SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://arca.fiocruz.br/handle/icict/65767 |
Resumo: | 55º Congresso da Sociedade Brasileira de Medicina Tropical ◦ XXVI Congresso da Sociedade Brasileira de Parasitologia CHAGASLEISH 2019. Trabalho aparesentado no MEDTROP-Parasito 2019, realizado em Belo Horizonte no período de 28 a 31 de julho de 2019. |
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Paula, Naiara Cristina Clemente dos Santos Tavares deMoreira, Bernardo PereiraArmstrong, TomPaiva, Clara Ênia deTorres, Gabriella ParreirasOliveira, Guilherme Corrêa deGava, Sandra GrossiFalconi, Franco HaraldMourão, Marina Moraes2024-09-05T12:26:06Z2024-09-05T12:26:06Z2019PAULA, Naiara Cristina Clemente dos Santos Tavares de et al. SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction. In: MEDTROP: PARASITO: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 55., 2019; CONGRESSO DA SOCIEDADE BRASILEIRA DE PARASITOLOGIA CHAGASLEISH, 26., 2019. Belo Horizonte. Anais... Belo Horizonte: SBMT, 2019. p. 106-107.https://arca.fiocruz.br/handle/icict/6576755º Congresso da Sociedade Brasileira de Medicina Tropical ◦ XXVI Congresso da Sociedade Brasileira de Parasitologia CHAGASLEISH 2019. Trabalho aparesentado no MEDTROP-Parasito 2019, realizado em Belo Horizonte no período de 28 a 31 de julho de 2019.Supported by: CAPES Finance Code 001 and CAPES/University of Nottingham- Drug Discovery Program 003/2014; and CNPq grant: 302518/2018-5. FIOCRUZFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.University Nottingham, UK.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Instituto Tecnológico Vale, Belém, PA, Brasil.University Nottingham, UK.University Nottingham, UK.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Protein kinases (PKs) have central role in extracellular signals mediation. Accordingly, PKs are considered important to Schistosoma mansoni homeostasis maintenance and cellular adaptations since this parasite relies in specific environmental signals to induce responses through sensorial receptors and intracellular proteins. However, the role of these proteins in S. mansoni biology is not well known. This work aims at characterizing the functions of SmFES and SmRAF protein kinases using RNA interference (RNAi) and compounds screening to identifying specific inhibitors. Thus, schistosomula and adult worms were subjected to SmFES and SmRAF knockdown by RNAi. SmFES and SmRAF transcript levels in schistosomula and adult worms were 60%-80% reduced. SmFES knocked-down schistosomula presented significant size reduction (~10%) and 28% of mortality when compared to unspecific control group (GFP). Mice infected with SmRAF knocked-down schistosomula showed a significant decrease in adult worms (27%) and eggs (46%) recovered from the intestine, compared to GFP. Besides, the final section from the small intestine of mice infected with SmFES and SmRAF knocked-down schistosomula presented ~25% more immature eggs than the unspecific control group and histological analyses are underway. Additionally, SmFES and SmRAF protein structures and ATB-binding sites were predicted using Phyre2 software. In silico docking analysis were performed with 80,000 compounds from University of Nottingham MCCC Library. Compounds with predicted affinity with SmFES and SmRAF ATP-binding sites were selected using ChemPLP Score in order to perform an in vitro viability screening in schistosomula and adult worms. These preliminary results demonstrate that SmRAF seems to play a role in S. mansoni development and reproduction during the infection of mammalian host. SmFES seems to be essential to S. mansoni reproduction, egg maturation and schistosomula survival and development in vitro.porSBMTProteínas SmFESProteínas SmRAFSchistosoma mansoniMEDTROP-ParasitoAnaisCongressoSmRAF protein kinasesSmFES protein kinasesSchistosoma mansoniCongressProteínas QuinasesEsquistossomose mansoniCongressoSmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproductioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/f5a2e6ec-2e25-4092-8e04-bb19d4afb6fa/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALSmFES and SmRAF protein kinases.pdfSmFES and SmRAF protein kinases.pdfapplication/pdf122062https://arca.fiocruz.br/bitstreams/e5c70795-1511-443e-9a18-39529036419a/download1cc4d4a44b9d0b97f538cbfdde9235a1MD52trueAnonymousREAD_MEDTROP_2019.jpg_MEDTROP_2019.jpgimage/jpeg33223https://arca.fiocruz.br/bitstreams/bcd93194-0310-46d6-acf7-e035de46cf9a/download8ae701f8fdd9136f6024b11f02e39fd1MD53falseAnonymousREADTHUMBNAIL_MEDTROP_2019.jpg_MEDTROP_2019.jpgimage/jpeg33223https://arca.fiocruz.br/bitstreams/00303b6d-bfae-4de7-a49b-977feedc43dd/download8ae701f8fdd9136f6024b11f02e39fd1MD54falseAnonymousREADSmFES and SmRAF protein kinases.pdf.jpgSmFES and SmRAF protein kinases.pdf.jpgGenerated Thumbnailimage/jpeg5929https://arca.fiocruz.br/bitstreams/6ad4fcf7-02ed-45b9-8ebe-da54c01490a7/download8896a68ea11040f0cb3501c9571de1a5MD59falseAnonymousREAD_MEDTROP_2019.jpg.jpg_MEDTROP_2019.jpg.jpgGenerated Thumbnailimage/jpeg7437https://arca.fiocruz.br/bitstreams/b7d027d0-9544-4f19-bcdb-3ae888d22ad8/download1268899e1335ee94e0897c9ddf0fd66dMD510falseAnonymousREADTEXTSmFES and SmRAF protein kinases.pdf.txtSmFES and SmRAF protein kinases.pdf.txtExtracted texttext/plain9002https://arca.fiocruz.br/bitstreams/e50c16b6-27d5-4352-8dcf-f373e01a4619/download195d649f82d0ea07277f59a5d9bdd45aMD58falseAnonymousREADicict/657672025-07-29 22:06:33.253open.accessoai:arca.fiocruz.br:icict/65767https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T01:06:33Repositório Institucional da FIOCRUZ (ARCA) - 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SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| title |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| spellingShingle |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction Paula, Naiara Cristina Clemente dos Santos Tavares de Proteínas SmFES Proteínas SmRAF Schistosoma mansoni MEDTROP-Parasito Anais Congresso SmRAF protein kinases SmFES protein kinases Schistosoma mansoni Congress Proteínas Quinases Esquistossomose mansoni Congresso |
| title_short |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| title_full |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| title_fullStr |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| title_full_unstemmed |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| title_sort |
SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction |
| author |
Paula, Naiara Cristina Clemente dos Santos Tavares de |
| author_facet |
Paula, Naiara Cristina Clemente dos Santos Tavares de Moreira, Bernardo Pereira Armstrong, Tom Paiva, Clara Ênia de Torres, Gabriella Parreiras Oliveira, Guilherme Corrêa de Gava, Sandra Grossi Falconi, Franco Harald Mourão, Marina Moraes |
| author_role |
author |
| author2 |
Moreira, Bernardo Pereira Armstrong, Tom Paiva, Clara Ênia de Torres, Gabriella Parreiras Oliveira, Guilherme Corrêa de Gava, Sandra Grossi Falconi, Franco Harald Mourão, Marina Moraes |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paula, Naiara Cristina Clemente dos Santos Tavares de Moreira, Bernardo Pereira Armstrong, Tom Paiva, Clara Ênia de Torres, Gabriella Parreiras Oliveira, Guilherme Corrêa de Gava, Sandra Grossi Falconi, Franco Harald Mourão, Marina Moraes |
| dc.subject.other.none.fl_str_mv |
Proteínas SmFES Proteínas SmRAF Schistosoma mansoni MEDTROP-Parasito Anais Congresso |
| topic |
Proteínas SmFES Proteínas SmRAF Schistosoma mansoni MEDTROP-Parasito Anais Congresso SmRAF protein kinases SmFES protein kinases Schistosoma mansoni Congress Proteínas Quinases Esquistossomose mansoni Congresso |
| dc.subject.en.none.fl_str_mv |
SmRAF protein kinases SmFES protein kinases Schistosoma mansoni Congress |
| dc.subject.decs.none.fl_str_mv |
Proteínas Quinases Esquistossomose mansoni Congresso |
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55º Congresso da Sociedade Brasileira de Medicina Tropical ◦ XXVI Congresso da Sociedade Brasileira de Parasitologia CHAGASLEISH 2019. Trabalho aparesentado no MEDTROP-Parasito 2019, realizado em Belo Horizonte no período de 28 a 31 de julho de 2019. |
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2019 |
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2019 |
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2024-09-05T12:26:06Z |
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2024-09-05T12:26:06Z |
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PAULA, Naiara Cristina Clemente dos Santos Tavares de et al. SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction. In: MEDTROP: PARASITO: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 55., 2019; CONGRESSO DA SOCIEDADE BRASILEIRA DE PARASITOLOGIA CHAGASLEISH, 26., 2019. Belo Horizonte. Anais... Belo Horizonte: SBMT, 2019. p. 106-107. |
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https://arca.fiocruz.br/handle/icict/65767 |
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PAULA, Naiara Cristina Clemente dos Santos Tavares de et al. SmFES and SmRAF protein kinases: roles in Schistosoma mansoni development and reproduction. In: MEDTROP: PARASITO: CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 55., 2019; CONGRESSO DA SOCIEDADE BRASILEIRA DE PARASITOLOGIA CHAGASLEISH, 26., 2019. Belo Horizonte. Anais... Belo Horizonte: SBMT, 2019. p. 106-107. |
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