Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease

Bibliographic Details
Main Author: Gonçalves, Marilda de Souza
Publication Date: 2001
Other Authors: Queiroz, I. L., Cardoso, Silvia Andrade, Zanette, Angela Maria Dias, Strapazoni, A. C., Adorno, Elisângela Vitória, Albuquerque, Alessandra B. Lima, Sant'Ana, A., Reis, Mitermayer Galvão dos, Barral, Aldina Maria Prado, Barral Netto, Manoel
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://arca.fiocruz.br/handle/icict/5526
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Gonçalves, Marilda de SouzaQueiroz, I. L.Cardoso, Silvia AndradeZanette, Angela Maria DiasStrapazoni, A. C.Adorno, Elisângela VitóriaAlbuquerque, Alessandra B. LimaSant'Ana, A.Reis, Mitermayer Galvão dosBarral, Aldina Maria PradoBarral Netto, Manoel2012-09-18T21:17:54Z2012-09-18T21:17:54Z2001GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001.0100-879Xhttps://arca.fiocruz.br/handle/icict/5526engInterleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Hemocentro da Bahia. Secretaria de Saúde do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSickle cell disease has a worldwide distribution and is a public health problem in Brazil. Although vaso-occlusive crisis (VOC) is one of the most important clinical features of the disease, there are still several steps of its pathogenesis which are unknown. The increase of the chemotactic factor interleukin 8 (IL-8) has been reported to be involved in sickle cell disease crisis, but this has not been demonstrated conclusively. In the present study we analyzed serum IL-8 levels by ELISA and hematological parameters and hemoglobin patterns by standard techniques in 23 (21 SS and 2 SC) Brazilian patients with sickle cell syndromes during VOC caused by different inducing factors, 22 (21 SS and 1 SC) sickle cell patients out of crisis, and 11 healthy controls. Increased IL-8 levels were observed in 19 of 23 VOC patients (79.2%), 3 of them with more than 1,000 pg/ml. Seventeen of 22 (77.3%) non-crisis patients showed low IL-8 levels (less than 15 pg/ml). Healthy controls had low IL-8 levels. A significant difference in serum IL-8 levels was observed between crisis and non-crisis sickle cell patients (P<0.0001). There was no correlation between IL-8 levels and hematological data or hemoglobin patterns. High serum IL-8 levels were observed in VOC patients independently of the crisis-inducing factor. We conclude that in the studied population, IL-8 concentration may be a useful VOC marker, although the mechanism of the pathogenic process of sickle cell VOC syndromes remains unclear.Interleukin 8Sickle cell syndromesVaso-occlusive crisisAnemia Falciforme/sangueArteriopatias Oclusivas/sangueInterleucina-8/sangueAnemia Falciforme/fisiopatologiaAdolescenteAdultoArteriopatias Oclusivas/etiologiaMarcadores Biológicos/sangueBrasilCriançaPré-EscolarFemininoHemoglobina Falciforme/análiseHemoglobinas/análiseHumanosLactenteMeia-IdadeFatores de RiscoSindromeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGoncalves MS Interleukin 8 as a vaso-occlusive....pdfGoncalves MS Interleukin 8 as a vaso-occlusive....pdfapplication/pdf152416https://arca.fiocruz.br/bitstreams/73124584-5cf8-4d9a-8b2a-3a0aefb8a661/download512aa64419dd6e1503998984ac84211dMD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://arca.fiocruz.br/bitstreams/5e9c86aa-8a72-43dc-9512-290a7a05a805/download06db3f0df647fd9ddff657403bbe0ee2MD52falseAnonymousREADTEXTGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.txtGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.txtExtracted texttext/plain21161https://arca.fiocruz.br/bitstreams/c5fbb8b5-45c4-4b74-81dd-f25befc71334/downloadbc457436f03e66a54002e7c2f235be66MD58falseAnonymousREADTHUMBNAILGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.jpgGoncalves MS Interleukin 8 as a vaso-occlusive....pdf.jpgGenerated Thumbnailimage/jpeg4982https://arca.fiocruz.br/bitstreams/b3e2b190-0b45-4aec-943c-63e75c20fc03/download796b6729664974dbf2ab2e0bc540142cMD59falseAnonymousREADicict/55262025-07-29 19:29:18.141open.accessoai:arca.fiocruz.br:icict/5526https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:29:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
spellingShingle Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
Gonçalves, Marilda de Souza
Interleukin 8
Sickle cell syndromes
Vaso-occlusive crisis
Anemia Falciforme/sangue
Arteriopatias Oclusivas/sangue
Interleucina-8/sangue
Anemia Falciforme/fisiopatologia
Adolescente
Adulto
Arteriopatias Oclusivas/etiologia
Marcadores Biológicos/sangue
Brasil
Criança
Pré-Escolar
Feminino
Hemoglobina Falciforme/análise
Hemoglobinas/análise
Humanos
Lactente
Meia-Idade
Fatores de Risco
Sindrome
title_short Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_full Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_fullStr Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_full_unstemmed Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
title_sort Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease
author Gonçalves, Marilda de Souza
author_facet Gonçalves, Marilda de Souza
Queiroz, I. L.
Cardoso, Silvia Andrade
Zanette, Angela Maria Dias
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Alessandra B. Lima
Sant'Ana, A.
Reis, Mitermayer Galvão dos
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Queiroz, I. L.
Cardoso, Silvia Andrade
Zanette, Angela Maria Dias
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Alessandra B. Lima
Sant'Ana, A.
Reis, Mitermayer Galvão dos
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Marilda de Souza
Queiroz, I. L.
Cardoso, Silvia Andrade
Zanette, Angela Maria Dias
Strapazoni, A. C.
Adorno, Elisângela Vitória
Albuquerque, Alessandra B. Lima
Sant'Ana, A.
Reis, Mitermayer Galvão dos
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.en.none.fl_str_mv Interleukin 8
Sickle cell syndromes
Vaso-occlusive crisis
topic Interleukin 8
Sickle cell syndromes
Vaso-occlusive crisis
Anemia Falciforme/sangue
Arteriopatias Oclusivas/sangue
Interleucina-8/sangue
Anemia Falciforme/fisiopatologia
Adolescente
Adulto
Arteriopatias Oclusivas/etiologia
Marcadores Biológicos/sangue
Brasil
Criança
Pré-Escolar
Feminino
Hemoglobina Falciforme/análise
Hemoglobinas/análise
Humanos
Lactente
Meia-Idade
Fatores de Risco
Sindrome
dc.subject.decs.none.fl_str_mv Anemia Falciforme/sangue
Arteriopatias Oclusivas/sangue
Interleucina-8/sangue
Anemia Falciforme/fisiopatologia
Adolescente
Adulto
Arteriopatias Oclusivas/etiologia
Marcadores Biológicos/sangue
Brasil
Criança
Pré-Escolar
Feminino
Hemoglobina Falciforme/análise
Hemoglobinas/análise
Humanos
Lactente
Meia-Idade
Fatores de Risco
Sindrome
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-09-18T21:17:54Z
dc.date.available.fl_str_mv 2012-09-18T21:17:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/5526
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv GONÇALVES, M.S. et al. Interleukin 8 as a vaso-occlusive marker in Brazilian patients with sickle cell disease. Brazilian Journal of Medical and Biological Research, v. 34, n. 10, p. 1309-13, oct. 2001.
0100-879X
url https://arca.fiocruz.br/handle/icict/5526
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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