miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis

Detalhes bibliográficos
Autor(a) principal: Noronha, M. A. P. L. de
Data de Publicação: 2023
Outros Autores: Marinho, A. I., Araújo, S. N. D. O., Tavares, N. M.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://arca.fiocruz.br/handle/icict/64812
Resumo: Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Noronha, M. A. P. L. deMarinho, A. I.Araújo, S. N. D. O.Tavares, N. M.2024-07-03T14:33:42Z2024-07-03T14:33:42Z2023NORONHA, M. A. P. L. de et al. miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 46, 2023, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: SBI, 02 a 6 de outubro de 2023. p.1-33.https://arca.fiocruz.br/handle/icict/64812engSociedade Brasileira de ImunologiaLeshimaniosemiRNABiomarcadorLeshimaniosismiRNABiomarkerLeishmanioseMicroRNAsBiomarcadoresmiR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectUniversidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasita-Hospedeiro e Epidemiologia (LAIPHE). Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasita-Hospedeiro e Epidemiologia (LAIPHE). Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasita-Hospedeiro e Epidemiologia (LAIPHE). Salvador, BA, Brasil.Background: Leishmaniasis are neglected tropical diseases caused by Leishmania, an important public health problem affecting 12 millon people worldwise. Cutaneous leishmaniasis (CL) is the most frequent form of this disease. It was demonstrated from gene expression analysis that miR-193b, miR-671 and TREM-1 in CL lesions correlate in patients with early cure (within 60 days), indicating that these molecules have potential use as prognostic bioindicators. Methods: The study is approved by the Research Ethics Committee. Samples (biopsy and blood) of 21 patients were collected in Corte de Pedra – Bahia. The blood was processed to obtain peripheral blood mononuclear cells. Total RNA was extracted, cDNA was obtained and gene expression was evaluated by RT-qPCR. Results: In these samples, it was possible to profile the expression of miR-193b and TREM-1 in comparison with healthy controls from a non-endemic area. miR193b expression was significantly reduced in patient biopsies compared to controls. Besides, TREM1 expression was significantly increased in biopsies when compared to the healthy control. But, when comparing patients who heal within 59 days of treatment with those who heal after 60 days, there was no statistical difference in the expression profile of miR- 193b and TREM-1. Conclusion: Due to the complexity of the interaction between the host and the pathogen, the immune response can evoke different solutions for the establishment, survival and persistence of the parasite. Studying this diversity is important to define molecules that may indicate the early prognosis of a chronic disease, such as CL. The data reinforce the potential of miRNA and TREM-1 as possible biomarkers of CL patients with shorter healing time. Based on the results obtained, it will be possible to understand the potential of miR-193b, miR-671 and TREM-1 as promising candidates for application in clinical practice in patients with CL caused by L. braziliensis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/aea8b144-a7be-44b8-8eb6-b4b7513f39ce/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALDe Noronha, M.A.P.L - miR-193b, miR-671 and TREM-1.pdfDe Noronha, M.A.P.L - miR-193b, miR-671 and TREM-1.pdfapplication/pdf1217028https://arca.fiocruz.br/bitstreams/f6b6627e-63de-40f1-af50-22f2c99364db/downloadb628a525769775cfea058088c6db3828MD52trueAnonymousREADTEXTDe Noronha, M.A.P.L - miR-193b, miR-671 and TREM-1.pdf.txtDe Noronha, M.A.P.L - miR-193b, miR-671 and TREM-1.pdf.txtExtracted texttext/plain40636https://arca.fiocruz.br/bitstreams/31c04136-d900-4b93-84c3-b7ad66f79c92/download299d42a363a1754305df9d6a0f1e68a9MD55falseAnonymousREADTHUMBNAILDe Noronha, M.A.P.L - 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dc.title.none.fl_str_mv miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
title miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
spellingShingle miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
Noronha, M. A. P. L. de
Leshimaniose
miRNA
Biomarcador
Leshimaniosis
miRNA
Biomarker
Leishmaniose
MicroRNAs
Biomarcadores
title_short miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
title_full miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
title_fullStr miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
title_full_unstemmed miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
title_sort miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis
author Noronha, M. A. P. L. de
author_facet Noronha, M. A. P. L. de
Marinho, A. I.
Araújo, S. N. D. O.
Tavares, N. M.
author_role author
author2 Marinho, A. I.
Araújo, S. N. D. O.
Tavares, N. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Noronha, M. A. P. L. de
Marinho, A. I.
Araújo, S. N. D. O.
Tavares, N. M.
dc.subject.other.none.fl_str_mv Leshimaniose
miRNA
Biomarcador
topic Leshimaniose
miRNA
Biomarcador
Leshimaniosis
miRNA
Biomarker
Leishmaniose
MicroRNAs
Biomarcadores
dc.subject.en.none.fl_str_mv Leshimaniosis
miRNA
Biomarker
dc.subject.decs.none.fl_str_mv Leishmaniose
MicroRNAs
Biomarcadores
description Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2023
dc.date.issued.fl_str_mv 2023
dc.date.accessioned.fl_str_mv 2024-07-03T14:33:42Z
dc.date.available.fl_str_mv 2024-07-03T14:33:42Z
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dc.identifier.citation.fl_str_mv NORONHA, M. A. P. L. de et al. miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 46, 2023, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: SBI, 02 a 6 de outubro de 2023. p.1-33.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/64812
identifier_str_mv NORONHA, M. A. P. L. de et al. miR-193b, miR-671 and TREM-1 as molecular prognostic biomarkers in leishmaniasis caused by L. braziliensis. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 46, 2023, Ouro Preto, MG. Anais eletrônicos [...] Ouro Preto, MG: SBI, 02 a 6 de outubro de 2023. p.1-33.
url https://arca.fiocruz.br/handle/icict/64812
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Imunologia
publisher.none.fl_str_mv Sociedade Brasileira de Imunologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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