Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers.
| Main Author: | |
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| Publication Date: | 1999 |
| Other Authors: | , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://arca.fiocruz.br/handle/icict/7899 |
Summary: | Universidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, Brasil |
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Cotrim, Helma PinchemelAndrade, Zilton de AraújoParaná, RaymundoPortugal, MarceloLyra, Luiz Guilherme CostaFreitas, Luiz Antonio Rodrigues de2014-07-10T12:14:17Z2014-07-10T12:14:17Z1999COTRIM, H.P. et al. Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Liver, v. 19, n. 4, p. 299-304, 1999.0106-9543https://arca.fiocruz.br/handle/icict/7899engBlackwell MunksgaardNonalcoholic steatohepatitis: a toxic liver disease in industrial workers.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, BrasilUniversidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, BrasilUniversidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilAIMS: Occupational/environmental exposure to hepatotoxins has recently been implicated in nonalcoholic steatohepatitis (NASH). The aims of this study were to determine the presence and frequency of NASH in a large group of workers chronically exposed to several volatile petrochemical products in an industrial area in north-east Brazil and to observe its course in workers removed from the work environment. METHODS: 1500 asymptomatic workers were screened with standard liver blood tests during 1994-5. Those with elevated transaminases (>3x normal) on 3 occasions were evaluated further both clinically and with serum HBsAg, anti-HCV, ferritin, lipids and autoantibody determination. Patients with either no etiological diagnosis, positive HBsAg/anti-HCV serology and/or excess alcohol intake underwent liver biopsy. Those with obesity, diabetes or an isolated abnormal GGT were excluded. Of workers diagnosed as having NASH (compatible histology and no excess alcohol intake), a proportion were removed from the work environment and evaluated monthly with liver blood tests and a repeat liver biopsy 8-14 months later. RESULTS: 112 workers had abnormal transaminases and 32 fulfilled the criteria for liver biopsy. 20 of these were classified as NASH, the remainder had viral hepatitis (n = 6), alcoholic liver disease (n = 5) or portal vein thrombosis (n = 1). In all of the 10/20 who were removed from the work environment, their aminotransferases and GGT gradually decreased and their histology improved. CONCLUSIONS: These results demonstrate that NASH can occur following chronic exposure to volatile petrochemical substances in the workplace. Exposed workers should be regularly screened for the presence of liver damage and ideally removed from the work environment where possible.Nonalcoholic steatohepatitisHepatotoxicityToxic liver injuryEnvironmental hepatotoxinsDoença Hepática Induzida por Drogas/etiologiaFígado Gorduroso/induzido quimicamenteFígado/efeitos de drogasDoenças Profissionais/induzido quimicamenteExposição Ocupacional/efeitos adversosPetróleo/efeitos adversosAdultoBiópsiaBrasilDiagnóstico DiferencialDoença Hepática Induzida por Drogas/enzimologiaFígado Gorduroso/enzimologiaFemininoSeguimentosFígado/ultraestruturaHumanosDoenças Profissionais/enzimologiaMeia-IdadeEstudos ProspectivosTransaminases/sangueinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCotrim HP Nonalcoholic....pdfCotrim HP Nonalcoholic....pdfapplication/pdf1488046https://arca.fiocruz.br/bitstreams/7df22c67-b151-4cdb-a2b4-7c479f0ce5e3/download6c5b0780faf90818537f46c953dd8794MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://arca.fiocruz.br/bitstreams/59a5cd2f-7bb6-4fd1-a8d0-d1394e297f91/download7d48279ffeed55da8dfe2f8e81f3b81fMD52falseAnonymousREADTEXTCotrim HP Nonalcoholic....pdf.txtCotrim HP Nonalcoholic....pdf.txtExtracted texttext/plain18926https://arca.fiocruz.br/bitstreams/c3cf2441-757a-4198-93c7-02e8a33c4a87/download93133e50e56428ba6f1caad57bbec3b1MD55falseAnonymousREADTHUMBNAILCotrim HP Nonalcoholic....pdf.jpgCotrim HP Nonalcoholic....pdf.jpgGenerated Thumbnailimage/jpeg6295https://arca.fiocruz.br/bitstreams/fc80362e-6532-45b0-8e93-6fc8ca2ab39c/downloadeaf0bb913e98ac0f28d39b8fe44b271dMD56falseAnonymousREADicict/78992025-07-29 21:32:40.283open.accessoai:arca.fiocruz.br:icict/7899https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T00:32:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)falseTElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4K |
| dc.title.none.fl_str_mv |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| title |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| spellingShingle |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Cotrim, Helma Pinchemel Nonalcoholic steatohepatitis Hepatotoxicity Toxic liver injury Environmental hepatotoxins Doença Hepática Induzida por Drogas/etiologia Fígado Gorduroso/induzido quimicamente Fígado/efeitos de drogas Doenças Profissionais/induzido quimicamente Exposição Ocupacional/efeitos adversos Petróleo/efeitos adversos Adulto Biópsia Brasil Diagnóstico Diferencial Doença Hepática Induzida por Drogas/enzimologia Fígado Gorduroso/enzimologia Feminino Seguimentos Fígado/ultraestrutura Humanos Doenças Profissionais/enzimologia Meia-Idade Estudos Prospectivos Transaminases/sangue |
| title_short |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| title_full |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| title_fullStr |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| title_full_unstemmed |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| title_sort |
Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. |
| author |
Cotrim, Helma Pinchemel |
| author_facet |
Cotrim, Helma Pinchemel Andrade, Zilton de Araújo Paraná, Raymundo Portugal, Marcelo Lyra, Luiz Guilherme Costa Freitas, Luiz Antonio Rodrigues de |
| author_role |
author |
| author2 |
Andrade, Zilton de Araújo Paraná, Raymundo Portugal, Marcelo Lyra, Luiz Guilherme Costa Freitas, Luiz Antonio Rodrigues de |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Cotrim, Helma Pinchemel Andrade, Zilton de Araújo Paraná, Raymundo Portugal, Marcelo Lyra, Luiz Guilherme Costa Freitas, Luiz Antonio Rodrigues de |
| dc.subject.en.none.fl_str_mv |
Nonalcoholic steatohepatitis Hepatotoxicity Toxic liver injury Environmental hepatotoxins |
| topic |
Nonalcoholic steatohepatitis Hepatotoxicity Toxic liver injury Environmental hepatotoxins Doença Hepática Induzida por Drogas/etiologia Fígado Gorduroso/induzido quimicamente Fígado/efeitos de drogas Doenças Profissionais/induzido quimicamente Exposição Ocupacional/efeitos adversos Petróleo/efeitos adversos Adulto Biópsia Brasil Diagnóstico Diferencial Doença Hepática Induzida por Drogas/enzimologia Fígado Gorduroso/enzimologia Feminino Seguimentos Fígado/ultraestrutura Humanos Doenças Profissionais/enzimologia Meia-Idade Estudos Prospectivos Transaminases/sangue |
| dc.subject.decs.none.fl_str_mv |
Doença Hepática Induzida por Drogas/etiologia Fígado Gorduroso/induzido quimicamente Fígado/efeitos de drogas Doenças Profissionais/induzido quimicamente Exposição Ocupacional/efeitos adversos Petróleo/efeitos adversos Adulto Biópsia Brasil Diagnóstico Diferencial Doença Hepática Induzida por Drogas/enzimologia Fígado Gorduroso/enzimologia Feminino Seguimentos Fígado/ultraestrutura Humanos Doenças Profissionais/enzimologia Meia-Idade Estudos Prospectivos Transaminases/sangue |
| description |
Universidade Federal da Bahia. Division the Gastroenterology. Salvador, BA, Brasil |
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1999 |
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1999 |
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2014-07-10T12:14:17Z |
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2014-07-10T12:14:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
COTRIM, H.P. et al. Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Liver, v. 19, n. 4, p. 299-304, 1999. |
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https://arca.fiocruz.br/handle/icict/7899 |
| dc.identifier.issn.none.fl_str_mv |
0106-9543 |
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COTRIM, H.P. et al. Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Liver, v. 19, n. 4, p. 299-304, 1999. 0106-9543 |
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Blackwell Munksgaard |
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Blackwell Munksgaard |
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