation, and serum levels of creatine kinase were evaluated 48 h after the injection of DOX. Results DOX induced lipid peroxidation in heart mitochondria (p < 0.001), and DOX-treated mice receiving mito-T at low dose had levels of MLDA significantly lower than the mice that received only DOX (p < 0.01). Furthermore, administration of mito-T alone did not cause any significant changes from control values. Additionally, DOX-treated mice treated with mito-T at high dose showed decrease in serum levels of total CK compared to mice treated with DOX alone (p < 0.05). Conclusion Our results indicate that mito-T protects mice against DOX-induced cardiotoxicity.DoxorubicinCardiotoxicityMitochondriaMito-TEMPOCreatine kinaseLipid peroxidationCardiotonic agentsAntibioticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/e94b0434-657b-4e05-bd62-2d751856558e/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALRocha VCJ Protective effects....pdfRocha VCJ Protective effects....pdfapplication/pdf461299https://arca.fiocruz.br/bitstreams/b5385403-ed8c-4f34-9c58-3e1cb9f759e1/download28698848bfac2a7a79258dd3f9621fb2MD52trueAnonymousREADTEXTRocha VCJ Protective effects....pdf.txtRocha VCJ Protective effects....pdf.txtExtracted texttext/plain16962https://arca.fiocruz.br/bitstreams/7957bf24-d9c2-4467-8ddc-584f1968d09a/download51f41e9020bb8e520199ef80d865624eMD55falseAnonymousREADTHUMBNAILRocha VCJ Protective effects....pdf.jpgRocha VCJ Protective effects....pdf.jpgGenerated Thumbnailimage/jpeg5857https://arca.fiocruz.br/bitstreams/d17dfe97-4108-40f2-8187-090b39a46ab3/download5ae0c6500638580e84a3edd18641ce37MD56falseAnonymousREADicict/151962025-07-30 00:55:12.663open.accessoai:arca.fiocruz.br:icict/15196https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T03:55:12Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
title Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
spellingShingle Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
Rocha, Viviane Costa Junqueira
Doxorubicin
Cardiotoxicity
Mitochondria
Mito-TEMPO
Creatine kinase
Lipid peroxidation
Cardiotonic agents
Antibiotics
title_short Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
title_full Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
title_fullStr Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
title_full_unstemmed Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
title_sort Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice
author Rocha, Viviane Costa Junqueira
author_facet Rocha, Viviane Costa Junqueira
França, Luciana Souza de Aragão
Araújo, Cintia Figueiredo de
Ng, Ayling Martins
Andrade, Candace Machado de
Andrade, André Cronemberger
Santos, Emanuelle de Souza
Silva, Mariana da Cruz Borges
Macambira, Simone Garcia
Noronha-Dutra, Alberto Augusto
Pontes-De-Carvalho, Lain Carlos
author_role author
author2 França, Luciana Souza de Aragão
Araújo, Cintia Figueiredo de
Ng, Ayling Martins
Andrade, Candace Machado de
Andrade, André Cronemberger
Santos, Emanuelle de Souza
Silva, Mariana da Cruz Borges
Macambira, Simone Garcia
Noronha-Dutra, Alberto Augusto
Pontes-De-Carvalho, Lain Carlos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Viviane Costa Junqueira
França, Luciana Souza de Aragão
Araújo, Cintia Figueiredo de
Ng, Ayling Martins
Andrade, Candace Machado de
Andrade, André Cronemberger
Santos, Emanuelle de Souza
Silva, Mariana da Cruz Borges
Macambira, Simone Garcia
Noronha-Dutra, Alberto Augusto
Pontes-De-Carvalho, Lain Carlos
dc.subject.en.none.fl_str_mv Doxorubicin
Cardiotoxicity
Mitochondria
Mito-TEMPO
Creatine kinase
Lipid peroxidation
Cardiotonic agents
Antibiotics
topic Doxorubicin
Cardiotoxicity
Mitochondria
Mito-TEMPO
Creatine kinase
Lipid peroxidation
Cardiotonic agents
Antibiotics
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-08-04T17:19:15Z
dc.date.available.fl_str_mv 2016-08-04T17:19:15Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, V. C. J. et al. Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice. Cancer Chemotherapy and Pharmacology, v. 77, p. 659–662, 2016.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/15196
dc.identifier.issn.none.fl_str_mv 0344-5704
dc.identifier.doi.none.fl_str_mv 10.1007/s00280-015-2949-7
identifier_str_mv ROCHA, V. C. J. et al. Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice. Cancer Chemotherapy and Pharmacology, v. 77, p. 659–662, 2016.
0344-5704
10.1007/s00280-015-2949-7
url https://arca.fiocruz.br/handle/icict/15196
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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