Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes

Bibliographic Details
Main Author: Silva, Fernanda Fonseca
Publication Date: 2013
Other Authors: Inacio, Job D. F., Cavalheiro, Marilene M. Canto, Amaral, Elmo E. Almeida
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1021/np400193m
Download full: https://arca.fiocruz.br/handle/icict/27111
Summary: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.
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spelling Silva, Fernanda FonsecaInacio, Job D. F.Cavalheiro, Marilene M. CantoAmaral, Elmo E. Almeida2018-06-26T14:09:27Z2018-06-26T14:09:27Z2013SILVA, Fernanda Fonseca; et al. Reactive Oxygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes. J. Nat. Prod. v.76, p.1505−1508, July 2013.0163-3864https://arca.fiocruz.br/handle/icict/2711110.1021/np400193m1520-6025engAmerican Chemical SocietyLeishmania amazonensisQuercetinaatividade antileishmanialTratamentoantileishmanial activityquercetinLeishmania amazonensisTreatmentReactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.The present study reports the mechanism of the antileishmanial activity of quercetin against the intracellular amastigote form of Leishmania amazonensis. Treatment with 1 reduced the infection index in L. amazonensis-infected macrophages in a dose-dependent manner, with an IC₅₀ value of 3.4 μM and a selectivity index of 16.8, and additionally increased ROS generation also in a dose-dependent manner. Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death. Taken together, these results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/9e1fbe9c-fb78-4b4e-898a-9f9584eceee3/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALjobD_inacio_etal_IOC_2013.pdfjobD_inacio_etal_IOC_2013.pdfapplication/pdf238824https://arca.fiocruz.br/bitstreams/f7cb28b5-61de-4012-b36e-5e699cb03601/download39f61d8a84e7b02c095b411433569c4aMD52trueAnonymousREADTEXTjobD_inacio_etal_IOC_2013.pdf.txtjobD_inacio_etal_IOC_2013.pdf.txtExtracted texttext/plain17479https://arca.fiocruz.br/bitstreams/78268b1a-6683-4395-b97f-10bbf265ea01/download61daf470a18846e9301213cb3bd96652MD55falseAnonymousREADTHUMBNAILjobD_inacio_etal_IOC_2013.pdf.jpgjobD_inacio_etal_IOC_2013.pdf.jpgGenerated Thumbnailimage/jpeg6466https://arca.fiocruz.br/bitstreams/ed49ae03-50c7-4115-847a-abec2d91ec71/downloade1726ba5106f0b5cf8c3f6f7878614f7MD56falseAnonymousREADicict/271112025-07-29 22:37:51.98open.accessoai:arca.fiocruz.br:icict/27111https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T01:37:51Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
title Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
spellingShingle Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
Silva, Fernanda Fonseca
Leishmania amazonensis
Quercetina
atividade antileishmanial
Tratamento
antileishmanial activity
quercetin
Leishmania amazonensis
Treatment
title_short Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
title_full Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
title_fullStr Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
title_full_unstemmed Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
title_sort Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes
author Silva, Fernanda Fonseca
author_facet Silva, Fernanda Fonseca
Inacio, Job D. F.
Cavalheiro, Marilene M. Canto
Amaral, Elmo E. Almeida
author_role author
author2 Inacio, Job D. F.
Cavalheiro, Marilene M. Canto
Amaral, Elmo E. Almeida
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Fernanda Fonseca
Inacio, Job D. F.
Cavalheiro, Marilene M. Canto
Amaral, Elmo E. Almeida
dc.subject.other.none.fl_str_mv Leishmania amazonensis
Quercetina
atividade antileishmanial
Tratamento
topic Leishmania amazonensis
Quercetina
atividade antileishmanial
Tratamento
antileishmanial activity
quercetin
Leishmania amazonensis
Treatment
dc.subject.en.none.fl_str_mv antileishmanial activity
quercetin
Leishmania amazonensis
Treatment
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ. Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-06-26T14:09:27Z
dc.date.available.fl_str_mv 2018-06-26T14:09:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Fernanda Fonseca; et al. Reactive Oxygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes. J. Nat. Prod. v.76, p.1505−1508, July 2013.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/27111
dc.identifier.issn.none.fl_str_mv 0163-3864
dc.identifier.doi.none.fl_str_mv 10.1021/np400193m
dc.identifier.eissn.none.fl_str_mv 1520-6025
identifier_str_mv SILVA, Fernanda Fonseca; et al. Reactive Oxygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes. J. Nat. Prod. v.76, p.1505−1508, July 2013.
0163-3864
10.1021/np400193m
1520-6025
url https://arca.fiocruz.br/handle/icict/27111
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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