Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis

Detalhes bibliográficos
Autor(a) principal: Pereira, Isabela T.
Data de Publicação: 2024
Outros Autores: Gomes-Júnior, Rubens, Hansel-Frose, Aruana, França, Rhaíza S. V., Liu, Man, Soliman, Hossam A. N., Chan, Sunny S. K., Dudley, Samuel C. Jr, Kyba, Michael, Dallagiovanna, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3390/cells13121050
Texto Completo: https://arca.fiocruz.br/handle/icict/67641
Resumo: Data Availability Statement: RNA-Seq data generated in this study have been deposited in the NCBI Sequence Read Archive under accession number PRJNA926378 and are publicly available as of the date of publication. RNA-seq data of in vitro cardiac differentiation was previously generated by our group [17] and is available at NCBI Sequence Read Archive, accession number SRP150416. RNA-seq data heart tissues were acquired from European Nucleotide Archive (ENA) (http://www.ebi.ac.uk/ena, accessed on 25 May 2022). Accession numbers for adult heart tissue data: ERR315356, ERR315430, ERR315367 and ERR315331. Project number for fetal heart tissue data: PRJEB27811 [18].
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spelling Pereira, Isabela T.Gomes-Júnior, RubensHansel-Frose, AruanaFrança, Rhaíza S. V.Liu, ManSoliman, Hossam A. N.Chan, Sunny S. K.Dudley, Samuel C. JrKyba, MichaelDallagiovanna, Bruno2024-12-17T10:37:11Z2024-12-17T10:37:11Z2024PEREIRA, I. T. et al. Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis. Cells, v. 13, n. 1050, p. 1-17, 2024.2012-9999https://arca.fiocruz.br/handle/icict/6764110.3390/cells13121050Data Availability Statement: RNA-Seq data generated in this study have been deposited in the NCBI Sequence Read Archive under accession number PRJNA926378 and are publicly available as of the date of publication. RNA-seq data of in vitro cardiac differentiation was previously generated by our group [17] and is available at NCBI Sequence Read Archive, accession number SRP150416. RNA-seq data heart tissues were acquired from European Nucleotide Archive (ENA) (http://www.ebi.ac.uk/ena, accessed on 25 May 2022). Accession numbers for adult heart tissue data: ERR315356, ERR315430, ERR315367 and ERR315331. Project number for fetal heart tissue data: PRJEB27811 [18].This work was supported by CNPq: National Center of Science and Technology for Regenerative Medicine/REGENERA grant 465656/2014-5, CNPq PROEP/ICC grant 442353/2019-7, CAPES grant INCT-REGENERA 88887.136364/2017-00, and NIH grants 1R56HL162208 and R01-HL134791. I.T.P., R.G. and A.H. received fellowships from CAPES and B.D. from CNPq.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil.University of Minnesota. Department of Medicine. Division of Cardiology. Minneapolis, USA / University of Minnesota. Lillehei Heart Institute. Minneapolis, USA.University of Minnesota. Lillehei Heart Institute. Minneapolis, USA / University of Minnesota. Department of Pediatrics. Minneapolis, USA.University of Minnesota. Lillehei Heart Institute. Minneapolis, USA / University of Minnesota. Department of Pediatrics. Minneapolis, USA / University of Minnesota. Stem Cell Institute. Minneapolis, USA.University of Minnesota. Department of Medicine. Division of Cardiology. Minneapolis, USA / University of Minnesota. Lillehei Heart Institute. Minneapolis, USA.University of Minnesota. Lillehei Heart Institute. Minneapolis, USA / University of Minnesota. Department of Pediatrics. Minneapolis, USA.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células-tronco. Curitiba, PR, Brasil.Successful heart development depends on the careful orchestration of a network of transcription factors and signaling pathways. In recent years, in vitro cardiac differentiation using human pluripotent stem cells (hPSCs) has been used to uncover the intricate gene-network regulation involved in the proper formation and function of the human heart. Here, we searched for uncharacterized cardiac-development genes by combining a temporal evaluation of human cardiac specification in vitro with an analysis of gene expression in fetal and adult heart tissue. We discovered that CARDEL (CARdiac DEvelopment Long non-coding RNA; LINC00890; SERTM2) expression coincides with the commitment to the cardiac lineage. CARDEL knockout hPSCs differentiated poorly into cardiac cells, and hPSC-derived cardiomyocytes showed faster beating rates after controlled overexpression of CARDEL during differentiation. Altogether, we provide physiological and molecular evidence that CARDEL expression contributes to sculpting the cardiac program during cell-fate commitment.engMDPICardiomiócitosExpressão gênicaDesenvolvimento cardíacoCardiomyocyteslncRNAGene expressionCardiac developmentHomeostaseRNA Longo não CodificanteCoraçãoCardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/5e6b3694-993e-4999-994e-a8d432e2c588/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALve_Isabela_Pereira_etal_ICC_2024.pdfve_Isabela_Pereira_etal_ICC_2024.pdfapplication/pdf2058730https://arca.fiocruz.br/bitstreams/b1a07ccf-c12d-459c-bb97-f0be236d0760/download506ca2a412747b4fcdab26af560e4c07MD52trueAnonymousREADTEXTve_Isabela_Pereira_etal_ICC_2024.pdf.txtve_Isabela_Pereira_etal_ICC_2024.pdf.txtExtracted texttext/plain73707https://arca.fiocruz.br/bitstreams/06e5e97f-44cf-4339-b2c2-fb285899da66/download4d07882ba532606a20e9b6bc80ae381fMD55falseAnonymousREADTHUMBNAILve_Isabela_Pereira_etal_ICC_2024.pdf.jpgve_Isabela_Pereira_etal_ICC_2024.pdf.jpgGenerated Thumbnailimage/jpeg5890https://arca.fiocruz.br/bitstreams/12cc783f-fe64-4d95-8d2e-a9b850ccf493/download8b58d94f5a831c2efaad1274aff84f4aMD56falseAnonymousREADicict/676412025-07-29 20:48:18.703open.accessoai:arca.fiocruz.br:icict/67641https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T23:48:18Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
title Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
spellingShingle Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
Pereira, Isabela T.
Cardiomiócitos
Expressão gênica
Desenvolvimento cardíaco
Cardiomyocytes
lncRNA
Gene expression
Cardiac development
Homeostase
RNA Longo não Codificante
Coração
title_short Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
title_full Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
title_fullStr Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
title_full_unstemmed Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
title_sort Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis
author Pereira, Isabela T.
author_facet Pereira, Isabela T.
Gomes-Júnior, Rubens
Hansel-Frose, Aruana
França, Rhaíza S. V.
Liu, Man
Soliman, Hossam A. N.
Chan, Sunny S. K.
Dudley, Samuel C. Jr
Kyba, Michael
Dallagiovanna, Bruno
author_role author
author2 Gomes-Júnior, Rubens
Hansel-Frose, Aruana
França, Rhaíza S. V.
Liu, Man
Soliman, Hossam A. N.
Chan, Sunny S. K.
Dudley, Samuel C. Jr
Kyba, Michael
Dallagiovanna, Bruno
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Isabela T.
Gomes-Júnior, Rubens
Hansel-Frose, Aruana
França, Rhaíza S. V.
Liu, Man
Soliman, Hossam A. N.
Chan, Sunny S. K.
Dudley, Samuel C. Jr
Kyba, Michael
Dallagiovanna, Bruno
dc.subject.other.none.fl_str_mv Cardiomiócitos
Expressão gênica
Desenvolvimento cardíaco
topic Cardiomiócitos
Expressão gênica
Desenvolvimento cardíaco
Cardiomyocytes
lncRNA
Gene expression
Cardiac development
Homeostase
RNA Longo não Codificante
Coração
dc.subject.en.none.fl_str_mv Cardiomyocytes
lncRNA
Gene expression
Cardiac development
dc.subject.decs.none.fl_str_mv Homeostase
RNA Longo não Codificante
Coração
description Data Availability Statement: RNA-Seq data generated in this study have been deposited in the NCBI Sequence Read Archive under accession number PRJNA926378 and are publicly available as of the date of publication. RNA-seq data of in vitro cardiac differentiation was previously generated by our group [17] and is available at NCBI Sequence Read Archive, accession number SRP150416. RNA-seq data heart tissues were acquired from European Nucleotide Archive (ENA) (http://www.ebi.ac.uk/ena, accessed on 25 May 2022). Accession numbers for adult heart tissue data: ERR315356, ERR315430, ERR315367 and ERR315331. Project number for fetal heart tissue data: PRJEB27811 [18].
publishDate 2024
dc.date.accessioned.fl_str_mv 2024-12-17T10:37:11Z
dc.date.available.fl_str_mv 2024-12-17T10:37:11Z
dc.date.issued.fl_str_mv 2024
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv PEREIRA, I. T. et al. Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis. Cells, v. 13, n. 1050, p. 1-17, 2024.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/67641
dc.identifier.issn.none.fl_str_mv 2012-9999
dc.identifier.doi.none.fl_str_mv 10.3390/cells13121050
identifier_str_mv PEREIRA, I. T. et al. Cardiac development long non-coding RNA (CARDEL) is activated during human heart development and contributes to cardiac specification and homeostasis. Cells, v. 13, n. 1050, p. 1-17, 2024.
2012-9999
10.3390/cells13121050
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