Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease

Bibliographic Details
Main Author: Macêdo, Carolina Thé
Publication Date: 2015
Other Authors: Larocca, Ticiana Ferreira, Rabelo, Márcia Noya, Correia, Luís Cláudio Lemos, Moreira, Moisés Imbassahy Guimarães, Caldas, Alessandra Carvalho, Torreão, Jorge Andion, Souza, Bruno Solano de Freitas, Santos, Ricardo Ribeiro dos, Soares, Milena Botelho Pereira
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: /dx.doi.org/10.1016/j.ijcha.2015.05.007
Download full: https://arca.fiocruz.br/handle/icict/14257
Summary: Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Macêdo, Carolina ThéLarocca, Ticiana FerreiraRabelo, Márcia NoyaCorreia, Luís Cláudio LemosMoreira, Moisés Imbassahy GuimarãesCaldas, Alessandra CarvalhoTorreão, Jorge AndionSouza, Bruno Solano de FreitasSantos, Ricardo Ribeiro dosSoares, Milena Botelho Pereira2016-05-12T12:51:06Z2016-05-12T12:51:06Z2015MACEDO, C. T. et al. Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease. IJC Heart & Vasculature, v. 8, p. 75–80, 2015.2352-9067https://arca.fiocruz.br/handle/icict/14257/dx.doi.org/10.1016/j.ijcha.2015.05.007engElsevierAssessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, BrasilHospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilBackground: One of the most challenging issues of chronic Chagas disease is to provide earlier detection of heart involvement. Two-dimensional speckle tracking (2-D ST) echocardiography, a new imagingmodalitywith useful applications in several cardiac diseases, has been validated for subjects with myocardial infarction against cardiac magnetic resonance (CMR). Here we hypothesize that the longitudinal global strain (LGS) has an incremental value to ejection fraction for predicting myocardial fibrosis in subjects with Chagas disease. Methods: This observational study comprised 58 subjectswith Chagas disease, confirmed by two positive serologic tests. All subjects underwent conventional Doppler echocardiogramplus speckle tracking strain, and cardiacmagnetic resonance. Results: The ROC curve analysis revealed that both LGS (area under the curve: 0.78, p=0.001) and ejection fraction (area under the curve: 0.82, p b 0.001)were significant predictors ofmyocardial fibrosis. Regarding the percentage of fibrosis, a high correlation was observed with both ejection fraction assessed by echocardiography (r =0.70, p b 0.001) and LGS (r = 0.64, p b 0.001). However, when adjusted through multiple linear regression, the LGS lost statistical significance as a predictor of myocardial fibrosis (p = 0.111). Conclusions: LGS has no incremental value to conventional ejection fractionmeasurement in the prediction ofmyocardial fibrosis in subjects with Chagas disease.Speckle trackingChagas diseaseLongitudinal global straininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/ea6356ea-36c7-45f4-8e2c-9e6b54363d00/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALMacedo CT Assessment....pdfMacedo CT Assessment....pdfapplication/pdf661652https://arca.fiocruz.br/bitstreams/7463e954-79b3-4577-919e-d08e8230570c/downloada14aaf455b6a4c89eef253f8b95079bcMD52trueAnonymousREADTEXTMacedo CT Assessment....pdf.txtMacedo CT Assessment....pdf.txtExtracted texttext/plain34879https://arca.fiocruz.br/bitstreams/05a7e1c5-0986-4bb4-a219-d93dc8248b35/downloade052837cfe624632f1f12754a131dab2MD57falseAnonymousREADTHUMBNAILMacedo CT Assessment....pdf.jpgMacedo CT Assessment....pdf.jpgGenerated Thumbnailimage/jpeg5895https://arca.fiocruz.br/bitstreams/f644e4fb-d0cb-4429-98eb-19f6f1dc65eb/download94317d7de13ebff5bcdb6e3191a6b634MD58falseAnonymousREADicict/142572025-07-29 18:55:50.264open.accessoai:arca.fiocruz.br:icict/14257https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T21:55:50Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
title Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
spellingShingle Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
Macêdo, Carolina Thé
Speckle tracking
Chagas disease
Longitudinal global strain
title_short Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
title_full Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
title_fullStr Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
title_full_unstemmed Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
title_sort Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease
author Macêdo, Carolina Thé
author_facet Macêdo, Carolina Thé
Larocca, Ticiana Ferreira
Rabelo, Márcia Noya
Correia, Luís Cláudio Lemos
Moreira, Moisés Imbassahy Guimarães
Caldas, Alessandra Carvalho
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author_role author
author2 Larocca, Ticiana Ferreira
Rabelo, Márcia Noya
Correia, Luís Cláudio Lemos
Moreira, Moisés Imbassahy Guimarães
Caldas, Alessandra Carvalho
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macêdo, Carolina Thé
Larocca, Ticiana Ferreira
Rabelo, Márcia Noya
Correia, Luís Cláudio Lemos
Moreira, Moisés Imbassahy Guimarães
Caldas, Alessandra Carvalho
Torreão, Jorge Andion
Souza, Bruno Solano de Freitas
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
dc.subject.en.none.fl_str_mv Speckle tracking
Chagas disease
Longitudinal global strain
topic Speckle tracking
Chagas disease
Longitudinal global strain
description Hospital São Rafael. Departamento de Cardiologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-12T12:51:06Z
dc.date.available.fl_str_mv 2016-05-12T12:51:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO, C. T. et al. Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease. IJC Heart & Vasculature, v. 8, p. 75–80, 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/14257
dc.identifier.issn.none.fl_str_mv 2352-9067
dc.identifier.doi.none.fl_str_mv /dx.doi.org/10.1016/j.ijcha.2015.05.007
identifier_str_mv MACEDO, C. T. et al. Assessment of speckle tracking strain predictive value for myocardial fibrosis in subjects with Chagas disease. IJC Heart & Vasculature, v. 8, p. 75–80, 2015.
2352-9067
/dx.doi.org/10.1016/j.ijcha.2015.05.007
url https://arca.fiocruz.br/handle/icict/14257
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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