Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review

Bibliographic Details
Main Author: Badaró, Roberto José da Silva
Publication Date: 2014
Other Authors: Gonçalves, Larissa Oliveira, Gois, Luana Leandro, Maia, Zuinara Pereira Gusmão, Benson, Constance, Grassi, Maria Fernanda Rios
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1177/2325957414555225
Download full: https://arca.fiocruz.br/handle/icict/8818
Summary: Universidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, Brasil
id CRUZ_850f1352dd84cda934cd3d61d3d80286
oai_identifier_str oai:arca.fiocruz.br:icict/8818
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Badaró, Roberto José da SilvaGonçalves, Larissa OliveiraGois, Luana LeandroMaia, Zuinara Pereira GusmãoBenson, ConstanceGrassi, Maria Fernanda Rios2014-11-12T19:24:15Z2014-11-12T19:24:15Z2014BADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014.2325-9574https://arca.fiocruz.br/handle/icict/881810.1177/2325957414555225engSage PublicationsLeishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Faculdade de Medicina. Salvador, BA, BRasilUniversidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, BrasilUniversity of California San Diego. Division of Infectious Diseases. La Jolla, CA, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Faculdade de Medicina. Salvador, BA, BRasilIntroduction: After the onset of highly active antiretroviral therapy (HAART), some HIV-infected patients present a severe inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory syndrome (IRIS). Few reports of tegumentary and visceral leishmaniasis have been described in association with IRIS. Methods: A systematic literature review of IRIS in association with leishmaniasis identified 34 reported cases. Results and Discussion: The majority of these occurred in males 4 months following the onset of HAART. The mean CD4 count before HAART was 94 + 77 cells/mm3, increasing to 5 times the initial value between the onset of HAART and IRIS presentation. Visceral leishmaniasis and post–kala-azar dermal leishmaniasis were the most commonly reported clinical manifestations, followed by tegumentary leishmaniasis and uveitis. Conclusions: Commonly found characteristics included cutaneous involvement, regardless of Leishmania species; appearance of lesions unrelated to time of probable Leishmania infection; rapid recovery of CD4 count following HAART; and rapid progression.HIV/AIDSImmune reconstitution inflammatory syndromeIRISLeishmaniasisCo-infection HIV/Leishmaniainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBadaro R Leishmaniasis....pdfBadaro R Leishmaniasis....pdfapplication/pdf158970https://arca.fiocruz.br/bitstreams/c09255e2-3c2b-42f1-8bb0-3d45c8166f9c/downloadf93eac0bff32d08bf553dbd76380001cMD52trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://arca.fiocruz.br/bitstreams/0cab3c83-30ad-4ca4-b217-4911a173c664/download7d48279ffeed55da8dfe2f8e81f3b81fMD53falseAnonymousREADTEXTBadaro R Leishmaniasis....pdf.txtBadaro R Leishmaniasis....pdf.txtExtracted texttext/plain41770https://arca.fiocruz.br/bitstreams/45dbaeb1-a13d-4435-9c0f-cf2452488474/download60fe8d68662a208eb3cfee15b30d66d5MD56falseAnonymousREADTHUMBNAILBadaro R Leishmaniasis....pdf.jpgBadaro R Leishmaniasis....pdf.jpgGenerated Thumbnailimage/jpeg5306https://arca.fiocruz.br/bitstreams/ccc057bd-52a2-4d4c-8681-7b687f28e978/download647df08f8a5e2730fb118a0eea3e4c91MD57falseAnonymousREADicict/88182025-07-29 20:57:28.611open.accessoai:arca.fiocruz.br:icict/8818https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T23:57:28Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
title Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
spellingShingle Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
Badaró, Roberto José da Silva
HIV/AIDS
Immune reconstitution inflammatory syndrome
IRIS
Leishmaniasis
Co-infection HIV/Leishmania
title_short Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
title_full Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
title_fullStr Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
title_full_unstemmed Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
title_sort Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review
author Badaró, Roberto José da Silva
author_facet Badaró, Roberto José da Silva
Gonçalves, Larissa Oliveira
Gois, Luana Leandro
Maia, Zuinara Pereira Gusmão
Benson, Constance
Grassi, Maria Fernanda Rios
author_role author
author2 Gonçalves, Larissa Oliveira
Gois, Luana Leandro
Maia, Zuinara Pereira Gusmão
Benson, Constance
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Badaró, Roberto José da Silva
Gonçalves, Larissa Oliveira
Gois, Luana Leandro
Maia, Zuinara Pereira Gusmão
Benson, Constance
Grassi, Maria Fernanda Rios
dc.subject.en.none.fl_str_mv HIV/AIDS
Immune reconstitution inflammatory syndrome
IRIS
Leishmaniasis
Co-infection HIV/Leishmania
topic HIV/AIDS
Immune reconstitution inflammatory syndrome
IRIS
Leishmaniasis
Co-infection HIV/Leishmania
description Universidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, Brasil
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-11-12T19:24:15Z
dc.date.available.fl_str_mv 2014-11-12T19:24:15Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/8818
dc.identifier.issn.none.fl_str_mv 2325-9574
dc.identifier.doi.none.fl_str_mv 10.1177/2325957414555225
identifier_str_mv BADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014.
2325-9574
10.1177/2325957414555225
url https://arca.fiocruz.br/handle/icict/8818
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/c09255e2-3c2b-42f1-8bb0-3d45c8166f9c/download
https://arca.fiocruz.br/bitstreams/0cab3c83-30ad-4ca4-b217-4911a173c664/download
https://arca.fiocruz.br/bitstreams/45dbaeb1-a13d-4435-9c0f-cf2452488474/download
https://arca.fiocruz.br/bitstreams/ccc057bd-52a2-4d4c-8681-7b687f28e978/download
bitstream.checksum.fl_str_mv f93eac0bff32d08bf553dbd76380001c
7d48279ffeed55da8dfe2f8e81f3b81f
60fe8d68662a208eb3cfee15b30d66d5
647df08f8a5e2730fb118a0eea3e4c91
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839716012051660800

Similar Items