Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues

• Main Author: Nabavi,Seyed M.
• Publication Date: 2012
• Other Authors: Nabavi,Seyed F., Moghaddam,Akbar H., Setzer,William N., Mirzaei,Morteza
• Format: Article
• Language: eng
• Source: Anais da Academia Brasileira de Ciências (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
• topic: catalase; glutathione; sodium fluoride; superoxide dismutase; silymarin; TBARS

This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.