Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil

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Bibliographische Detailangaben
1. Verfasser:	Cruz, Márcio R
Publikationsdatum:	2004
Weitere Verfasser:	Cerqueira, Daniela M, Cruz, Waldenor B, Camara, Geni NL, Brígido, Marcelo de Macedo, Silva, Evandro O, Carvalho, Luciano GS, Martins, Cláudia RF
Format:	Article
Sprache:	eng
Quelle:	Repositório Institucional da UnB
Download full:	http://repositorio.unb.br/handle/10482/26144 https://dx.doi.org/10.1590/S0074-02762004000300007
Zusammenfassung:	We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.

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