Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.

Bibliographic Details
Main Author: Pernaute-Lau, Leyre
Publication Date: 2025
Other Authors: Recker, Mario, Tékété, Mamadou, Sousa, Taís Nóbrega de, Traore, Aliou, Fofana, Bakary, Sanogo, Kassim, Morris, Ulrika, Inoue, Juliana, Ferreira, Pedro E., Diallo, Nouhoum, Burhenne, Jürgen, Sagara, Issaka, Dicko, Alassane, Veiga, Maria I., Haefeli, Walter, Björkman, Anders, Djimde, Abdoulaye A., Borrmann, Steffen, Gil, José Pedro
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 1038/s41467-025-57726-5
Download full: https://arca.fiocruz.br/handle/icict/70274
Summary: Department of Microbiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Biosystems & Integrative Sciences Institute. Faculty of Sciences. University of Lisbon. Lisbon, Portugal. / The Art of Discovery. Derio, Basque Country, Spain.
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spelling Pernaute-Lau, LeyreRecker, MarioTékété, MamadouSousa, Taís Nóbrega deTraore, AliouFofana, BakarySanogo, KassimMorris, UlrikaInoue, JulianaFerreira, Pedro E.Diallo, NouhoumBurhenne, JürgenSagara, IssakaDicko, AlassaneVeiga, Maria I.Haefeli, WalterBjörkman, AndersDjimde, Abdoulaye A.Borrmann, SteffenGil, José Pedro2025-05-07T18:53:12Z2025-05-07T18:53:12Z2025PERNAUTE-LAU, Leyre et al. Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa. Nature Communications, v. 16, n. 1, 2680, 2025.2041-1723https://arca.fiocruz.br/handle/icict/702741038/s41467-025-57726-5engNatureDecreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Microbiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Biosystems & Integrative Sciences Institute. Faculty of Sciences. University of Lisbon. Lisbon, Portugal. / The Art of Discovery. Derio, Basque Country, Spain.Centre for Ecology and Conservation. University of Exeter. Penryn, UK. / Institute for Tropical Medicine. University of Tübingen. Tübingen, Germany.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali. / Dept. of Clinical Pharmacology. University of Heidelberg. Heidelberg, Germany.Department ofMicrobiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Pesquisa em Biologia Molecular e Imunologia da Malária. Belo Horizonte, MG, Brasil.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Department ofMicrobiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden.Institute for Tropical Medicine. University of Tübingen. Tübingen, Germany. / German Center for Infection Research. Tübingen, Germany.Life and Health Sciences Research Institute. School of Medicine. University of Minho, Braga, Portugal. / ICVS/3B’s─PT Government Associate Laboratory. Braga, Portugal.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.German Center for Infection Research. Tübingen, Germany.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Life and Health Sciences Research Institute. School of Medicine. University of Minho, Braga, Portugal. / ICVS/3B’s─PT Government Associate Laboratory. Braga, Portugal.German Center for Infection Research. Tübingen, Germany.Department ofMicrobiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Department of Global Public Health. Karolinska Institutet. Stockholm, Sweden.Malaria Research and Training Center. Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, Bamako, Mali.Institute for Tropical Medicine. University of Tübingen. Tübingen, Germany. / German Center for Infection Research. Tübingen, Germany. / Centre de Recherches Médicales de Lambaréné. Lambaréné, Gabon.Department ofMicrobiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Clinical Tropical Medicine. Global Health and Tropical Medicine. Institute of Hygiene and Tropical Medicine. Nova University of Lisbon. Lisbon, Portugal.Dihydroartemisinin-piperaquine (DHA-PPQ) is being recommended in Africa for the management of uncomplicated Plasmodium falciparum malaria and for chemoprevention strategies, based on the ability of piperaquine to delay reinfections. Although therapeutic resistance to piperaquine has been linked to increased copy number in plasmepsin-coding parasite genes (pfpm), their effect on the duration of the post-treatment prophylactic period remains unclear. Here, we retrospectively analyzed data from a randomized clinical trial, Where patients received either DHA-PPQ or artesunate-amodiaquine for recurrent malaria episodes over two years. We observed an increase in the relative risk of re-infection among patients receiving DHA-PPQ compared to artesunate amodiaquine after the first malaria season. This was driven by shorter average times to reinfection and coincided with an increased frequency of infections comprising pfpm3 multi-copy parasites. The decline in post-treatment protection of DHA-PPQ upon repeated use in a high transmission setting raises concerns for its wider use for chemopreventive strategies in Africa.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/6165a169-c6cf-4ef0-8586-22e6e8214e01/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALDecreased dihydroartemisinin-piperaquine.pdfDecreased dihydroartemisinin-piperaquine.pdfapplication/pdf1047829https://arca.fiocruz.br/bitstreams/4c99c4cd-1297-49f2-9697-bf3c203afea7/download4950c7dda89fb5c19dd9461fdcaaa0a8MD52trueAnonymousREADTEXTDecreased dihydroartemisinin-piperaquine.pdf.txtDecreased dihydroartemisinin-piperaquine.pdf.txtExtracted texttext/plain42191https://arca.fiocruz.br/bitstreams/5a14d775-2511-43ca-a883-f4e96e36471d/download162661db643c2256ed3c9e81623e99c2MD55falseAnonymousREADTHUMBNAILDecreased dihydroartemisinin-piperaquine.pdf.jpgDecreased dihydroartemisinin-piperaquine.pdf.jpgGenerated Thumbnailimage/jpeg6871https://arca.fiocruz.br/bitstreams/9a8bac51-3f66-488c-9d86-3d832f9aff24/downloada69a8341adc2527c71ab4b627b7bc71bMD56falseAnonymousREADicict/702742025-07-30 01:26:46.55open.accessoai:arca.fiocruz.br:icict/70274https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:26:46Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
title Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
spellingShingle Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
Pernaute-Lau, Leyre
title_short Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
title_full Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
title_fullStr Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
title_full_unstemmed Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
title_sort Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa.
author Pernaute-Lau, Leyre
author_facet Pernaute-Lau, Leyre
Recker, Mario
Tékété, Mamadou
Sousa, Taís Nóbrega de
Traore, Aliou
Fofana, Bakary
Sanogo, Kassim
Morris, Ulrika
Inoue, Juliana
Ferreira, Pedro E.
Diallo, Nouhoum
Burhenne, Jürgen
Sagara, Issaka
Dicko, Alassane
Veiga, Maria I.
Haefeli, Walter
Björkman, Anders
Djimde, Abdoulaye A.
Borrmann, Steffen
Gil, José Pedro
author_role author
author2 Recker, Mario
Tékété, Mamadou
Sousa, Taís Nóbrega de
Traore, Aliou
Fofana, Bakary
Sanogo, Kassim
Morris, Ulrika
Inoue, Juliana
Ferreira, Pedro E.
Diallo, Nouhoum
Burhenne, Jürgen
Sagara, Issaka
Dicko, Alassane
Veiga, Maria I.
Haefeli, Walter
Björkman, Anders
Djimde, Abdoulaye A.
Borrmann, Steffen
Gil, José Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pernaute-Lau, Leyre
Recker, Mario
Tékété, Mamadou
Sousa, Taís Nóbrega de
Traore, Aliou
Fofana, Bakary
Sanogo, Kassim
Morris, Ulrika
Inoue, Juliana
Ferreira, Pedro E.
Diallo, Nouhoum
Burhenne, Jürgen
Sagara, Issaka
Dicko, Alassane
Veiga, Maria I.
Haefeli, Walter
Björkman, Anders
Djimde, Abdoulaye A.
Borrmann, Steffen
Gil, José Pedro
description Department of Microbiology and Tumour Cell Biology. Karolinska Institutet. Stckholm, Sweden. / Biosystems & Integrative Sciences Institute. Faculty of Sciences. University of Lisbon. Lisbon, Portugal. / The Art of Discovery. Derio, Basque Country, Spain.
publishDate 2025
dc.date.accessioned.fl_str_mv 2025-05-07T18:53:12Z
dc.date.available.fl_str_mv 2025-05-07T18:53:12Z
dc.date.issued.fl_str_mv 2025
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PERNAUTE-LAU, Leyre et al. Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa. Nature Communications, v. 16, n. 1, 2680, 2025.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/70274
dc.identifier.issn.none.fl_str_mv 2041-1723
dc.identifier.doi.none.fl_str_mv 1038/s41467-025-57726-5
identifier_str_mv PERNAUTE-LAU, Leyre et al. Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa. Nature Communications, v. 16, n. 1, 2680, 2025.
2041-1723
1038/s41467-025-57726-5
url https://arca.fiocruz.br/handle/icict/70274
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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